Integrating Population and Basic Science in Cancer Research

将人口和基础科学整合到癌症研究中

• 批准号: 8138005
• 负责人: Joellen M. SCHILDKRAUT
• 金额: $ 48.26万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8138005
• 关键词: Address; Advertising; Advisory Committees; Affect; Aging; Animals; Applications Grants; Area; Basic Science; Biological Markers; Biometry; Cancer Biology; Cancer Science; Collaborations; Committee Members; Comparative Carcinogenesis; Complex; Data; Data Sources; Demography; Detection; Development; Discipline; Disease; Duke Comprehensive Cancer Center; Education; Environment; Epidemiology; Epigenetic Process; Experimental Designs; Faculty; Genetic; Health behavior; Human; Incidence; Information Networks; Interdisciplinary Study; Interview; Journals; Knowledge; Laboratory Animals; Link; Malignant Neoplasms; Mentors; Molecular Genetics; Motivation; Online Systems; Pharmacogenetics; Population; Population Genetics; Population Sciences; Population Study; Postdoctoral Fellow; Prevention; PubMed; Publications; Qualifying; Recruitment Activity; Research; Research Methodology; Research Personnel; Research Project Grants; Research Training; Resources; Risk Factors; Sample Size; Science; Scientist; Solid; Source; Statistical Methods; Statistical Models; Survival Analysis; Training; Training Program for Cancer Prevention and Control Scientists (R25); Training Programs; Universities; anticancer research; base; cancer epidemiology; cancer genetics; cancer initiation; cancer prevention; cancer risk; career; career development; design; experience; genetic epidemiology; improved; interdisciplinary approach; mathematical model; multidisciplinary; preference; programs; research study; skills; statistics

DESCRIPTION (provided by applicant): The purpose of this Cancer Education and Career Development Program (CECDP) is preparing junior and more experienced basic scientists for the interdisciplinary research environment. The CECDP is primarily designed for experimental cancer researchers to obtain training in population science including cancer epidemiology, survival analysis, population genetics, pharmacogenetics, and statistical modeling of cancer. An important feature of the proposed program is that it focuses on integrating knowledge from population and experimental studies of cancer and establishes links between these different areas in both educational and scientific parts of the program. Such interdisciplinary focus is lacking in existing cancer training programs. It aims to improve credibility of studies performed by experimental cancer researchers. The program will include: (l) six semesters of weekly seminars (conducted by both faculty and trainees) emphasizing connections between cancer biology and epidemiology; human and animal studies of cancer; cancer and aging; population genetics and epigenetics; cancer biomarkers and prevention; and statistical approaches to population and experimental studies of cancer; (2) research training and project in population science; (3) preparing scientific publications and mock grant application with the interdisciplinary focus, for further career development. The program will be based at the Duke Comprehensive Cancer Center's Research Program in Cancer Prevention, Detection, and Control, and will engage faculty, mentors, and Advisory Committee members from various Duke Departments, representing all the areas involved into this program. We plan to recruit four fellows who have completed doctorates in basic/experimental cancer biology/genetics. Recruitment will be undertaken on a national level, followed by personal interviews to identify postdoctoral candidates with strong motivation in interdisciplinary cancer research. Our multidisciplinary team of highly qualified faculty/mentors is capable to carry out both educational and research parts of this program. With support of comprehensive scientific resources of Duke University, this will provide a solid environment for the interdisciplinary training and career development proposed in the CECDP.

描述（由申请人提供）：该癌症教育和职业发展计划（CECDP）的目的是为跨学科研究环境培养初级和更有经验的基础科学家。CECDP主要是为实验癌症研究人员设计的，以获得人口科学方面的培训，包括癌症流行病学，生存分析，群体遗传学，药物遗传学和癌症统计建模。拟议计划的一个重要特征是，它侧重于整合癌症人口和实验研究的知识，并在计划的教育和科学部分中建立这些不同领域之间的联系。这种跨学科的重点是缺乏现有的癌症培训计划。它旨在提高实验癌症研究人员进行的研究的可信度。该方案将包括：（l）六个学期的每周研讨会（由教职员及学员共同主持）着重癌症生物学与流行病学、癌症的人类及动物研究、癌症与老化、人口遗传学与表观遗传学、癌症生物标记与预防、人口统计方法与癌症实验研究之间的联系;（2）人口科学的研究训练及计划;（3）准备科学出版物和模拟资助申请，以跨学科为重点，以进一步发展职业生涯。该计划将以杜克综合癌症中心的癌症预防、检测和控制研究计划为基础，并将吸引来自各杜克部门的教师、导师和咨询委员会成员，代表参与该计划的所有领域。我们计划招募四名已完成基础/实验癌症生物学/遗传学博士学位的研究员。招聘将在国家一级进行，然后进行个人面试，以确定在跨学科癌症研究中具有强烈动机的博士后候选人。我们的高素质教师/导师的多学科团队能够开展该计划的教育和研究部分。在杜克大学综合科学资源的支持下，这将为CECDP中提出的跨学科培训和职业发展提供坚实的环境。