OK COBRE: RECRUITING CORE

OK COBRE：招募核心人员

• 批准号: 7171336
• 负责人: J Donald Capra
• 金额: $ 2.14万
• 依托单位: OKLAHOMA MEDICAL RESEARCH FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7171336
• 关键词: autoimmunity; clinical research; disease /disorder etiology; genetic susceptibility; human subject; immunogenetics; patient oriented research; systemic lupus erythematosus

DESCRIPTION (provided by applicant):The Oklahoma Medical Research Foundation (OMRF) herein proposes a site for a Center for Biomedical Research Excellence (COBRE) on "Molecular Mechanisms and Genetics of Autoimmunity." Research programs in immunology and rheumatic diseases were initiated over 20 years ago at the OMRF and have been steadily growing since. The faculty is responsible for a number of seminal discoveries and has made this an area of research excellence at the OMRF upon which to build this COBRE. We propose four Junior Investigators who have promising futures for biomedical research productivity in the genetics and molecular mechanisms of autoimmunity. Indeed, their projects should have an important impact upon our understanding of important autoimmune disease problems. These Junior Investigators are supported by eight exceptional Mentors, who will provide the guidance and advocacy so important for launching the successful careers of independent scientists. The projects proposed by the Junior Investigators will also be facilitated by a Nucleic Acid Analysis Core and a Data Analysis Core, both of which are directed by very experienced and knowledgeable staff scientists. Indeed, these cores will help efficiently and economically apply the most sophisticated technologies and methods to the problems being addressed in the projects performed by the Junior Investigators. Additional COBRE Junior Investigators will be recruited to this center making this a transitional mechanism for the development of many independent investigators, thereby sustaining the level of excellence now achieved in research into autoimmunity in Oklahoma. The synergies, collaborations, and directed effort of the COBRE will provide a much deeper level of understanding to human autoimmune diseases and will foster the independent career development of a strong group of Junior Investigators.

描述（由申请人提供）：俄克拉荷马州医学研究基金会（OMRF）此处提出了一个关于卓越生物医学研究中心（COBRE）的地点，涉及“自身免疫的分子机制和遗传学”。免疫学和风湿性疾病的研究计划是20年前在OMRF启动的，此后一直在稳步增长。该教师负责许多开创性的发现，并使这一领域成为了建立该鞋底的OMRF的卓越研究领域。我们提出了四名初级研究人员，他们在自身免疫性的遗传学和分子机制中具有生物医学研究生产力有希望的未来。确实，他们的项目应该对我们对重要自身免疫性疾病问题的理解产生重要影响。这些初级调查人员得到了八位杰出导师的支持，他们将提供对启动独立科学家成功职业至关重要的指导和倡导。初级研究人员提出的项目还将通过核酸分析核心和数据分析核心促进，这两者都是由经验丰富且知识渊博的员工科学家指导的。的确，这些核心将有助于有效，经济上将最复杂的技术和方法应用于初级研究人员执行的项目中所解决的问题。将招募其他柯布尔初级调查人员到该中心，这是为许多独立研究人员发展的过渡机制，从而维持目前在俄克拉荷马州自动免疫研究中所取得的卓越水平。 COBRE的协同作用，合作和指示努力将为人类自身免疫性疾病提供更深刻的了解，并将促进一群强大的初级调查人员的独立职业发展。