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STAFF PRIORITY TIME CRYSTAL STRUCTURE DETERMINATION OF PNGASE F

STAFF PRIORITY TIME CRYSTAL STRUCTURE DETERMINATION OF PNGASE F
工作人员优先确定 PNGASE F 的时间晶体结构
批准号：
6586498
负责人：
PETER KUHN
金额：
$14.32万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
项目状态：
已结题
起止时间：
2002-03-01 至 2003-02-28
来源：
https://reporter.nih.gov/project-details/6586498
关键词：
bioimaging /biomedical imaging biomaterials biomedical resource carbohydrates proteins radiography structural biology

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英文摘要
Peptide-N4-(N-acetyl-b-D-glucosaminyl) asparagine amidase F is a 34kDa aminohydrolase from Flavobacterium meningosepticum that removes intact asparagine-linked oligosaccharides from glycoproteins. High resolution crystallographic data (1.6 E and better) were collected on three mutants and the native enzyme in complex with the product, di-N-acetylchitobiose. The model is currently being refined against the data sets. The R-factors of all models are around 18%. The high resolution structures show clear details of binding of the enzyme to its product and provide new starting points for the design of further experiments aimed at the investigation of the mechanism of the enzyme.
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