In-situ studies of biomolecular assisted Li-air batteries and studies of biobased redox mediators and ORR catalysts
生物分子辅助锂空气电池的原位研究以及生物基氧化还原介质和ORR催化剂的研究
基本信息
- 批准号:2279750
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:英国
- 项目类别:Studentship
- 财政年份:2019
- 资助国家:英国
- 起止时间:2019 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
PhD project strategic theme: Bioscience for renewable resources and clean growthLi-air batteries (LABs) have gained significant attention lately due to their comparable energy densities to fossil fuels, with the added advantage of being greener than Lithium-ion batteries, as they contain no transition metals. Typical non-aqueous LABs rely on an oxygen reduction reaction (ORR) to discharge. Redox mediators (RMs) are often used to assist in the electron transfer between the cathode surface and O2, lowering the battery overpotential and controlling the rate of formation of the discharge products. Redox-active biomolecules, which play vital roles in energy assimilating processes in nature and often bind to enzymes as cofactors, are often used as RM in LABs. For instance, Quinones, such as DBBQ, Vitamin K2 or Enzyme Q10 have been tested as RMs with varying success. ORR biocatalysts, such as heme (haemoglobin's co-factor), and enzymes, such as laccase from Tramtes versicolor (LacTv), can be used to further increase the energy efficiency in LABs by providing stable intermediates to the formation/decomposition of the discharge product. The activity of biological ORR catalysts depends on the media where the reaction takes place, which affects their ability to solvate oxygen and binding energetics. This is particularly important since LABS operate in organic-based electrolytes, in contrast to the aqueous solutions of biological systems. The rate and properties of discharge product will be influenced by the pH and electron transfer rate in the cell, which in turn depends on the electrolyte, rate and type of catalyst/RM used.Currently, mechanistic studies of the activity of bio-based RM/ORR catalysts in battery set-ups is very limited. In order to establish a structure-function relationship that would help the development of biomolecular-assisted LABs, novel in-situ characterization techniques are required. The aim of this project is to develop in-situ X-ray Diffraction and Nuclear Magnetic Resonance Spectroscopies with which a comprehensive catalogue of biomolecular ORR catalysts can be studied. With these novel tools, we aim to develop optimized LABs based on sustainably sourced biomolecules by screening a library of potential ORR catalysts and RMs such as porphyrins, flavins, phenazines, phthalocyanins and enzymes to which these co-factors are bonded such as cytochrome c oxidase (CcO), monodehydroascorbate reductase (MDAR) or NADH oxidase. The differences of oxygen binding characteristics between soluble co-factors and enzymes grafted onto the electrodes in the battery setup and the effect to the overall performance will also be studied. These will allow us to study important properties regulating the activity of redox mediators, such as diffusivity, equilibrium redox potential, state of charge, and degradation pathways during battery operation. Studying redox active biomolecules with catalytic functions opens up a new path high performance RMs and ORR catalysts made of sustainable, cost-effective materials such as recyclable bio-waste (e.g. blood waste or natural enzymes). Both of these aspects tie in well with the BBSRC strategic theme Bioscience for renewable resources and clean growth, which aims to transform a range of industries by reducing the reliance on fossil fuels and thereby help to meet international climate change targets.
