CORE--BIOSTATISTICS AND RECRUITMENT

核心--生物统计与招聘

• 批准号: 6716894
• 负责人: GREG MAISLIN
• 金额: $ 42.29万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-15 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6716894
• 关键词: biomedical facility; computer data analysis; data management; information systems; medical outreach /case finding; method development; neurobiology; sleep; sleep apnea; statistical service /center; statistics /biometry

The Biostatistical and Recruitment Core (formally, Human Assessment and Biostatistics Core) will continue to play an integral role as part of the Special Center of Research in Neurobiology of Sleep and Sleep Apnea. The Core's specific aims (functions) are: 1) to meet the biostatistical needs of the two human study projects and two animal projects providing innovative solutions to data analysis challenges arising from these projects (all projects); 2) to provide centralized statistical programming and data management resources to the human projects (Projects by Weaver and Kuna and; 3) to apply existing methods and to make substantial contributions to the development of optimal statistical methods related to defining phenotypic characteristics associated with genetic control of homeostatic sleep regulation (Projects by Weaver and Kuna; 4) to support database management infrastructure development for the human and animal (all projects); 5) to promote the sound use of statistical principles and experimental design by all SCOR investigators (all projects); and 6) to provide the recruitment infrastructure enabling recruitment of apnea patients (Project by Weaver) and twins (Project by Kuna), the latter to be facilitated through a partnership with an existing twin cohort (PennTwins, E. Coccaro). Core C (Biostatistical and Recruitment Core) is comprised of a very experienced team of biostatisticians, statistical programmers, database managers, and clinical recruitment personnel. There exists a long history of collaboration among Core C staff and between Core C staff and SCOR investigators. The Core Leader of Core C has been SCOR biostatistician since its inception in 1988 and Core Leader since 1990. He has an extensive record of collaboration with SCOR investigators as well as original research in the field of sleep. The Core Leader (Senior Biostatistician) will be assisted by an Associate Biostatistician whose focus will be on providing biostatistical support to the animal studies and who is experienced in applying the mixed effects statistical models appropriate for the experimental designs proposed for these projects. Core C also includes a senior SAS TM statistical programmer with a longtime association with the Core who specializes in the development of analysis systems for implementation of complex statistical models that utilize data from multiple sources, an experienced database manager/statistical programmer with expertise in Access database development, and a data clerk. In addition, the Core Leader will be assisted by an experienced senior clinical study recruiter who will direct the human studies recruitment function, provide liaison with the PennTwins Cohort, and who will be assisted by additional recruitment staff. The experience, scientific interest, and long history of collaboration with SCOR investigators make the Biostatistical and Recruitment Core well-positioned to provide state-of-the-art statistical, database management, and human studies recruitment support to the projects while contributing to the advancement of statistical methods necessary to address the specific aims of the projects.

生物统计和招募核心（正式名称为人类评估和生物统计核心）将继续作为睡眠和睡眠呼吸暂停神经生物学研究特别中心的一部分发挥不可或缺的作用。核心的具体目标（功能）是：1)满足两个人类研究项目和两个动物研究项目的生物统计需求，为这些项目（所有项目）产生的数据分析挑战提供创新的解决方案；2)为人类项目（Weaver和Kuna的项目）提供集中的统计编程和数据管理资源；3)应用现有方法，并为开发与定义与稳态睡眠调节遗传控制相关的表型特征相关的最佳统计方法做出实质性贡献（Weaver和Kuna的项目）；4)支持人类和动物的数据库管理基础设施开发（所有项目）；5)促进所有SCOR研究者（所有项目）对统计原理和实验设计的合理使用；6)提供招募基础设施，以便招募呼吸暂停患者（Weaver项目）和双胞胎（Kuna项目），后者将通过与现有双胞胎队列（PennTwins， E. Coccaro）的合作来促进。Core C（生物统计和招聘核心）由经验丰富的生物统计学家、统计程序员、数据库管理人员和临床招聘人员组成。核心C员工之间以及核心C员工与SCOR调查人员之间的合作有着悠久的历史。Core C的核心领导者自1988年成立以来一直担任SCOR生物统计学家，自1990年以来一直担任核心领导者。他与SCOR研究人员有着广泛的合作记录，并在睡眠领域进行了原创研究。核心领导（高级生物统计学家）将由一名助理生物统计学家协助，他的重点是为动物研究提供生物统计支持，并在应用适合这些项目的实验设计的混合效应统计模型方面经验丰富。Core C还包括一位资深的SAS TM统计程序员，他长期与Core合作，专门开发分析系统，用于实现利用多个来源数据的复杂统计模型，一位经验丰富的数据库管理员/统计程序员，拥有Access数据库开发的专业知识，以及一名数据文员。此外，核心负责人将由一位经验丰富的资深临床研究招聘人员协助，他将指导人体研究招聘工作，并与宾夕法尼亚双胞胎大学队列进行联络