Supplement to RR15577-Mentoring Immunology in Oklahoma:

描述（由申请人提供）： 该提案是对受资助的COBRE P20 RR 15577“俄克拉荷马州免疫学指导”的补充。俄克拉荷马州医学研究基金会（OMRF）寻求资金，用于COBRE研究人员的新程序工作区和生物防护研究区的3000平方英尺空间的翻新。《实验动物护理和使用指南》建议为实验程序提供专门的实验室或与动物设施相邻的空间。目前的程序空间不足200平方英尺，已经过时。COBRE调查人员经常由于时间安排冲突或空间限制而延迟工作，许多人被迫将动物从设施中取出进行实验程序，然后将其送回，在某些情况下，项目必须取消或在其他机构进行。OMRF已确定这是一个关键的需求，并已将这种类型的空间纳入其长期资本项目规划。所要求的翻修不仅将纠正所述缺陷，而且将为COBRE调查员和OMRF带来新的和急需的专门知识领域。一个新的程序领域，包括空间的冷冻切片机和激光解剖显微镜将大大提高COBRE成像和微阵列核心，并增加新的和令人兴奋的研究能力。生物防护空间的增加，目前在俄克拉荷马州还没有，将以一种主要的方式增强COBRE赠款的所有项目;信号核心，显微注射核心加上对来自俄克拉荷马州大学和俄克拉荷马州州立大学的COBRE研究人员的合作具有巨大的区域重要性。OMRF已承诺投入大量资源用于资本改善，以便在PHS资助的研究赠款方面更具竞争力，但需要继续提供研究基础设施，以便继续取得有意义的进展。

DESCRIPTION (provided by applicant): This proposal is a supplement to the funded COBRE P20 RR15577 "Mentoring Immunology in Oklahoma". The Oklahoma Medical Research Foundation (OMRF) seeks funding for the renovation of 3000 ft 2 of space for new procedural work areas and biocontainment research areas for the COBRE investigators. The Guide for the Care and Use of Laboratory Animals recommends that specialized laboratories or space contiguous with animal facilities be provided for experimental procedures. The current procedural space consists of less than 200 ft 2 and is antiquated. COBRE investigators often have their work delayed due to scheduling Conflicts or space limitations, many are forced to remove the animals from the facility for experimental procedures then return them and in some instances projects must be cancelled or conducted at other institutions. OMRF has identified this as a critical need and has included this type of space into its long range capital project planning. The requested renovation would not only correct the stated deficiency but would bring new and much needed areas of expertise to the COBRE investigators and OMRF. A novel procedural area that incorporates space for a cryomicrotome and a laser dissection microscope would greatly enhance the COBRE imaging and microarray cores and add new and exciting research capability. The addition of biocontainment space, currently not available in Oklahoma, would enhance all the projects of the COBRE grant in a major way; the signaling core, the microinjection core plus be of tremendous regional importance to the collaboration of COBRE investigators from the University of Oklahoma and Oklahoma State University. OMRF has committed significant resources to capital improvement in order to be more competitive for PHS funded research grants but needs to continue to provide research infrastructure in order to continue to make meaningful progress.