Diet and regulatory control of uterine contractions during labour (focus on maternal obesity).

分娩期间子宫收缩的饮食和调节控制（重点关注产妇肥胖）。

• 批准号: 2275869
• 金额: --
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2275869
• 关键词: Diet; regulatory; control; uterine; contractions

Maternal obesity rates will be 50% by 2050 and associated pregnancy complications will rise significantly, particularly the increased risk of prolonged and dysfunctional labour and emergency caesarean delivery. Poor uterine activity is a key component of this increased risk but the biological mechanism is yet to be identified and is a key focus of this study. Obesity is associated with diets high in cholesterol, saturated fat and omega-6 polyunsaturated fatty acids (PUFAs) but low in omega-3 PUFAs. The level of omega-6 and omega-3 PUFAs in the diet is important because they produce hormones (prostaglandins) that regulate uterine contractions and cervical dilation during labour. As a result weak uncoordinated contractions and prolonged labour seen in obese pregnant women may result from the level of omega-6 and omega-3 PUFAs consumed in their diet. This PhD project will determine whether uncoordinated contractions and prolonged labour caused by a HFHC diet can be prevented by increasing consumption of PUFA during pregnancy, Uterine and placental tissues and plasma obtained from our animal model of obesity alongside human biopsy samples and plasma from women will be used. Uterine and placental tissue will be used in contractility studies and for quantification of proteins and genes that regulate contractile activity. Plasma samples will be used to quantify circulating lipids and fatty acids but also prostaglandin and steroid hormones key to labour. This approach will determine the regulatory role of PUFAs on uterine contractions and the timing and length of labour.

到2050年，产妇肥胖率将达到50%，与此相关的妊娠并发症将显著增加，特别是分娩时间延长和功能失调以及紧急剖腹产的风险增加。子宫活动不良是这种风险增加的关键因素，但生物学机制尚未确定，这是本研究的重点。肥胖与高胆固醇、饱和脂肪和ω-6多不饱和脂肪酸（PUFA）但低ω-3 PUFA的饮食有关。饮食中omega-6和omega-3 PUFA的水平很重要，因为它们产生调节分娩过程中子宫收缩和宫颈扩张的激素（Escherlandins）。因此，在肥胖孕妇中看到的不协调的弱收缩和长时间的劳动可能是由于他们饮食中消耗的omega-6和omega-3 PUFA水平。该博士项目将确定是否可以通过增加怀孕期间PUFA的摄入量来预防HFHC饮食引起的不协调收缩和产程延长，将使用从我们的肥胖动物模型中获得的子宫和胎盘组织以及血浆以及人类活检样本和女性血浆。子宫和胎盘组织将用于收缩性研究，并用于定量调节收缩活性的蛋白质和基因。血浆样本将用于定量循环脂质和脂肪酸，以及对分娩至关重要的前列腺素和类固醇激素。这种方法将确定PUFAs对子宫收缩以及分娩时间和长度的调节作用。