"Polymer processing for organ-on-a-chip devices'

“芯片器官装置的聚合物加工”

• 批准号: 2276778
• 金额: --
• 依托单位: University of Sheffield
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2276778
• 关键词: Polymer; processing; organ; chip; devices

Microfluidic-based tissue-on-a-chip devices have generated significant research interest for biomedical applications, with a great potential for uses within pharmaceutical development. Recent advances within the area have seen these devices evolve from basic 2D cell cultures, into a push towards the design and fabrication of microfluidic 3D devices. The 3D microenvironment seen in in vivo tissue assists greatly in a cells morphology, polarity, and behaviour, meaning that for a truly accurate model, it must be designed in a way that can recapitulate this dynamic and mechanical environment of the native tissue.These devices have the potential to provide a more sensitive and accurate assay in comparison to animal testing, where fundamental differences within animal and human physiology and immune systems result in a difficult translation of results. Not only would the use of organ-on-a-chip technologies see to assist with speeding up the process of pharmaceutical design and approval, it aligns with the principles of the 3Rs of animal testing - reducing, refining and replacing animal testing, providing a more ethical solution to standard protocols. With these reasons considered, this project to be focused on an extremely meaningful and important area of medical science that needs to be addressed.

基于微流控的芯片组织设备引起了生物医学应用的巨大研究兴趣，在药物开发中具有巨大的应用潜力。该领域的最新进展见证了这些设备从基本的 2D 细胞培养演变为微流体 3D 设备的设计和制造的推动力。体内组织中看到的 3D 微环境对细胞的形态、极性和行为有很大帮助，这意味着对于真正准确的模型，它的设计必须能够重现天然组织的这种动态和机械环境。与动物测试相比，这些设备有可能提供更灵敏和更准确的测定，因为动物和人类生理学和免疫系统之间的根本差异导致难以翻译 结果。器官芯片技术的使用不仅有助于加快药物设计和审批过程，而且符合动物试验的 3R 原则——减少、改进和替代动物试验，为标准方案提供更合乎道德的解决方案。考虑到这些原因，该项目将重点关注需要解决的极其有意义和重要的医学科学领域。