博士项目战略主题:可再生资源和清洁增长的生物科学锂空气电池(LAB)最近受到了极大的关注,因为它们的能量密度与化石燃料相当,而且由于不含过渡金属,因此比锂离子电池更环保。典型的非水LAB依赖于氧还原反应(ORR)来放电。氧化还原介体(RM)通常用于辅助阴极表面和O2之间的电子转移,降低电池过电位并控制放电产物的形成速率。氧化还原活性生物分子在自然界的能量同化过程中发挥着至关重要的作用,并且通常与作为辅因子的酶结合,通常用作LAB中的RM。例如,醌,如DBBQ,维生素K2或酶Q10已被测试为RM,并取得了不同的成功。ORR生物催化剂,如血红素(血红蛋白的辅因子)和酶,如来自杂色栓菌(Tramtes versicolor)的漆酶(LacTv),可用于通过提供稳定的中间体以形成/分解放电产物来进一步提高LAB中的能量效率。生物ORR催化剂的活性取决于反应发生的介质,这影响它们溶解氧和结合能的能力。这是特别重要的,因为LABS在有机基电解质中运行,与生物系统的水溶液相反。电池中的pH值和电子转移速率会影响放电产物的速率和性质,而这又取决于所使用的电解质、速率和催化剂/RM的类型。为了建立一个结构与功能的关系,这将有助于生物分子辅助LAB的发展,需要新的原位表征技术。该项目的目的是开发原位X射线衍射和核磁共振光谱,从而可以研究生物分子ORR催化剂的全面目录。利用这些新的工具,我们的目标是通过筛选潜在的ORR催化剂和RM(如卟啉、黄素、吩嗪、酞菁和这些辅因子所结合的酶,如细胞色素c氧化酶(CcO)、单脱氢抗坏血酸还原酶(MDAR)或NADH氧化酶)的文库,开发基于可持续来源的生物分子的优化的LAB。此外,还将研究可溶性辅因子和接枝到电池设置中的电极上的酶之间的氧结合特性的差异以及对整体性能的影响。这些将使我们能够研究调节氧化还原介质活性的重要特性,例如扩散率,平衡氧化还原电位,充电状态和电池运行期间的降解途径。研究具有催化功能的氧化还原活性生物分子开辟了一条新的途径,即由可持续的、具有成本效益的材料制成的高性能RM和ORR催化剂,如可回收的生物废物(例如血液废物或天然酶)。这两个方面都与BBSRC的战略主题“生物科学促进可再生资源和清洁增长”密切相关,该主题旨在通过减少对化石燃料的依赖来改变一系列行业,从而帮助实现国际气候变化目标。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
其他文献
吉治仁志 他: "トランスジェニックマウスによるTIMP-1の線維化促進機序"最新医学. 55. 1781-1787 (2000)
Hitoshi Yoshiji 等:“转基因小鼠中 TIMP-1 的促纤维化机制”现代医学 55. 1781-1787 (2000)。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
LiDAR Implementations for Autonomous Vehicle Applications
- DOI:
- 发表时间:
2021 - 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
吉治仁志 他: "イラスト医学&サイエンスシリーズ血管の分子医学"羊土社(渋谷正史編). 125 (2000)
Hitoshi Yoshiji 等人:“血管医学与科学系列分子医学图解”Yodosha(涉谷正志编辑)125(2000)。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Effect of manidipine hydrochloride,a calcium antagonist,on isoproterenol-induced left ventricular hypertrophy: "Yoshiyama,M.,Takeuchi,K.,Kim,S.,Hanatani,A.,Omura,T.,Toda,I.,Akioka,K.,Teragaki,M.,Iwao,H.and Yoshikawa,J." Jpn Circ J. 62(1). 47-52 (1998)
钙拮抗剂盐酸马尼地平对异丙肾上腺素引起的左心室肥厚的影响:“Yoshiyama,M.,Takeuchi,K.,Kim,S.,Hanatani,A.,Omura,T.,Toda,I.,Akioka,
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('', 18)}}的其他基金
An implantable biosensor microsystem for real-time measurement of circulating biomarkers
用于实时测量循环生物标志物的植入式生物传感器微系统
- 批准号:
2901954 - 财政年份:2028
- 资助金额:
-- - 项目类别:
Studentship
Exploiting the polysaccharide breakdown capacity of the human gut microbiome to develop environmentally sustainable dishwashing solutions
利用人类肠道微生物群的多糖分解能力来开发环境可持续的洗碗解决方案
- 批准号:
2896097 - 财政年份:2027
- 资助金额:
-- - 项目类别:
Studentship
A Robot that Swims Through Granular Materials
可以在颗粒材料中游动的机器人
- 批准号:
2780268 - 财政年份:2027
- 资助金额:
-- - 项目类别:
Studentship
Likelihood and impact of severe space weather events on the resilience of nuclear power and safeguards monitoring.
