ORAL DISEASE AMONG RENAL TRANSPLANT RECIPIENTS

肾移植受者的口腔疾病

• 批准号: 6266166
• 负责人: CAROLINE Helene SHIBOSKI
• 金额: $ 12.26万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-05-01 至 2006-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6266166
• 关键词: artificial immunosuppression; clinical research; epidemiology; human subject; kidney transplantation; oral health

During this 5-year career development award Dr. Shiboski intends to integrate a study of oral disease in renal transplant recipients (RTRs) with further training in molecular epidemiology and immunology that would complement her background in general epidemiology and oral medicine. Dr. Shiboski proposes to recruit and follow over a 5-year period a cohort of RTRs to investigate the incidence of oral soft tissue disease in relation to 1) biological factors (time since transplantation, immunosuppressive regimen, diabetes); and 2) socio-demographic / behavioral factors (race, gender, dental insurance, dental care utilization). A secondary objective will be to identify the co-factors (predisposing, enabling, and need) that may explain dental care utilization in this population. RTRs (N = 360) will be recruited from the UCSF kidney post-transplant clinic, and followed at 1-year intervals. Measurements will include an oral soft tissue examination, evaluation of periodontal parameters, vertical bitewing radiographs, assessment of oral treatment needs, and an interview. Participants will be examined at the UCSF Stomatology Clinical Center. This study is the first and necessary step for the development of subsequent studies to investigate how oral disease may relate to graft outcomes and systemic conditions within this group of medically compromised patients. The training aspect of the award will be under the guidance of two mentors and a clinical adviser. Dr. John Greenspan will assist the candidate in learning aspects of molecular immunopathology and immunohistochemistry that are relevant to her research area. Dr. Ira Tager will advise the candidate about methodologic difficulties inherent in a longitudinal study of immunosuppressed subjects with complex medical histories. Dr. Laurie MacPhail, who received a Mid-career Investigator Award in Patient-Oriented Research (K24) in 1999, will act as clinical adviser to Dr. Shiboski. The candidate earned a PhD in epidemiology from the University of California, Berkeley, and received post-graduate training in oral medicine at UCSF as part of an individual Dentist Scientist Award. The proposed career development award would allow Dr. Shiboski to evolve from the post-doctoral level to the level of independent investigator. The candidate intends to devote 80 percent effort to the proposed project.

在这个为期5年的职业发展奖，Shiboski博士打算 将肾移植受者（RTRs）口腔疾病的研究与 分子流行病学和免疫学方面的进一步培训， 她在普通流行病学和口腔医学方面的背景。希博斯基博士建议 招募一组RTR并随访5年，以调查 口腔软组织疾病发病率与1）生物学因素 (time由于移植、免疫抑制方案、糖尿病）;和2） 社会人口统计学/行为因素（种族、性别、牙科保险、 护理利用）。第二个目标是确定辅助因素 （易感性，使能性和需要），这可能解释了 这个人口。将从UCSF肾脏招募RTR（N = 360） 移植后门诊，并随访1年的时间间隔。测量将 包括口腔软组织检查、牙周参数评估 垂直咬翼片，口腔治疗需求评估，以及 采访参与者将在UCSF口腔临床检查 中心这项研究是发展的第一步，也是必要的一步。 随后的研究调查口腔疾病如何与移植结果相关 以及这组医学受损患者的全身状况。 该奖项的培训方面将在两名导师的指导下进行， 临床顾问约翰·格林斯潘博士将协助候选人学习 分子免疫病理学和免疫组织化学方面， 她的研究领域。伊拉泰格医生会建议候选人 免疫抑制的纵向研究中固有的方法学困难 有复杂病史的人劳里麦克菲尔博士，谁收到了 1999年获得以患者为导向的研究（K24）职业中期研究者奖， 担任希博斯基医生的临床顾问这位候选人获得博士学位， 流行病学从加州大学伯克利分校，并收到 在加州大学旧金山分校口腔医学研究生培训作为个人的一部分， 牙科科学家奖。拟议的职业发展奖将允许博士。 希博斯基从博士后水平发展到独立水平 调查员候选人打算把80%的精力投入到拟议的 项目