Integrating Population and Basic Science in Cancer Research

将人口和基础科学整合到癌症研究中

• 批准号: 8535616
• 负责人: Joellen M. SCHILDKRAUT
• 金额: $ 27.27万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8535616
• 关键词: Address; Advertising; Advisory Committees; Affect; Aging; Animals; Applications Grants; Area; Basic Science; Biological Markers; Biometry; Cancer Biology; Cancer Science; Collaborations; Committee Members; Comparative Carcinogenesis; Complex; Data; Data Sources; Demography; Detection; Development; Discipline; Disease; Duke Comprehensive Cancer Center; Education; Environment; Epidemiology; Epigenetic Process; Experimental Designs; Faculty; Genetic; Health behavior; Human; Incidence; Information Networks; Interdisciplinary Study; Interview; Journals; Knowledge; Laboratory Animals; Link; Malignant Neoplasms; Mentors; Molecular Genetics; Motivation; Online Systems; Pharmacogenetics; Population; Population Genetics; Population Sciences; Population Study; Postdoctoral Fellow; Prevention; PubMed; Publications; Qualifying; Recruitment Activity; Research; Research Methodology; Research Personnel; Research Project Grants; Research Training; Resources; Risk Factors; Sample Size; Science; Scientist; Solid; Source; Statistical Methods; Statistical Models; Survival Analysis; Training; Training Program for Cancer Prevention and Control Scientists (R25); Training Programs; Universities; anticancer research; base; cancer epidemiology; cancer genetics; cancer initiation; cancer prevention; cancer risk; career; career development; design; experience; genetic epidemiology; improved; interdisciplinary approach; mathematical model; multidisciplinary; preference; programs; research study; skills; statistics

DESCRIPTION (provided by applicant): The purpose of this Cancer Education and Career Development Program (CECDP) is preparing junior and more experienced basic scientists for the interdisciplinary research environment. The CECDP is primarily designed for experimental cancer researchers to obtain training in population science including cancer epidemiology, survival analysis, population genetics, pharmacogenetics, and statistical modeling of cancer. An important feature of the proposed program is that it focuses on integrating knowledge from population and experimental studies of cancer and establishes links between these different areas in both educational and scientific parts of the program. Such interdisciplinary focus is lacking in existing cancer training programs. It aims to improve credibility of studies performed by experimental cancer researchers. The program will include: (l) six semesters of weekly seminars (conducted by both faculty and trainees) emphasizing connections between cancer biology and epidemiology; human and animal studies of cancer; cancer and aging; population genetics and epigenetics; cancer biomarkers and prevention; and statistical approaches to population and experimental studies of cancer; (2) research training and project in population science; (3) preparing scientific publications and mock grant application with the interdisciplinary focus, for further career development. The program will be based at the Duke Comprehensive Cancer Center's Research Program in Cancer Prevention, Detection, and Control, and will engage faculty, mentors, and Advisory Committee members from various Duke Departments, representing all the areas involved into this program. We plan to recruit four fellows who have completed doctorates in basic/experimental cancer biology/genetics. Recruitment will be undertaken on a national level, followed by personal interviews to identify postdoctoral candidates with strong motivation in interdisciplinary cancer research. Our multidisciplinary team of highly qualified faculty/mentors is capable to carry out both educational and research parts of this program. With support of comprehensive scientific resources of Duke University, this will provide a solid environment for the interdisciplinary training and career development proposed in the CECDP.

描述(由申请人提供)：该癌症教育和职业发展计划(CECDP)的目的是为跨学科研究环境培养初级和更有经验的基础科学家。CECDP主要是为实验癌症研究人员设计的，以获得人口科学方面的培训，包括癌症流行病学、生存分析、人口遗传学、药物遗传学和癌症统计建模。拟议计划的一个重要特点是，它侧重于整合来自人口和癌症实验研究的知识，并在该计划的教育和科学部分建立这些不同领域之间的联系。在现有的癌症培训计划中，缺乏这种跨学科的重点。它的目的是提高实验性癌症研究人员进行的研究的可信度。该计划将包括：(L)为期六个学期的每周研讨会(由教师和实习生共同主持)，强调癌症生物学和流行病学之间的联系；人类和动物癌症研究；癌症与衰老；人口遗传学和表观遗传学；癌症生物标志物和预防；以及人口统计方法和癌症实验研究；(2)人口科学研究培训和项目；(3)准备跨学科重点的科学出版物和模拟拨款申请，以促进进一步的职业发展。该计划将以杜克综合癌症中心癌症预防、检测和控制研究计划为基础，并将聘请来自杜克大学不同部门的教师、导师和咨询委员会成员，代表该计划涉及的所有领域。我们计划招聘四名已完成基础/实验癌症生物学/遗传学博士学位的研究员。招聘将在国家层面上进行，随后将进行个人面试，以确定在跨学科癌症研究方面具有强烈动机的博士后候选人。我们由高素质的教师/导师组成的多学科团队有能力执行该项目的教育和研究部分。在杜克大学综合科学资源的支持下，这将为CECDP提出的跨学科培训和职业发展提供坚实的环境。

项目成果

Genomic profiling in locally advanced and inflammatory breast cancer and its link to DCE-MRI and overall survival.

• DOI: 10.3109/02656736.2015.1016557
• 发表时间: 2015-06
• 期刊: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
• 作者: Siamakpour-Reihani S;Owzar K;Jiang C;Scarbrough PM;Craciunescu OI;Horton JK;Dressman HK;Blackwell KL;Dewhirst MW
• 通讯作者: Dewhirst MW

What can we learn from the age- and race/ethnicity- specific rates of inflammatory breast carcinoma?

我们可以从特定年龄和种族/民族的炎性乳腺癌发病率中了解到什么？

• DOI: 10.1007/s10549-011-1719-4
• 发表时间: 2011
• 期刊: Breast cancer research and treatment
• 影响因子: 3.8
• 作者: Il'yasova,Dora;Siamakpour-Reihani,Sharareh;Akushevich,Igor;Akushevich,Lucy;Spector,Neil;Schildkraut,Joellen
• 通讯作者: Schildkraut,Joellen