XRAY CRYSTALLOGRAPHIC STUDY OF DRUG DESIGN TARGETS

涉及蛋白质结构测定的三个项目 是药物设计的目标。它们是细菌细胞壁的合成体 酶(MurB)与微粒体甘油三酯转运蛋白(MTP) 在我们的实验室中，它们仍然是高度优先的。第三 人巨细胞病毒(HCMV)蛋白是一种新的蛋白。这其中的每一个 项目涉及使用三维结构信息 帮助设计新的治疗剂。在每种情况下， 目标是抑制一种新的蛋白质靶点。每一种结构 项目提出了独特的挑战，需要使用 用于数据收集的同步辐射。

Three projects involving structure determinations of proteins that are drug design targets. They are a bacterial cell wall synthesis enzyme (MurB) and the microsomal triglyceride transfer protein (MTP) and they remain at high priority in our laboratory. The third protein, human cytomegalovirus (HCMV) protease, is new. Each of these projects involves the use of three-dimensional structural information to aid in the design of new therapeutic agents. In each case, the goal is to inhibit a novel protein target. Each of these structure projects presents unique challenges that require the use of synchrotron radiation for data collection.