CORE--FAMILY ASCERTAINMENT AND GENETIC TESTING

遗传易感性测试核心的核心作用是提供 BRCA 1突变检测的资源，以开发和维护杜克 家族性乳腺癌数据库（FBCD），并开发和维护DNA 杜克乳腺癌孢子内的银行。这将提供一个资源， 杜克大学医学院的遗传流行病学和分子研究 中心这一努力的总体目标是推进我们的基本和 乳腺癌易感基因BRCA 1的临床认识。 这一目标是通过提供关键人员组装乳房 癌症家族数据，收集血液样本进行分子分析， 对DNA进行测序以确定BRCA 1突变的存在。遗传 药敏试验核心将直接与Drs.Winer和 里默的研究，并将提供资源，以确定亲属从 家族性乳腺癌-卵巢癌遗传易感性 Testing Core还将为Dr. Mark和Berchuck对细胞的分子生物学和功能的研究， BRCA 1基因。 数据将被生成，以促进博士。 Prosnitz在开发决策模型方面的努力。所有统计分析 将由生物统计学和数据管理核心进行。的 遗传易感性测试核心不仅将提供资源， 各种与SPORE相关的项目，但将是未来的跳板 家族性乳腺癌的遗传流行病学和分子研究。我们 还将与史蒂文·纳罗德博士合作， 北美乳腺癌联盟的活动。

The central role of the Genetic Susceptibility Testing Core is to provide a resource for BRCA1 mutation testing, to develop and maintain the Duke Familial Breast Cancer Database (FBCD), and develop and maintain a DNA bank within the Duke Breast Cancer SPORE. This will provide a resource for genetic epidemiologic and molecular studies at Duke University Medical Center. The overall goal of this effort is to advance our basic and clinical understanding of the BRCA1 susceptibility gene for breast cancer. This goal is accomplished by providing key personnel to assemble breast cancer family data, to collect blood samples for molecular analyses, and to sequence DNA to determine the presence of BRCA1 mutations. The Genetic Susceptibility Testing Core will directly interface with Drs.Winer's and Rimer's study and will provide the resource to identify relatives from familial breast-ovarian cancer families. The Genetic Susceptibility Testing Core will also provide BRCA1 sequencing capabilities for Drs. Mark's and Berchuck's study of the molecular biology and function of the BRCA1 gene. Data will be generated to facilitate Drs. Berry's and Prosnitz's effort in developing decision models. All statistical analyses will be performed by the Biostatistics and Data Management Core. The Genetic Susceptibility Testing Core will not only provide a resource for the various SPORE-related projects but will be a spring-board for future genetic epidemiologic and molecular studies of familial breast cancer. We will also collaborate with Dr. Steven Narod and participate in the activities of the North American Breast Cancer Consortium.