Oral Health Outcomes in Pediatric Transplant Recipients

儿童移植受者的口腔健康结果

• 批准号: 6677961
• 负责人: CAROLINE Helene SHIBOSKI
• 金额: $ 7.58万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-01 至 2005-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6677961
• 关键词: adolescence (12-20); child (0-11); clinical research; dental disorder; gingiva disorder; human subject; immunosuppressive; kidney transplantation; liver transplantation; longitudinal human study; oral health; oral mucosa; outcomes research; patient oriented research; sirolimus; socioeconomics; transplantation immunology

DESCRIPTION (provided by applicant): We propose to conduct a study to explore specific oral health outcomes in relation to new generation immunosuppressants in a population of pediatric renal transplant recipients (RTRs) and liver transplant recipients (LTRs) at UCSF. Oral health outcomes of interest include mucosal diseases (e.g., candidiasis, hairy leukoplakia, ulcers, warts, lip carcinoma, non-Hodgkin's lymphoma, and Kaposi's sarcoma (KS), gingival enlargement (GE), and dental needs. The principal investigator of the proposed study is a recipient of a K23 award that bears as its central theme the study of oral health outcomes among adult RTRs. Dr. Shiboski also received a small amount of pilot funds to study utilization of dental care among medically compromised children. As part of this pilot project she has been recruiting, and administering oral health questionnaires to pediatric RTRs and LTRs at UCSF. Taking advantage of this developing research infrastructure, the goal of the present application is to request funds to conduct a prospective study among pediatric RTRs and LTRs, exploring specific oral health outcomes by following these children at 6-months intervals over a 2-year period. The Specific Aims of the proposed study among pediatric RTRs and LTRs are: a. To estimate the prevalence and incidence of oral mucosal diseases and GE in relation to new immunosuppressive drug regimens, type of transplant, and time since transplant surgery; b. To estimate the prevalence of unmet dental need in relation to socio-demographic variables and time since transplant surgery; c. To collect preliminary data on any potential association between unmet dental needs (e.g., advanced caries, chronic gingival inflammation associated with GE) and history of acute graft rejection episode(s).

描述（由申请人提供）：我们建议进行一项研究，以探索在UCSF的儿科肾移植受者（RTRs）和肝移植受者（LTR）人群中与新一代免疫抑制剂相关的特定口腔健康结局。感兴趣的口腔健康结果包括粘膜疾病（例如，念珠菌病、毛状白斑、溃疡、疣、唇癌、非霍奇金淋巴瘤和卡波西肉瘤（KS）、牙龈肿大（GE）和牙科需要。拟议研究的主要研究者是K23奖的获得者，该奖项的中心主题是研究成人RTR中的口腔健康结果。Shiboski博士还获得了少量试点资金，用于研究医疗受损儿童对牙科护理的利用。作为这个试点项目的一部分，她一直在招募，并管理口腔健康问卷儿科RTRs和LTR在加州大学旧金山分校。 利用这种发展中的研究基础设施，本申请的目标是请求资金在儿科RTR和LTR中进行前瞻性研究，通过在2年的时间内以6个月的间隔跟踪这些儿童来探索特定的口腔健康结果。 在儿科RTR和LTR中进行的拟定研究的具体目的是： a. 评估口腔粘膜疾病和GE的患病率和发病率与新的免疫抑制药物治疗方案、移植类型和移植手术后时间的关系; B. 估计与社会人口统计学变量和移植手术后时间相关的未满足牙科需求的患病率; C. 收集未满足牙科需求之间任何潜在关联的初步数据（例如，晚期龋齿、与GE相关的慢性牙龈炎症）和急性移植物排斥发作史。