Workshop on Receptor-Binding Radiotracers 2003

描述(由申请人提供)：拟举办的研讨会将汇集受体结合放射性示踪剂领域的主要专家。我们的目标将是总结我们的技术水平，并为未来的代理探索机会。我们的目标是重复2000年在拉霍亚举行的会议的形式和成功。这次会议名为受体结合放射性示踪剂研讨会，由美国能源部生物和环境科学办公室赞助，为同事们提供了一个小组环境，以在典型的科学会议上不可能的详细程度进行交流。 研讨会的范围将是多学科的，包括受体结合剂的合成化学、分析生物化学和物理化学。在21个演示中，有15个直接适用于癌症显像剂。此外，我们还将探讨当前和未来的成像仪器。我们将考虑广泛的靶向制剂：标记的小分子，标记的DNA和RNA探针，以及标记的抗体。最后，我们将讨论这些放射性示踪剂在临床上的应用，作为药物开发的探针和作为研究人体生理学的分析工具。参与者将包括放射化学家、数学家、生物化学家、药理学家、物理学家、核内科医生和临床医生。除了使用放射性配体作为受体的研究报告外，我们还将使用其他成像方式进行研究报告，以便从各个方面讨论成像领域。

DESCRIPTION (provided by applicant): The proposed Workshop will gather the leading experts within the field of receptor-binding radiotracers. Our objective will be to summarize the state of our art and to explore opportunities for future agents. Our goal is to repeat the format and success of the 2000 meeting held in La Jolla. Entitled Workshop for Receptor-Binding Radiotracers and sponsored by the DOE Office of Biological and Environmental Sciences, this meeting provided a small-group setting for colleagues to communicate at a level of detail that is not possible at typical scientific meetings. The scope of the Workshop will be multidisciplinary and include the synthetic chemistry, analytical biochemistry, and physical chemistry of receptor-binding agents. Fifteen of the twenty-one presentations apply directly to cancer imaging agents. Additionally, we will explore current and future imaging instrumentation. We will consider a wide spectrum of targeted agents: labeled small molecules, labeled DNA and RNA probes, and labeled antibodies. Lastly, we will discuss the application of these radiotracers as diagnostic agents in the clinic, as probes for drug development and as an analytical tool for investigation of human physiology. The participants will include radiochemists, mathematicians, biochemists, pharmacologists, physicists, nuclear physicians, and clinicians. In addition to research presentations using radioligands for receptors, we also will have research presentations using other imaging modalities in order to discuss the field of imaging from all aspects.