ORAL DISEASE AMONG RENAL TRANSPLANT RECIPIENTS

在这个为期5年的职业发展奖期间，柴博斯基博士打算 将一项关于肾移植受者口腔疾病的研究与 分子流行病学和免疫学方面的进一步培训将补充 她有普通流行病学和口腔医学的背景。柴博斯基博士建议 招募和跟踪一批RTR在5年内调查 口腔软组织病的发病率与1)生物因素有关 (自移植以来的时间、免疫抑制方案、糖尿病)；以及2) 社会人口/行为因素(种族、性别、牙科保险、牙科 护理利用)。次要目标将是确定共同因素 (易感、使能和需要)，这可能解释了在 这群人。RTR(N=360)将从加州大学旧金山分校的肾脏招募 移植后门诊，每隔1年进行一次随访。测量结果将 包括口腔软组织检查、牙周参数评估 垂直咬合X光片，口腔治疗需求评估，以及 面试。参与者将在加州大学旧金山分校的口腔诊所接受检查 中心。这项研究是发展的第一步，也是必要的一步 随后的研究调查口腔疾病可能如何与移植结果相关 以及这组医学上有问题的患者的全身状况。 该奖项的培训方面将在两名导师和 临床顾问。约翰·格林斯潘博士将帮助候选人学习 分子免疫病理学和免疫组织化学的相关方面 去她的研究领域。艾拉·泰格博士将为候选人提供以下建议 免疫抑制纵向研究中固有的方法学困难 有复杂病史的受试者。Laurie MacPhail博士，他收到了 1999年以患者为中心的研究的职业中期研究员奖(K24)，将 担任柴博斯基医生的临床顾问。这位候选人获得了博士学位。 来自加州大学伯克利分校的流行病学，并收到 作为个人在加州大学旧金山分校接受口腔医学研究生培训 牙医科学家奖。拟议的职业发展奖将允许Dr。 柴博斯基将从博士后水平演变到独立水平 调查员。候选人打算将80%的精力投入到提议的 项目。

During this 5-year career development award Dr. Shiboski intends to integrate a study of oral disease in renal transplant recipients (RTRs) with further training in molecular epidemiology and immunology that would complement her background in general epidemiology and oral medicine. Dr. Shiboski proposes to recruit and follow over a 5-year period a cohort of RTRs to investigate the incidence of oral soft tissue disease in relation to 1) biological factors (time since transplantation, immunosuppressive regimen, diabetes); and 2) socio-demographic / behavioral factors (race, gender, dental insurance, dental care utilization). A secondary objective will be to identify the co-factors (predisposing, enabling, and need) that may explain dental care utilization in this population. RTRs (N = 360) will be recruited from the UCSF kidney post-transplant clinic, and followed at 1-year intervals. Measurements will include an oral soft tissue examination, evaluation of periodontal parameters, vertical bitewing radiographs, assessment of oral treatment needs, and an interview. Participants will be examined at the UCSF Stomatology Clinical Center. This study is the first and necessary step for the development of subsequent studies to investigate how oral disease may relate to graft outcomes and systemic conditions within this group of medically compromised patients. The training aspect of the award will be under the guidance of two mentors and a clinical adviser. Dr. John Greenspan will assist the candidate in learning aspects of molecular immunopathology and immunohistochemistry that are relevant to her research area. Dr. Ira Tager will advise the candidate about methodologic difficulties inherent in a longitudinal study of immunosuppressed subjects with complex medical histories. Dr. Laurie MacPhail, who received a Mid-career Investigator Award in Patient-Oriented Research (K24) in 1999, will act as clinical adviser to Dr. Shiboski. The candidate earned a PhD in epidemiology from the University of California, Berkeley, and received post-graduate training in oral medicine at UCSF as part of an individual Dentist Scientist Award. The proposed career development award would allow Dr. Shiboski to evolve from the post-doctoral level to the level of independent investigator. The candidate intends to devote 80 percent effort to the proposed project.