BIOSTATISTICS AND DATA BASE CORE

生物统计学和数据库核心

• 批准号: 8251140
• 负责人: GREG MAISLIN
• 金额: $ 22.18万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-03-15 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8251140
• 关键词: Address; Adopted; Age; Animal Model; Animals; Archives; Attention; Behavior; Behavior assessment; Behavioral; Biometry; Classification; Communities; Computer software; Coupled; Data; Data Analyses; Databases; Detection; Documentation; Drosophila genus; Electroencephalography; Ensure; Exclusion; Exhibits; Funding; Goals; Human Resources; Industry; Internet; Longevity; Manuscripts; Metadata; Methodology; Methods; Mus; Operations Research; Operative Surgical Procedures; Outcome Measure; Population; Preparation; Progress Reports; Research; Research Design; Research Infrastructure; Research Personnel; Research Support; Residual state; Resources; Rodent; Role; Sample Size; Schools; Screening procedure; Sleep; Statistical Methods; System; Thinking; Work; data integration; data management; data modeling; data sharing; database structure; design; implantation; meetings; middle age; novel; programs; research study; sound; statistics; success; web site; web-enabled

The overall goal of this Core is to provide biostatistical and data base support to the four projects in the Program Project and to the investigators and staff of Core B: BehavioralAssessment Core and to facilitate dissemination ofgenotypic and phenotypic data arising from animal models of sleep in both young and older animals to the larger scientific community (data sharing). To accomplish this goal, the Core will do the following: i. Work with investigators to develop robust study designs, clarify hypotheses, determine sample sizes for experiments to be performed, and to promote statistical thinking and the valid application of the scientific method throughout the Program. Work with investigators to analyze data obtained in the studies being conducted and to assist in preparation of manuscripts, including description of the statistical approaches employed. Ensure that the statistical approaches employed in the overall program of research are state-of-the art and to introduce new strategies to address the scientificneeds ofthe program. 4. Provide to Core B optimal methodologyfor non-invasive behavioral screening coupled with outlier detection to facilitate i) exclusion of data from C5?BL/6NIA mice that exhibit non-normative sleep/wake behavior and 2) exclusion from analyses C57BL/6NIA mice that exhibit non-normative changes sleep/wake behavior after EEG/EMG implantation surgery to reduce residual variance when performing group and experimental condition comparisons involving project-specific primary and supporting outcome measures. Provide and maintain a multi-server storage, database, and web infrastructure and software applications to support research operation, data management, and data sharing. The system and accompanying software applications will have an emphasis on metadata and will adopt best data management practices ana data modelsfrom the industry and research community. This system will have a comprehensive database structure for (i) storing and sharing genotypic and phenotypic information for sleep/wake behavior across the lifespan in Drosophila and EEG/EMG, video, and other sleep/wake behavioral data in young, middle age,and old mice; (2) making the data directly accessible to researchers to ensure an integration of data, documentation of data, and research, operations and activities. These data will be made available by a web-enabled system to all investigators in the program. Selected data will be carefully characterized and made available to the larger scientific communitythrough the developmentofa new web-siteSomnoGenthat willserve as a resourcefor phenotypic and genotypic information concerning sleep in young and older animals.

该核心的总体目标是为联合国系统内的四个项目提供生物统计和数据库支持 方案项目，并向核心B的调查人员和工作人员：行为评估核心和促进 来自睡眠动物模型的遗传型和表型数据在幼年和 将年龄较大的动物转移到更大的科学界(数据共享)。为了实现这一目标，核心将做 以下内容： I.与研究人员合作，制定可靠的研究设计，澄清假设，确定样本量 将进行的实验，并促进统计思维和有效应用 科学的方法贯穿于整个计划。 与调查人员合作，分析正在进行的研究中获得的数据，并协助 手稿的准备，包括对所采用的统计方法的描述。 确保在整个研究计划中采用的统计方法是最先进的 并引入新的战略，以满足该计划的科学需求。 4.向核心B提供结合离群值的非侵入性行为筛查的最佳方法 检测以促进i)排除C5？BL/6NIA小鼠中表现出非标准的数据 睡眠/觉醒行为和2)分析显示非正常的C57BL/6NIA小鼠 改变EEG/EMG植入手术后的睡眠/觉醒行为以减少以下情况下的残余方差 进行小组和实验条件比较，包括项目特定的小学和 支持成果措施。 提供和维护多服务器存储、数据库以及Web基础架构和软件 支持研究运行、数据管理和数据共享的应用程序。该系统和 随附的软件应用程序将重点放在元数据上，并将采用最佳数据 来自行业和研究社区的管理实践和数据模型。这个系统将会 有一个全面的数据库结构，用于(I)存储和共享基因和表型 果蝇一生中睡眠/清醒行为的信息以及脑电/肌电、视频和 其他年轻、中年和老年小鼠的睡眠/清醒行为数据；(2)直接制作数据 研究人员可以访问，以确保数据、数据文档和研究的集成， 运营和活动。这些数据将由一个支持网络的系统提供给所有人 该项目中的调查人员。选定的数据将经过仔细的表征并提供给 更大的科学界，通过开发一个新的网站SomnoGen. 关于幼年和年长动物睡眠的表型和基因信息的资源。