Oral Health Outcomes in Pediatric Transplant Recipients

儿童移植受者的口腔健康结果

• 批准号: 6781102
• 负责人: CAROLINE Helene SHIBOSKI
• 金额: $ 7.58万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-01 至 2007-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6781102
• 关键词: adolescence (12-20); child (0-11); clinical research; dental disorder; gingiva disorder; human subject; immunosuppressive; kidney transplantation; liver transplantation; longitudinal human study; oral health; oral mucosa; outcomes research; patient oriented research; sirolimus; socioeconomics; transplantation immunology

DESCRIPTION (provided by applicant): We propose to conduct a study to explore specific oral health outcomes in relation to new generation immunosuppressants in a population of pediatric renal transplant recipients (RTRs) and liver transplant recipients (LTRs) at UCSF. Oral health outcomes of interest include mucosal diseases (e.g., candidiasis, hairy leukoplakia, ulcers, warts, lip carcinoma, non-Hodgkin's lymphoma, and Kaposi's sarcoma (KS), gingival enlargement (GE), and dental needs. The principal investigator of the proposed study is a recipient of a K23 award that bears as its central theme the study of oral health outcomes among adult RTRs. Dr. Shiboski also received a small amount of pilot funds to study utilization of dental care among medically compromised children. As part of this pilot project she has been recruiting, and administering oral health questionnaires to pediatric RTRs and LTRs at UCSF. Taking advantage of this developing research infrastructure, the goal of the present application is to request funds to conduct a prospective study among pediatric RTRs and LTRs, exploring specific oral health outcomes by following these children at 6-months intervals over a 2-year period. The Specific Aims of the proposed study among pediatric RTRs and LTRs are: a. To estimate the prevalence and incidence of oral mucosal diseases and GE in relation to new immunosuppressive drug regimens, type of transplant, and time since transplant surgery; b. To estimate the prevalence of unmet dental need in relation to socio-demographic variables and time since transplant surgery; c. To collect preliminary data on any potential association between unmet dental needs (e.g., advanced caries, chronic gingival inflammation associated with GE) and history of acute graft rejection episode(s).

描述(由申请人提供)：我们建议在加州大学旧金山分校进行一项研究，以探索新一代免疫抑制剂对儿童肾移植受者(RTR)和肝移植受者(LTRS)人群的特定口腔健康结果。值得关注的口腔健康结果包括粘膜疾病(例如，念珠菌病、毛发白斑、溃疡、疣、唇癌、非霍奇金淋巴瘤和卡波西氏肉瘤(KS)、牙龈增大(GE)和牙科需求)。这项拟议研究的首席研究员是K23奖的获得者，该奖项的中心主题是成人RTR中口腔健康结果的研究。柴博斯基博士还获得了一小笔试点资金，用于研究健康受损儿童对牙科保健的利用情况。作为这一试点项目的一部分，她一直在向加州大学旧金山分校的儿科RTR和LTRS招募和管理口腔健康问卷。 利用这一发展中的研究基础设施，本申请的目标是申请资金，在儿科RTR和LTRS中进行一项前瞻性研究，通过在两年期间每隔6个月对这些儿童进行跟踪调查，探索具体的口腔健康结果。 建议在儿科RTR和LTRS之间进行的研究的具体目标是： A.评估口腔粘膜疾病和GE的患病率和发病率与新的免疫抑制药物方案、移植类型和自移植手术以来的时间的关系； B.评估未满足的牙科需求与社会人口学变量和自移植手术以来的时间的关系； C.收集未得到满足的牙科需求(例如，晚期龋齿、与GE相关的慢性牙周炎)与移植急性排斥事件病史之间的任何潜在关联的初步数据(S)。