Internat. Meeting on Epithelial-Mesenchymal Transitions

国际。

• 批准号: 6704996
• 负责人: ELIZABETH D HAY
• 金额: $ 2.4万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-22 至 2004-08-21
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6704996
• 关键词: embryology; epithelium; meeting /conference /symposium; mesenchyme; metastasis; pathologic process; travel

DESCRIPTION (provided by applicant): Epithelio-Mesenchymal Transition (EMT) has been long recognized as an essential, highly regulated, and often employed mechanism in embryological development, used whenever epithelial cells need to translocate. Many eminent embryologists work in this well-established area. Early indications over the past 2 decades that EMT may also play an important role in carcinoma metastasis have recently matured, with high-level reports documenting the progression-like consequences of EMT in various cancer systems. This has heralded a growing acceptance of EMT in the cancer field, overcoming initial skepticism. Similarly, the role of EMT in other pathologies, including renal fibrosis and cataracts, is becoming clear. However, much is still to be learned about the regulation, roles, and critical targetable features of EMT. Many of the approaches developed and refined for carcinoma research can also be well-utilized by developmental biologists and pathologists in their EMT studies, and vice versa. In particular, acknowledgment of the critical role of microenvironmental cues in regulating both carcinoma and developmental EMT pave the way for the prioritization of studies in this area. Facilitated interaction between developmental and cancer biologists and pathologists is essential to maximize the impact and benefit of the combined wisdom accumulated in these domains. The proposed meeting is groundbreaking in that it aims to do just that. An outstanding International Organizing Committee has been recruited for this timely meeting, an attractive and isolated venue has been chosen, dates set, and sponsorship requests initiated. Karger, who published 2 issues of Acta Anat. on this topic several years ago, has agreed to publish the proceedings. The meeting will feature 3 solid days of symposia, an afternoon devoted to roundtable discussion group, and two other integration sessions. Gender balance has been prioritized and largely achieved, and a number of talks will be selected from submitted abstracts where emphasis again will be placed on women and minorities. Our goal is for this conference to bring together a diverse international group of academic and industrial scientists with interests ranging from basic molecular, cellular and physiological mechanisms of EMT action, to physician-scientists interested in EMTs as therapeutic targets. The relatively small size, focused Scientific Sessions, and continuous Poster Session combine to provide an exciting forum for the exchange of ideas and to provide extensive opportunities for participation by a diverse group of scientists interested in EMTs in cancer, development, and a host of pathologies. We request NIH support primarily for travel for emerging USA scientists in this area, and to support the travel of two more senior, distinguished US speakers to ensure that the most relevant and up-to-date information is featured at this pivotal and highly influential meeting.

描述(由申请人提供)：长期以来，上皮-间充质转化(EMT)一直被认为是胚胎发育中一种基本的、高度调控的、经常使用的机制，用于上皮细胞需要移位的时候。许多杰出的胚胎学家都在这个久负盛名的领域工作。在过去的20年里，EMT在癌症转移中也可能扮演重要角色的早期迹象最近已经成熟，高水平的报告记录了EMT在各种癌症系统中的进展样后果。这预示着EMT在癌症领域的接受度越来越高，克服了最初的怀疑。同样，EMT在包括肾纤维化和白内障在内的其他病理中的作用也变得越来越清楚。然而，关于EMT的规则、作用和关键的靶向特征仍有许多需要了解。许多为癌症研究开发和改进的方法也可以被发育生物学家和病理学家在EMT研究中很好地利用，反之亦然。特别是，对微环境信号在调节癌症和发育性EMT中的关键作用的认识，为这一领域研究的优先次序铺平了道路。促进发育和癌症生物学家和病理学家之间的互动对于最大限度地发挥在这些领域积累的综合智慧的影响和好处至关重要。拟议中的会议具有开创性，因为它的目标就是做到这一点。为这次及时的会议招募了一个出色的国际组织委员会，选择了一个吸引人的和与世隔绝的地点，确定了日期，并提出了赞助请求。卡格尔出版了两期《阿纳特学报》。关于这个话题，几年前就已经同意发表论文集。会议将包括为期三天的专题讨论会，一个下午专门讨论圆桌讨论小组，以及另外两个整合会议。性别平衡已列为优先事项，并在很大程度上实现了这一点，将从提交的摘要中挑选一些讲座，其中将再次强调妇女和少数群体。我们的目标是将不同的国际学术和工业科学家小组聚集在一起，他们的兴趣范围从EMT作用的基本分子、细胞和生理机制，到对EMT作为治疗目标感兴趣的内科科学家。规模相对较小、重点突出的科学会议和连续的海报会议相结合，为思想交流提供了一个令人兴奋的论坛，并为对EMT感兴趣的不同科学家群体提供了广泛的参与机会，这些科学家对癌症、发展和一系列病理学感兴趣。我们请求美国国立卫生研究院主要为这一领域的新兴美国科学家的旅行提供支持，并支持另外两名资深、杰出的美国演讲者的旅行，以确保在这一关键和极具影响力的会议上展示最相关和最新的信息。