严重空间天气事件对核电和保障监督的恢复力的可能性和影响。
- 批准号:
2908918 - 财政年份:2027
- 资助金额:
-- - 项目类别:
Studentship
Proton, alpha and gamma irradiation assisted stress corrosion cracking: understanding the fuel-stainless steel interface
质子、α 和 γ 辐照辅助应力腐蚀开裂:了解燃料-不锈钢界面
- 批准号:
2908693 - 财政年份:2027
- 资助金额:
-- - 项目类别:
Studentship
Field Assisted Sintering of Nuclear Fuel Simulants
核燃料模拟物的现场辅助烧结
- 批准号:
2908917 - 财政年份:2027
- 资助金额:
-- - 项目类别:
Studentship
Assessment of new fatigue capable titanium alloys for aerospace applications
评估用于航空航天应用的新型抗疲劳钛合金
- 批准号:
2879438 - 财政年份:2027
- 资助金额:
-- - 项目类别:
Studentship
Developing a 3D printed skin model using a Dextran - Collagen hydrogel to analyse the cellular and epigenetic effects of interleukin-17 inhibitors in
使用右旋糖酐-胶原蛋白水凝胶开发 3D 打印皮肤模型,以分析白细胞介素 17 抑制剂的细胞和表观遗传效应
- 批准号:
2890513 - 财政年份:2027
- 资助金额:
-- - 项目类别:
Studentship
Understanding the interplay between the gut microbiome, behavior and urbanisation in wild birds
了解野生鸟类肠道微生物组、行为和城市化之间的相互作用
- 批准号:
2876993 - 财政年份:2027
- 资助金额:
-- - 项目类别:
Studentship
相似国自然基金
脂滴聚集型小胶质细胞介导的髓鞘病变促进小鼠抑郁样行为及其机制研究
- 批准号:82371528
- 批准年份:2023
- 资助金额:49.00 万元
- 项目类别:面上项目
星形胶质细胞介导的髓鞘吞噬参与慢性脑低灌注白质损伤的机制研究
- 批准号:82371307
- 批准年份:2023
- 资助金额:49.00 万元
- 项目类别:面上项目
相似海外基金
Center for Developmental Mapping of Heart and Bone Tissues
心脏和骨组织发育图谱中心
- 批准号:
10251350 - 财政年份:2020
- 资助金额:
-- - 项目类别:
Center for Developmental Mapping of Heart and Bone Tissues
心脏和骨组织发育图谱中心
- 批准号:
10118850 - 财政年份:2020
- 资助金额:
-- - 项目类别:
3D Cellular and Molecular Mapping within Skeletal Tissue
骨骼组织内的 3D 细胞和分子图谱
- 批准号:
10355748 - 财政年份:2020
- 资助金额:
-- - 项目类别:
BIOMOLECULAR STUDIES OF UNIQUE RETINAL SPECIFIC PROTEINS
独特的视网膜特异性蛋白质的生物分子研究
- 批准号:
3262056 - 财政年份:1986
- 资助金额:
-- - 项目类别:
BIOMOLECULAR STUDIES OF UNIQUE RETINAL SPECIFIC PROTEINS
独特的视网膜特异性蛋白质的生物分子研究
- 批准号:
3262050 - 财政年份:1986
- 资助金额:
-- - 项目类别:
BIOMOLECULAR STUDIES OF UNIQUE RETINAL SPECIFIC PROTEINS
独特的视网膜特异性蛋白质的生物分子研究
- 批准号:
2159749 - 财政年份:1986
- 资助金额:
-- - 项目类别: