ORAL DISEASE AMONG RENAL TRANSPLANT RECIPIENTS

肾移植受者的口腔疾病

• 批准号: 6516345
• 负责人: CAROLINE Helene SHIBOSKI
• 金额: $ 12.29万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-05-01 至 2006-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6516345
• 关键词: artificial immunosuppression; clinical research; epidemiology; human subject; kidney transplantation; oral health

During this 5-year career development award Dr. Shiboski intends to integrate a study of oral disease in renal transplant recipients (RTRs) with further training in molecular epidemiology and immunology that would complement her background in general epidemiology and oral medicine. Dr. Shiboski proposes to recruit and follow over a 5-year period a cohort of RTRs to investigate the incidence of oral soft tissue disease in relation to 1) biological factors (time since transplantation, immunosuppressive regimen, diabetes); and 2) socio-demographic / behavioral factors (race, gender, dental insurance, dental care utilization). A secondary objective will be to identify the co-factors (predisposing, enabling, and need) that may explain dental care utilization in this population. RTRs (N = 360) will be recruited from the UCSF kidney post-transplant clinic, and followed at 1-year intervals. Measurements will include an oral soft tissue examination, evaluation of periodontal parameters, vertical bitewing radiographs, assessment of oral treatment needs, and an interview. Participants will be examined at the UCSF Stomatology Clinical Center. This study is the first and necessary step for the development of subsequent studies to investigate how oral disease may relate to graft outcomes and systemic conditions within this group of medically compromised patients. The training aspect of the award will be under the guidance of two mentors and a clinical adviser. Dr. John Greenspan will assist the candidate in learning aspects of molecular immunopathology and immunohistochemistry that are relevant to her research area. Dr. Ira Tager will advise the candidate about methodologic difficulties inherent in a longitudinal study of immunosuppressed subjects with complex medical histories. Dr. Laurie MacPhail, who received a Mid-career Investigator Award in Patient-Oriented Research (K24) in 1999, will act as clinical adviser to Dr. Shiboski. The candidate earned a PhD in epidemiology from the University of California, Berkeley, and received post-graduate training in oral medicine at UCSF as part of an individual Dentist Scientist Award. The proposed career development award would allow Dr. Shiboski to evolve from the post-doctoral level to the level of independent investigator. The candidate intends to devote 80 percent effort to the proposed project.

Shiboski 博士打算在这个为期 5 年的职业发展奖中 将肾移植受者 (RTR) 口腔疾病的研究与 分子流行病学和免疫学方面的进一步培训将补充 她的普通流行病学和口腔医学背景。 Shiboski博士建议 招募并在 5 年时间内跟踪一组 RTR 来调查 口腔软组织疾病的发病率与 1) 生物因素有关 （移植后的时间、免疫抑制疗法、糖尿病）；和 2) 社会人口/行为因素（种族、性别、牙科保险、牙科 护理利用）。次要目标是确定辅助因素 （倾向、促成和需要）可以解释牙科护理的利用 这个人口。 RTR（N = 360）将从 UCSF 肾脏招募 移植后门诊，并每隔 1 年进行一次随访。测量结果将 包括口腔软组织检查、牙周参数评估、 垂直咬翼X光片、口腔治疗需求评估以及 面试。参与者将在 UCSF 口腔临床临床中心接受检查 中心。这项研究是发展的第一步，也是必要的一步。 随后的研究调查口腔疾病与移植结果的关系 以及这组医学受损患者的全身状况。 该奖项的培训方面将在两位导师的指导下进行 临床顾问。约翰·格林斯潘博士将协助候选人学习 相关的分子免疫病理学和免疫组织化学方面 到她的研究领域。 Ira Tager 博士将为候选人提供以下建议 免疫抑制纵向研究固有的方法学困难 具有复杂病史的受试者。劳里·麦克菲尔博士 (Laurie MacPhail) 获得了 1999 年以患者为导向的研究 (K24) 职业生涯中期研究员奖 担任 Shiboski 博士的临床顾问。该候选人获得了博士学位 加州大学伯克利分校流行病学博士，并获得 作为个人的一部分，在 UCSF 进行口腔医学研究生培训 牙医科学家奖。拟议的职业发展奖将允许博士。 Shiboski从博士后层次进化到独立水平 研究者。候选人打算将 80% 的精力投入到所提议的项目上 项目。