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Particle engineering approaches to control the interaction of medicinal aerosols with the lung environment following inhalation

控制药用气溶胶吸入后与肺部环境相互作用的颗粒工程方法

基本信息

批准号：
2277525
负责人：
金额：
--
依托单位：
University of Hertfordshire
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2019
资助国家：
英国
起止时间：
2019 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=studentship-2277525
关键词：
Particle engineering approaches control interaction

项目摘要

Abstract: Aerosol therapeutics are widely used in the treatment of respiratory and systemic disease. As such, significant research has gone into how the active pharmaceutical ingredient and delivery device affect particle deposition and patient outcomes. However, there remains limited research on the dependency of water vapour interactions, in the respiratory system, on specific, physicochemical aerosol properties. Consequently, their influence on hygroscopic growth, dissolution and agglomeration within the lung environment is often overlooked. This project focuses on the delivery of solid drug particles by dry powder inhalers and reviews some of the particle properties that may underpin aerosol dynamics in the humidity of the respiratory system. Furthermore, in response, a novel way to produce monodisperse model particles with distinct characteristics and properties using microfluidic crystallisation techniques is presented. The subsequent investigation of the model particles will allow for the determination of the extent of impact that micromeritic properties, such as size, surface area and crystallinity, have on the interaction of solid drug particles with moisture in the human lung. In doing so, it will enhance the understanding of the fundamental, underlying principles of aerosol dynamics in the respiratory system and contribute to the potential for optimisation of aerosol drug delivery techniques.

【摘要】：气雾剂疗法广泛应用于呼吸系统疾病的治疗。因此，人们对活性药物成分和输送装置如何影响颗粒沉积和患者治疗结果进行了重要研究。然而，关于呼吸系统中水蒸气相互作用对特定物理化学气溶胶特性的依赖性的研究仍然有限。因此，它们对肺部环境中吸湿性生长、溶解和聚集的影响常常被忽视。该项目的重点是通过干粉吸入器输送固体药物颗粒，并审查可能支持呼吸系统湿度下气溶胶动力学的一些颗粒特性。此外，作为响应，提出了一种使用微流体结晶技术生产具有独特特征和性质的单分散模型颗粒的新方法。对模型颗粒的后续研究将有助于确定微米特性（例如尺寸、表面积和结晶度）对固体药物颗粒与人肺中水分相互作用的影响程度。这样做将增强对呼吸系统气溶胶动力学基本原理的理解，并有助于优化气溶胶药物输送技术的潜力。