Biostatistics and Bioinformatics Core

生物统计学和生物信息学核心的使命是保证所有参与研究的研究人员 项目可以获得与其特定研究目标相关的最先进的方法。的 通过该核心的相关教职员工可以获得丰富的经验和分析专业知识 该计划项目的主要资产，并为延续开发传统提供了一个平台 该项目的创新分析方法。该核心建立在上一个核心的成功核心之上 提交-生物统计和数据库核心。之前提交的核心教师。 格雷格·麦斯林（Greg Maislin）和亚伯拉罕·怀纳（Abraham Wyner）教授继续致力于提供领导稳定性。博士。 John Hogenesch 和 Ron Anafi 博士是新增加的核心教师，以满足不断发展的生物信息学需求 项目的需求。核心教职员工将确保在研究中采用的统计方法 总体计划是最先进的，并将继续酌情引入新的战略 协助满足该计划的科学需求。 Wyner 教授将继续支持应用 最先进的睡眠-觉醒行为数据机器学习分类算法，并开发新的 确定需求的方法。博士。 Hogenesch 和 Anafi 将促进尖端技术的应用 生物信息学策略并使计划研究人员能够利用新发现 整个计划的资助期间。麦斯林教授长达二十多年的合作 与项目总监合作，在将各种生物统计方法应用于睡眠方面拥有丰富的经验 和老龄化相关的研究问题有助于制定稳健的研究设计、明确的陈述 假设以及整个计划中科学方法的有效应用。教职员工 生物统计学和生物信息学核心将与研究人员合作分析研究中获得的数据 正在进行并协助准备手稿，包括统计数据的描述 采用的方法。该核心还将与小鼠行为评估和 育种核心（核心 B）应用统计方法来评估寿命变化 将根据生理生物标志物的相关变化来评估睡眠和觉醒行为 跨所有项目。生物统计学和生物信息学核心与所有三个紧密集成 项目和其他核心，并作为该计划的重要组成部分和主要资产 项目。

The mission of the Biostatistics and Bioinformatics Core is to guarantee that all investigators involved in the Program have access to state-of-the art methodology relevant to their specific research aims. The substantial experience and analytical expertise available through this Core's associated faculty and staff is a major asset to the Program Project and provides a platform for continuing the tradition of developing innovative analytical approaches to the Project. This Core builds on the successful core in the previous submission-the Biostatistical and Data Base Core. The Core faculty from the previous submission. Professors Greg Maislin and Abraham Wyner, continue to be involved providing stability in leadership. Dr. John Hogenesch and Dr. Ron Anafi are new Core faculty added in order to meet the evolving bioinformatics needs of the projects. The Core faculty and staff will ensure that the statistical approaches employed in the overall program are state of the art, and will continue to introduce, where appropriate, new strategies to assist in meeting the scientific needs of the Program. Professor Wyner will continue to support application of state-of-art machine learning classification algorithms of sleep-wake behavioral data and to develop new methodology as needs are identified. Drs. Hogenesch and Anafi will facilitate application of cutting edge bioinformatics strategies and will enable the Program investigators to take advantage of new discoveries throughout the funding period of the Program. Professor Maislin's more than two decade long collaboration with the Program Director and broad experience in applying a wide range of biostatistical methods to sleep and aging related research questions facilitates the development of robust study designs, clear statements of hypotheses, and the valid application of the scientific method throughout the Program. Faculty and staff of the Biostatistics and Bioinformatics Core will work with investigators to analyze data obtained in the studies being conducted and assist in the preparation of manuscripts, including description of the statistical approaches employed. The Core will also work closely with the Mouse Behavioral Assessment and Breeding Core (Core B) in the application of statistical methodology designed to assess lifespan changes in sleep and wake behavior that will be assessed relative to relevant changes in physiological biomarkers across all of the Projects. The Biostatistics and Bioinformatics Core is tightly integrated with the all three Projects and the other Cores and serves as an essential component and major asset of this Program Project.