Neuroimaging Acupuncture effects on human Brain Activity

神经影像学针灸对人类大脑活动的影响

• 批准号: 6749833
• 负责人: KATHLEEN K. S. HUI
• 金额: $ 118.41万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-15 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6749833
• 关键词: acupuncture /acupressure; alternative medicine; bioimaging /biomedical imaging; brain electrical activity; brain stem; catechol methyltransferase; central nervous system; cerebellum; functional magnetic resonance imaging; galvanic skin response; genotype; heart rate; hemodynamics; human subject; limbic system; neuroimaging; neuroregulation; neurotransmitters; pain; parietal lobe /cortex; prefrontal lobe /cortex; psychophysics; touch

Acupuncture is an ancient (over 2500 years old) therapeutic practice that originated in China and is growing in popularity in the West. However, scientific research into its underlying basic mechanisms is relatively recent and incomplete. The purpose of the proposed Project is to determine how acupuncture, with its variable treatment locations and stimulation techniques, affects human brain activity. We will accomplish this by integrating whole brain functional MRI (fMRI) with psychophysical, physiological, and genotyping investigations. Many classical acupuncture points are proposed to have multiple regulatory functions and diverse clinical effects. If a common neural substrate subserves these multiple functions, it would require neural circuits that could modulate multiple physiological and neural systems. Given the rich diffusely projecting innervations of the monoamine neurotransmitter system, these neuromodulators, especially dopamine, may play an important early role in acupuncture action. Our overall hypothesis is that acupuncture will elicit a widespread brain response that is predominantly modulatory. The limbic system in particular, with its rich dopaminergic innervation, will play a central role. We will also explore the central neural substrate of deqi, a unique acupuncture sensation that is considered essential to clinical efficacy in traditional Chinese acupuncture. This Project will work with the other Project teams and the Neuroanatomy and Biostatistics Core to understand the neurobiology of acupuncture action and promote the development of this ancient healing technique into evidence-based medicine.

针灸是一种古老的（超过2500岁）治疗实践，起源于中国，并在西方越来越受欢迎。然而，对其基本机制的科学研究相对较新，也不完整。该项目的目的是确定针灸如何通过其可变的治疗位置和刺激技术影响人类大脑活动。我们将通过整合全脑功能磁共振成像（fMRI）与心理物理，生理和基因分型研究来实现这一目标。许多经典穴位被提出具有多种调节功能和不同的临床效果。如果一个共同的神经基质支持这些多功能，它将需要 可以调节多种生理和神经系统的神经回路。由于单胺类神经递质系统具有丰富的弥散性投射神经支配，这些神经调质，尤其是多巴胺，可能在针刺作用的早期发挥重要作用。我们的总体假设是，针灸将引起广泛的大脑反应，主要是调节。特别是边缘系统，其丰富的多巴胺能神经支配，将发挥核心作用。我们还将探讨得气的中枢神经基质，这是一种独特的针灸感觉，被认为是中国传统针灸临床疗效的关键。该项目将与其他项目团队和神经解剖学合作 和生物统计学核心了解针灸作用的神经生物学，并促进这种古老的治疗技术发展为循证医学。