CRYSTAL STRUCTURE OF VON WILLEBRAND FACTOR AL DOMAIN
CRYSTAL STRUCTURE OF VON WILLEBRAND FACTOR AL DOMAIN
批准号:
6658582
负责人:
KOTTAYIL I VARUGHESE
金额:
$14.32万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2002
资助国家:
美国
项目状态:
已结题
起止时间:
2002-03-01 至 2003-02-28
中文摘要
我们希望利用同步辐射技术来确定
人血管性血友病因子(vWF)A1结构域的3D结构。
从该项目中获得的信息将有助于澄清
关键事件的机制和调控
止血,还参与病理性血栓形成。
目前认为天然vWF的结晶是不可能的,
由于大尺寸和异质性,
分子;因此这是获取3D信息的唯一方法
vWF的结构是集中在孤立的结构域。 结果
我们的研究预期将有助于定义vWF-GP Ib接触
研究中心,并将协助寻找vWF的特异性抑制剂
与抗血栓的重要靶点GP Ib结合
干预
英文摘要
We wish to use synchrotron radiation techniques to determine the
3D structure of the A1 domain of human von Willebrand factor (vWF).
The information gained from this project will help clarify the
mechanisms and regulation of a key event essential for normal
hemostasis and also involved in pathological thrombosis.
Crystallization of native vWF is considered impossible with currently
available techniques due to the large size and heterogeneous nature of
the molecule; thus the only approach to gain information on the 3D
structure of vWF is to focus on isolated domains. The results
expected from our studies will help in defining the vWF-GP Ib contact
sites and will assist in searching for specific inhibitors of vWF
binding to GP Ib, an important target for anti-thrombotic
intervention.
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会议论文
1) ADHESIVE MOLECULAR INTERACTIONS IN PLATELET FUNCTION; 2) BACTERIAL SIGNALING
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批准号:8170088
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项目类别:
-
资助金额:$0.13万
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财政年份:2010
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负责人:KOTTAYIL I VARUGHESE
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依托单位:
1) ADHESIVE MOLECULAR INTERACTIONS IN PLATELET FUNCTION; 2) BACTERIAL SIGNALING
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批准号:7954415
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项目类别:
-
资助金额:$0.46万
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财政年份:2009
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负责人:KOTTAYIL I VARUGHESE
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依托单位:
A1 DOMAIN OF VON WILLEBRAND FACTOR COMPLEXES; AND BACTERIAL SIGNAL TRANSDUCTION
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批准号:7721736
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项目类别:
-
资助金额:$0.06万
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财政年份:2008
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负责人:KOTTAYIL I VARUGHESE
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依托单位:
1) ADHESIVE MOLECULAR INTERACTIONS IN PLATELET FUNCTION; 2) BACTERIAL SIGNALING
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批准号:7722106
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项目类别:
-
资助金额:$0.17万
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财政年份:2008
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负责人:KOTTAYIL I VARUGHESE
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依托单位:
K I VARUGHESE PRT TIME
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批准号:7597932
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项目类别:
-
资助金额:$0.02万
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财政年份:2007
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负责人:KOTTAYIL I VARUGHESE
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依托单位:
A1 DOMAIN OF VON WILLEBRAND FACTOR COMPLEXES; AND BACTERIAL SIGNAL TRANSDUCTION
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批准号:7597917
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项目类别:
-
资助金额:$0.14万
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财政年份:2007
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负责人:KOTTAYIL I VARUGHESE
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依托单位:
A1 DOMAIN OF VON WILLEBRAND FACTOR COMPLEXES; AND BACTERIAL SIGNAL TRANSDUCTION
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批准号:7370371
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项目类别:
-
资助金额:$0.09万
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财政年份:2006
-
负责人:KOTTAYIL I VARUGHESE
-
依托单位:
K I VARUGHESE PRT TIME
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批准号:7370396
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项目类别:
-
资助金额:$0.19万
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财政年份:2006
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负责人:KOTTAYIL I VARUGHESE
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依托单位:
STRUCTURE OF SPORULATION PROTEINS IN BACILLUS SUBTILIS
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批准号:7182496
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项目类别:
-
资助金额:$0.24万
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财政年份:2005
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负责人:KOTTAYIL I VARUGHESE
-
依托单位:
K I VARUGHESE PRT TIME
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批准号:7180389
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项目类别:
-
资助金额:$0.14万
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财政年份:2005
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负责人:KOTTAYIL I VARUGHESE
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依托单位:
VON WILLEBRAND FACTOR, PLATELET FUNCTION, NMC-4, GLYCOPROTEIN LBA, BOTROCETIN
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批准号:6976284
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项目类别:
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资助金额:$0.04万
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财政年份:2004
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负责人:KOTTAYIL I VARUGHESE
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依托单位:
A1 DOMAIN OF VON WILLEBRAND FACTOR & BACTERIAL SIGNAL TRANSDUCTION PROTEINS
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批准号:6976261
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项目类别:
-
资助金额:$0.11万
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财政年份:2004
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负责人:KOTTAYIL I VARUGHESE
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依托单位:
REGULATORY SUBUNIT OF CAMP DEPENDENT PROTEIN
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批准号:6658536
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项目类别:
-
资助金额:$14.32万
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财政年份:2002
-
负责人:KOTTAYIL I VARUGHESE
-
依托单位:
CRYSTAL STRUCTURE OF VON WILLEBRAND FACTOR AL DOMAIN
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批准号:6586615
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项目类别:
-
资助金额:$14.32万
-
财政年份:2002
-
负责人:KOTTAYIL I VARUGHESE
-
依托单位:
REGULATORY SUBUNIT OF CAMP DEPENDENT PROTEIN
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批准号:6586569
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项目类别:
-
资助金额:$14.32万
-
财政年份:2002
-
负责人:KOTTAYIL I VARUGHESE
-
依托单位:
CRYSTAL STRUCTURE OF VON WILLEBRAND FACTOR AL DOMAIN
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批准号:6437533
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项目类别:
-
资助金额:$14.32万
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财政年份:2001
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负责人:KOTTAYIL I VARUGHESE
-
依托单位:
REGULATORY SUBUNIT OF CAMP DEPENDENT PROTEIN
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批准号:6437487
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项目类别:
-
资助金额:$14.32万
-
财政年份:2001
-
负责人:KOTTAYIL I VARUGHESE
-
依托单位:
CRYSTAL STRUCTURE OF VON WILLEBRAND FACTOR A1 DOMAIN
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批准号:6119419
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项目类别:
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资助金额:$0.0万
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财政年份:1999
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负责人:KOTTAYIL I VARUGHESE
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依托单位:
STRUCTURE OF SPORULATION PROTEINS IN B SUBTILIS
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批准号:2023350
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项目类别:
-
资助金额:$22.18万
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财政年份:1997
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负责人:KOTTAYIL I VARUGHESE
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依托单位:
STRUCTURE OF SPORULATION PROTEINS IN B SUBTILIS
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批准号:2634806
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项目类别:
-
资助金额:$22.32万
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财政年份:1997
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负责人:KOTTAYIL I VARUGHESE
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依托单位:
海外基金