OSA in obese teens and preteens: Neurobehavioral effects

描述（由申请人提供）： 候选人Dean W。毕比博士，是辛辛那提儿童医院医学中心的儿科助理教授。这个K23应用程序将建立他的独立研究生涯，以患者为导向的研究儿童睡眠障碍的神经行为影响的性质，病因和可逆性。这将通过一个为期五年的培训方案和相关的研究项目来实现。培训计划有四个具体目标。首先，候选人将建立儿童和青少年正常和异常睡眠的生物学过程的工作知识，特别关注睡眠病理学可能导致神经行为症状的机制。这将提供睡眠的生理学和病理生理学的基本背景，再加上广泛接触到儿科睡眠障碍的诊断，测量和治疗。其次，候选人将加强他在纵向和流行病学研究设计和分析方面的培训，特别关注神经行为结果研究。这将提供所需的技能，胜任设计和执行在这一领域的独立研究。第三，候选人将提高他的科学写作和赠款建议的技能。最后，他将提高他的临床研究的道德行为的知识。这项培训将在来自领先的儿科部门和附近医学院的教师的指导下进行。主要赞助商是一个既定的研究人员在神经行为的影响，儿科疾病谁拥有成功的职业指导的历史。共同赞助者代表与研究和职业发展计划直接相关的子专业部门。拟议的研究计划集中在一个研究不足的人群，是在阻塞性睡眠呼吸暂停（OSA）的高风险：肥胖的青少年和青春期前。该计划的设计有两个总体目标：（1）加强对该人群中OSA神经行为症状的存在，性质和可逆性的科学理解，以及（2）扩大该领域对广义睡眠病理学对儿科神经行为功能影响的理解。利用候选人可用资源的独特组合，该项目将提供将睡眠病理学的生物学过程与其神经行为表现联系起来的研究方面的特殊培训，同时还将生成关于快速增长的人口的急需的科学数据，并且具有睡眠障碍和不良神经行为结果的重大风险。

DESCRIPTION (provided by applicant): The candidate, Dean W. Beebe, Ph.D., is an Assistant Professor of Pediatrics at Cincinnati Children's Hospital Medical Center. This K23 application will establish his independent research career in patient-oriented research into the nature, etiology and reversibility of the neurobehavioral effects of pediatric sleep disorders. This will be accomplished through a five-year training program and related research project. The training program has four specific objectives. First, the candidate will build a working knowledge of the biological processes that underlie normal and abnormal sleep in children and adolescents, with a particular focus on the mechanisms by which sleep pathology might cause neurobehavioral symptoms. This will provide an essential background in the physiology and pathophysiology of sleep, coupled with broad exposure to the diagnosis, measurement, and treatment of pediatric sleep disorders. Second, the candidate will enhance his training in longitudinal and epidemiological research design and analysis, with a particular focus on neurobehavioral outcome research. This will provide the skills needed to competently design and execute independent research in this area. Third, the candidate will improve his scientific writing and grant proposal skills. Finally, he will enhance his knowledge of the ethical conduct of clinical research. This training will take place under the guidance of faculty from a leading pediatric department and nearby medical school. The primary sponsor is an established researcher in the neurobehavioral effects of pediatric illness who has a history of successful career mentorship. Co-sponsors represent subspecialty divisions that are directly relevant to the research and career development plan. The proposed research plan focuses on an understudied population that is at high risk for obstructive sleep apnea (OSA): obese teens and preteens. This plan has been designed with two overarching goals: (1) to enhance scientific understanding of the presence, nature, and reversibility of neurobehavioral symptoms of OSA within this population, and (2) to expand the field's understanding of the effects of sleep pathology, broadly defined, on pediatric neurobehavioral functioning. Capitalizing on the unique combination of resources available to the candidate, this project will provide exceptional training in research linking the biological processes of sleep pathology with their neurobehavioral manifestations, while also generating much needed scientific data on a population that is rapidly growing and is at significant risk for both sleep disorders and poor neurobehavioral outcome.