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CRYSTALLOGRAPHIC STRUCTURE DETERMINATION OF PRO REGION OF A LYTIC PROTEASE

CRYSTALLOGRAPHIC STRUCTURE DETERMINATION OF PRO REGION OF A LYTIC PROTEASE
裂解蛋白酶 PRO 区域的晶体结构测定
批准号：
6586614
负责人：
NICHOLAS K SAUTER
金额：
$14.32万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
项目状态：
已结题
起止时间：
2002-03-01 至 2003-02-28
来源：
https://reporter.nih.gov/project-details/6586614
关键词：
bioimaging /biomedical imaging biomaterials biomedical resource proteins radiography structural biology

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Proper function of a-lytic protease requires the presence of its N-terminal pro region, which catalyzes an as yet unidentified step in the folding of this enzyme. In order to better understand the folding mechanism, we are using x-ray crystallography to determine the structure of the pro region, both by itself and in a complex with folded protease. We have engineered several mutants containing cysteines to facilitate the preparation of heavy atom derivatives for multiple isomorphous replacement.
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