CRYSTAL STRUCTURE OF HUMAN FIBRINOGEN FRAGMENT D

人纤维蛋白原片段 D 的晶体结构

• 批准号: 6586653
• 负责人: RUSSELL F DOOLITTLE
• 金额: $ 14.32万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-03-01 至 2003-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6586653
• 关键词: bioimaging /biomedical imaging; biomaterials; biomedical resource; hematology; proteins; radiography; structural biology

Fibrinogen is the precursor of fibrin, the material of which blood clots are composed. It is a large molecular weight complicated protein composed of two pairs of three non-identical polypeptide chains. A genuine X-ray structure has never been obtained. Now we are determining the structures of the principal fragments of human fibrinogen, the largest of which is called fragment D. We have collected data on crystals of this fragment out to 3.8 E on an area detector, and data from several isomorphous derivatives have provided a preliminary if somewhat ambiguous electron density map. We hope that synchrotron data would allow better resolution.

纤维蛋白原是纤维蛋白的前体， 凝块组成。 它是一种大分子量的复杂 由两对三个不同多肽组成的蛋白质 店 真正的X射线结构从未被获得。 现在我们 正在确定人类基因组的主要片段的结构 纤维蛋白原，其中最大的称为片段D。我们有 收集了这个碎片在3.8E区域的晶体数据 检测器，并从几个同晶衍生物的数据提供了 初步的电子密度图，虽然有些模糊。 我们希望 同步加速器的数据能提供更好的分辨率