Conference--Molecular & Cellular Bioenergetics

会议--分子

• 批准号: 6597174
• 负责人: MICHAEL D FORGAC
• 金额: $ 0.6万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-01 至 2004-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6597174
• 关键词: bioenergetics; cell biology; electron transport; meeting /conference /symposium; molecular biology; oxidative phosphorylation; travel

DESCRIPTION (provided by applicant): Recently renamed Molecular and Cellular Bioenergetics, this Gordon Conference was last held in June, 2001, with the next meeting to be held June 22-27, 2003 at the Kimball Union Academy in Meriden, NH. The traditional focus of this meeting is on the mechanisms of oxidative phosphorylation and electron transport, and these continue to be central themes in the next conference. Aided by high resolution structural data on the F1F0 ATP synthase complex and by the application of novel dynamic measurements of rotary motion, important insights are emerging into the mechanism of proton-coupled ATP synthesis. Similarly, with the appearance of new high resolution structures of respiratory chain complexes, insights into the molecular mechanisms involved in electron transport, proton movement and the coupling between these two processes are also emerging. Moreover, this Conference has expanded to become a major platform for the discussion of mechanistic information obtained on integral membrane transport proteins using X-ray crystallography, spectroscopic techniques and molecular biological approaches. Recently discussed systems include bacteriorhodopsin, halorhodopsin and aquaporin, while the high resolution structure of the ABC transporters will be featured at the 2003 Conference. In addition, this meeting has also expanded into cellular bioenergetics and disease, with presentations in 2003 on the function and regulation of V-ATPases, the mechanism of assembly and targeting of bioenergetic complexes and the molecular basis of defects in copper absorption and resistance to intracellular parasites. The proposed meeting should thus accomplish the goal of presenting the cutting-edge research in the area of molecular and cellular bioenergetics. The participants at the Bioenergetics Gordon Conference include the leaders in this field, drawn from academics, government and industry, as well as more junior scientists, including many graduate students and Postdoctoral fellows, who represent the future of this area. A major use of the support sought in the current application is to assist such junior people in participating in this meeting. The Gordon Conference is organized to maximize the opportunity for discussion and for the presentation of the latest findings in this area, with poster sessions occurring every afternoon, discussion periods after each formal session and one entire morning devoted to workshops focused on short presentations by poster presenters.

描述（由申请人提供）：最近更名为分子和细胞生物能量学，本次戈登会议于2001年6月举行，下一次会议将于2003年6月22日至27日在新罕布什尔州梅里登的金博尔联合学院举行。本次会议的传统重点是氧化磷酸化和电子传递的机制，这些将继续是下次会议的中心主题。借助F1F0 ATP合成酶复合物的高分辨率结构数据和旋转运动的新动态测量的应用，质子偶联ATP合成机制的重要见解正在出现。同样，随着新的高分辨率呼吸链复合物结构的出现，对电子传递、质子运动以及这两个过程之间耦合的分子机制的见解也在出现。此外，该会议已扩大成为讨论利用x射线晶体学、光谱技术和分子生物学方法获得的整体膜运输蛋白的机制信息的主要平台。最近讨论的系统包括细菌视紫红质、盐视紫红质和水通道蛋白，而ABC转运蛋白的高分辨率结构将在2003年会议上展出。此外，该会议还扩展到细胞生物能量学和疾病，并在2003年发表了关于v - atp酶的功能和调控，生物能量复合物的组装和靶向机制以及铜吸收缺陷的分子基础和对细胞内寄生虫的抗性。因此，建议的会议应实现介绍分子和细胞生物能量学领域的前沿研究的目标。生物能量学戈登会议的参与者包括来自学术界、政府和工业界的这一领域的领导者，以及更多的初级科学家，包括许多研究生和博士后，他们代表了这一领域的未来。在当前申请中寻求支持的一个主要用途是帮助这些初级人员参加这次会议。戈登会议的组织是为了最大限度地提供讨论和展示这一领域最新发现的机会，每天下午都有海报会议，每次正式会议之后都有讨论时间，整个上午都专门用于研讨会，重点是海报演讲者的简短演讲。