Drug Discovery & Biodiversity Conservation in Madagascar

药物发现

• 批准号: 6805213
• 负责人: IWAO OJIMA
• 金额: $ 19.82万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2006-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6805213
• 关键词: Africa; antimalarial agents; biological products; drug discovery /isolation; ecology; folk medicine; hot climate; international cooperation; medicinal plants; socioeconomics

DESCRIPTION (provided by applicant): This proposal requests funds to create a drug discovery program in Madagascar that will provide economic benefits and contribute to biodiversity conservation in the bio-rich moist forests surrounding Ranomafana National Park in southeastern Madagascar. The Institute for the Conservation of Tropical Environments (ICTE), based at Stony Brook University, will build on its 17 years experience in Madagascar to negotiate agreements with Malagasy officials and local traditional leaders, obtain permits and assist with the logistics of working in Madagascar. ICTE manages a research station in Ranomafana that will be used as the local base of operation and also supply some chemical laboratory space. The University of Antananarivo in Madagascar will continue the pursuit of ethnobotanical drug discovery leads while the California Academy of Sciences will expand its bio-survey activities to include bioprospecting and supply novel materials for extraction. The Institute for Chemical Biology and Drug Discovery (ICB&DD) at Stony Brook will provide expertise in structure determination, structure-activity relationship studies, and selection of drug candidates. INDENA SPA., a private company dedicated to the commercial development of pharmaceutical, health-food, and cosmetic products, which has a base of operations near Ranomafana, will be responsible for bulk purification and the commercial development of pure compounds and/or extracts. Initial drug discovery activities will focus on a traditional cough remedy and plants that appear to contain anti-malarial ingredients. The ICBG will work with experts in strategic planning and business development to plan sustainable economic incentives related to these drug discovery activities. The Group is dedicated to training Malagasy people in all aspects of drug discovery and to using the best practices towards developing both sustainable and fair commercial use of the biodiversity-rich resources of the Ranomafana region.

描述（由申请人提供）：本提案要求在马达加斯加建立一个药物发现项目，该项目将为马达加斯加东南部Ranomafana国家公园周围生物丰富的潮湿森林提供经济效益和生物多样性保护。设在Stony Brook大学的热带环境保护研究所（ICTE）将利用其在马达加斯加17年的经验，与马达加斯加官员和当地传统领导人谈判协议，获得许可并协助在马达加斯加开展工作的后勤工作。ICTE在Ranomafana管理一个研究站，该研究站将用作当地的操作基地，并提供一些化学实验室空间。马达加斯加的塔那那利佛大学将继续寻求民族植物药物发现的线索，而加州科学院将扩大其生物调查活动，包括生物勘探和提供用于提取的新材料。位于Stony Brook的化学生物学和药物发现研究所（ICB&DD）将提供结构测定、结构-活性关系研究和候选药物选择方面的专业知识。INDENA SPA。该公司是一家致力于医药、保健食品和化妆品商业开发的私营公司，在拉诺马法纳附近设有运营基地，将负责纯化合物和/或提取物的批量纯化和商业开发。最初的药物发现活动将侧重于传统的止咳药和似乎含有抗疟疾成分的植物。ICBG将与战略规划和业务发展方面的专家合作，规划与这些药物发现活动有关的可持续经济激励措施。该集团致力于在药物发现的各个方面对马达加斯加人进行培训，并采用最佳做法，对拉诺马法纳地区生物多样性丰富的资源进行可持续和公平的商业利用。