New genetic vaccine to protect aganist botulism

新型基因疫苗可保护无肉毒杆菌中毒

基本信息

  • 批准号:
    6673546
  • 负责人:
  • 金额:
    $ 31.5万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2003
  • 资助国家:
    美国
  • 起止时间:
    2003-08-01 至 2005-07-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Botulism is a severe neuroparalytic disease caused by one of seven botulinum neurotoxins (BoNTs), produced by the anaerobic, spore-forming bacterium Clostridium botulinum. These protein neurotoxins are the most potent toxins known to man. There are BoNT toxoid vaccines available currently as Investigational New Drugs. However, due to the numerous shortcomings associated with the toxoid vaccines (i.e., dangerous to produce, high cost of manufacturing, high reactogenicity), there is an urgent need to develop new generation vaccines for the prevention of botulism. The goals of this research are to develop a new botulism vaccine using the carboxyl-terminal 50 kDa C-fragments (Hc) of the heavy chains in BoNTs as antigens and to study the delivery of the vaccine utilizing a replication-defective adenoviral vector via the intranasal and transcutaneous routes. These non-invasive vaccine delivery methods will undoubtedly enhance the compliance of a vaccination program, which is especially critical in response to a potential bioterrorist attack using BoNTs. After construction of replication-defective adenoviral vectors encoding the immunogenic C-fragments of the heavy chains in BoNTs, vaccination protocols in mice comparing the intranasal and transcutaneous delivery modes with the subcutaneous injection of the currently available pentavalent botulinum toxoid vaccine (PBT) will be studied. The specific aims of this project are: Specific Aim #1: To construct replication-defective adenoviral vectors encoding the C-fragments of the heavy chains in BoNTs. Specific Aim #2: To study the mucosal and systemic immunity elicited by the vectored vaccine developed in aim #1 through intranasal and transcutaneous immunization in a mouse model.
描述(由申请人提供):肉毒中毒是由七种肉毒杆菌神经毒素(BoNTs)之一引起的严重神经麻痹疾病,由厌氧芽孢形成细菌肉毒梭菌产生。这些蛋白质神经毒素是人类已知的最有效的毒素。目前有BoNT类毒素疫苗作为研究新药。然而,由于与类毒素疫苗相关的许多缺点(即生产危险、制造成本高、高反应原性),迫切需要开发新一代预防肉毒杆菌中毒的疫苗。本研究的目的是利用bont重链的羧基末端50 kDa c片段(Hc)作为抗原,开发一种新的肉毒杆菌中毒疫苗,并研究利用复制缺陷腺病毒载体通过鼻内和经皮途径给药。这些非侵入性的疫苗递送方法无疑将提高疫苗接种计划的依从性,这对于应对使用bont的潜在生物恐怖袭击尤其重要。在构建了复制缺陷腺病毒载体,编码bont重链的免疫原性c片段后,将研究小鼠的疫苗接种方案,比较鼻内和经皮递送方式与皮下注射目前可用的五价肉毒杆菌类毒素疫苗(PBT)。该项目的具体目标是:

项目成果

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MINGTAO ZENG其他文献

MINGTAO ZENG的其他文献

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{{ truncateString('MINGTAO ZENG', 18)}}的其他基金

New Nasal Spray Influenza Vaccine for Children (Research Supplement for Post Baccalaureate Diversity Candidate)
儿童新型鼻喷雾流感疫苗(学士学位后多样性候选人的研究补充)
  • 批准号:
    10838135
  • 财政年份:
    2023
  • 资助金额:
    $ 31.5万
  • 项目类别:
New Nasal Spray Influenza Vaccine for Children
新型儿童鼻喷雾流感疫苗
  • 批准号:
    10653579
  • 财政年份:
    2023
  • 资助金额:
    $ 31.5万
  • 项目类别:
Targeted-delivery of small interference RNA against anthrax (1 R21 AI118228-01A1)
针对炭疽病的小干扰 RNA 的靶向递送(1 R21 AI118228-01A1)
  • 批准号:
    9152506
  • 财政年份:
    2016
  • 资助金额:
    $ 31.5万
  • 项目类别:
Targeted-delivery of small interference RNA against anthrax
针对炭疽病的小干扰 RNA 的靶向递送
  • 批准号:
    8986413
  • 财政年份:
    2015
  • 资助金额:
    $ 31.5万
  • 项目类别:
Targeted-delivery of small interference RNA against anthrax
针对炭疽病的小干扰 RNA 的靶向递送
  • 批准号:
    9089923
  • 财政年份:
    2015
  • 资助金额:
    $ 31.5万
  • 项目类别:
New Vaccine against Influenza
新型流感疫苗
  • 批准号:
    7929638
  • 财政年份:
    2009
  • 资助金额:
    $ 31.5万
  • 项目类别:
New Vaccine against Influenza
新型流感疫苗
  • 批准号:
    7582690
  • 财政年份:
    2009
  • 资助金额:
    $ 31.5万
  • 项目类别:
New Vaccine against Influenza
新型流感疫苗
  • 批准号:
    8146178
  • 财政年份:
    2009
  • 资助金额:
    $ 31.5万
  • 项目类别:
Development of a New Tularemia Vaccine
新型兔热病疫苗的开发
  • 批准号:
    6867665
  • 财政年份:
    2005
  • 资助金额:
    $ 31.5万
  • 项目类别:
Development of a New Tularemia Vaccine
新型兔热病疫苗的开发
  • 批准号:
    7093546
  • 财政年份:
    2005
  • 资助金额:
    $ 31.5万
  • 项目类别:

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