Biostatistics and Bioinformatics Core

生物统计和生物信息学核心的使命是保证所有参与 项目可以接触到与其特定研究目标相关的最先进的方法。这个 通过该核心的相关教职员工提供的丰富经验和分析专业知识是 计划项目的主要资产，并提供了一个继续开发传统的平台 对该项目采取创新的分析方法。这一核心建立在上一次成功的核心之上 提交--生物统计和数据库核心。上一次提交的核心教职员工。 格雷格·梅斯林教授和亚伯拉罕·怀纳教授继续参与为领导层提供稳定。Dr。 John Hgenesch和Ron Anafi博士是为满足不断发展的生物信息学而增加的新核心教员 项目的需求。核心教员和工作人员将确保在 整个计划都是最先进的，并将在适当的情况下继续推出新的战略，以 协助满足该计划的科学需求。怀纳教授将继续支持 睡眠-觉醒行为数据的机器学习分类算法研究进展 已确定需要的方法。Hgenesch博士和Anafi博士将促进尖端技术的应用 生物信息学战略，并将使计划调查人员能够利用新的发现 在该计划的整个资助期内。梅斯林教授长达二十多年的合作 具有项目主任和在睡眠中应用各种生物统计学方法的丰富经验 与衰老相关的研究问题有助于制定稳健的研究设计，明确说明 假设，以及科学方法在整个计划中的有效应用。学院的教职员工 生物统计和生物信息学核心将与调查人员合作，分析研究中获得的数据 正在进行并协助编写手稿，包括统计数据的说明 所采用的方法。该中心还将与老鼠行为评估和 育种核心(核心B)应用旨在评估寿命变化的统计方法 睡眠和清醒行为将根据生理生物标记物的相关变化进行评估 在所有的项目中。生物统计和生物信息学核心与这三个核心紧密结合 项目和其他核心，并作为本计划的基本组成部分和主要资产 项目。

The mission of the Biostatistics and Bioinformatics Core is to guarantee that all investigators involved in the Program have access to state-of-the art methodology relevant to their specific research aims. The substantial experience and analytical expertise available through this Core's associated faculty and staff is a major asset to the Program Project and provides a platform for continuing the tradition of developing innovative analytical approaches to the Project. This Core builds on the successful core in the previous submission-the Biostatistical and Data Base Core. The Core faculty from the previous submission. Professors Greg Maislin and Abraham Wyner, continue to be involved providing stability in leadership. Dr. John Hogenesch and Dr. Ron Anafi are new Core faculty added in order to meet the evolving bioinformatics needs of the projects. The Core faculty and staff will ensure that the statistical approaches employed in the overall program are state of the art, and will continue to introduce, where appropriate, new strategies to assist in meeting the scientific needs of the Program. Professor Wyner will continue to support application of state-of-art machine learning classification algorithms of sleep-wake behavioral data and to develop new methodology as needs are identified. Drs. Hogenesch and Anafi will facilitate application of cutting edge bioinformatics strategies and will enable the Program investigators to take advantage of new discoveries throughout the funding period of the Program. Professor Maislin's more than two decade long collaboration with the Program Director and broad experience in applying a wide range of biostatistical methods to sleep and aging related research questions facilitates the development of robust study designs, clear statements of hypotheses, and the valid application of the scientific method throughout the Program. Faculty and staff of the Biostatistics and Bioinformatics Core will work with investigators to analyze data obtained in the studies being conducted and assist in the preparation of manuscripts, including description of the statistical approaches employed. The Core will also work closely with the Mouse Behavioral Assessment and Breeding Core (Core B) in the application of statistical methodology designed to assess lifespan changes in sleep and wake behavior that will be assessed relative to relevant changes in physiological biomarkers across all of the Projects. The Biostatistics and Bioinformatics Core is tightly integrated with the all three Projects and the other Cores and serves as an essential component and major asset of this Program Project.