XRAY DATA COLLECTION ON HERPES MATURATION PROTEASE

疱疹病毒编码66 kDa的蛋白质，称为 成熟蛋白酶(HMP)，这是病毒复制所必需的。 由该酶产生的组装蛋白的C末端加工 聚集形成衣壳的活性组装蛋白质分子 脚手架。当衣壳形成完成后，蛋白酶就会 破坏脚手架，允许病毒基因组进入 新形成的衣壳。HMPs的高度序列同源性表明 HMP的催化域的结构将类似于 疱疹病毒。因此，HMP的催化域的结构 从巨细胞病毒中分离出来的HMP将为其他HMP在 疱疹家族。

Herpes viruses encode a 66 kDa protein, referred to as the maturation protease (HMP), which is essential for viral replication. C-terminal processing of the assembly protein by the protease produces active assembly protein molecules which aggregate to form the capsid scaffold. When capsid formation is complete, the protease then destroys the scaffolding, allowing entry of the viral genome into the newly formed capsid. High sequence homology of HMPs indicates that the structure of the catalytic domain of HMP will be similar among Herpes viruses. Thus, the structure of the catalytic domain of HMP from cytomegalovirus will provide a model for other HMP's in the Herpes family.