Obstructive Sleep Apnea (OSA) in obese teens & preteens: Neurobahavioral effects

肥胖青少年的阻塞性睡眠呼吸暂停 (OSA)

• 批准号: 7174648
• 负责人: Dean W. Beebe
• 金额: $ 12.1万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-01-05 至 2008-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7174648
• 关键词: Address; Adherence; Adolescent; Adult; Apnea; Applications Grants; Area; Arousal; Behavior; Behavioral; Biological Process; Body Weight Changes; Body Weight decreased; Breathing; Caring; Child; Childhood; Chronic; Clinical; Clinical Research; Cognition; Cognitive; Continuous Positive Airway Pressure; Control Groups; Controlled Study; Coupled; Data; Depressed mood; Development Plans; Diagnosis; Diet; Doctor of Philosophy; Enrollment; Epidemic; Epidemiologic Research Design; Etiology; Evaluation; Event; Exposure to; Faculty; Foundations; Functional disorder; Goals; Home environment; Hospitals; Hour; Hypoxia; Incidence; Individual; Intervention; Knowledge; Link; Literature; Long-Term Effects; Measurement; Measures; Medical; Medical center; Mentorship; Monitor; Moods; Morbidity - disease rate; Nature; Neurobehavioral Manifestations; Obesity; Obstructive Sleep Apnea; Occupational Health; Operative Surgical Procedures; Outcome; Outcomes Research; Parents; Pathology; Patients; Pattern; Pediatric Hospitals; Pediatrics; Phase; Physicians; Physiology; Population; Problem behavior; Questionnaires; Recording of previous events; Relative (related person); Research; Research Personnel; Research Project Grants; Resources; Risk; Risk Factors; Sampling; Score; Severities; Sleep; Sleep Apnea Syndromes; Sleep Deprivation; Sleep Disorders; Social Environment; Symptoms; Teenagers; Testing; Time; Training; Training Programs; Work; Writing; actigraphy; aged; career; cognitive function; compliance behavior; design; improved; indexing; medical schools; neurobehavioral; neurodevelopment; novel; obesity treatment; patient oriented research; pediatric department; professor; programs; skills; social

DESCRIPTION (provided by applicant): The candidate, Dean W. Beebe, Ph.D., is an Assistant Professor of Pediatrics at Cincinnati Children's Hospital Medical Center. This K23 application will establish his independent research career in patient-oriented research into the nature, etiology and reversibility of the neurobehavioral effects of pediatric sleep disorders. This will be accomplished through a five-year training program and related research project. The training program has four specific objectives. First, the candidate will build a working knowledge of the biological processes that underlie normal and abnormal sleep in children and adolescents, with a particular focus on the mechanisms by which sleep pathology might cause neurobehavioral symptoms. This will provide an essential background in the physiology and pathophysiology of sleep, coupled with broad exposure to the diagnosis, measurement, and treatment of pediatric sleep disorders. Second, the candidate will enhance his training in longitudinal and epidemiological research design and analysis, with a particular focus on neurobehavioral outcome research. This will provide the skills needed to competently design and execute independent research in this area. Third, the candidate will improve his scientific writing and grant proposal skills. Finally, he will enhance his knowledge of the ethical conduct of clinical research. This training will take place under the guidance of faculty from a leading pediatric department and nearby medical school. The primary sponsor is an established researcher in the neurobehavioral effects of pediatric illness who has a history of successful career mentorship. Co-sponsors represent subspecialty divisions that are directly relevant to the research and career development plan. The proposed research plan focuses on an understudied population that is at high risk for obstructive sleep apnea (OSA): obese teens and preteens. This plan has been designed with two overarching goals: (1) to enhance scientific understanding of the presence, nature, and reversibility of neurobehavioral symptoms of OSA within this population, and (2) to expand the field's understanding of the effects of sleep pathology, broadly defined, on pediatric neurobehavioral functioning. Capitalizing on the unique combination of resources available to the candidate, this project will provide exceptional training in research linking the biological processes of sleep pathology with their neurobehavioral manifestations, while also generating much needed scientific data on a population that is rapidly growing and is at significant risk for both sleep disorders and poor neurobehavioral outcome.

描述(由申请人提供)： 候选人迪恩·W·毕比博士是辛辛那提儿童医院医学中心的儿科学助理教授。K23的这一应用将奠定他在以患者为导向的研究领域的独立研究生涯，研究儿童睡眠障碍的神经行为影响的性质、病因和可逆性。这将通过一个为期五年的培训计划和相关研究项目来实现。该培训计划有四个具体目标。首先，候选人将建立儿童和青少年正常和异常睡眠背后的生物过程的实用知识，特别关注睡眠病理可能导致神经行为症状的机制。这将提供睡眠生理学和病理生理学的基本背景，以及对儿童睡眠障碍的诊断、测量和治疗的广泛接触。其次，候选人将加强他在纵向和流行病学研究设计和分析方面的培训，特别是神经行为结果研究。这将提供在这一领域胜任设计和执行独立研究所需的技能。第三，候选人将提高他的科学写作和批准提案的技能。最后，他将提高他对临床研究道德行为的认识。培训将在一家领先的儿科部门和附近医学院的教职员工的指导下进行。主要赞助人是一位在儿科疾病的神经行为影响方面的知名研究人员，他有过成功的职业指导历史。联合赞助商代表与研究和职业发展计划直接相关的子专业部门。拟议的研究计划侧重于研究不足的人群，即阻塞性睡眠呼吸暂停(OSA)的高危人群：肥胖青少年和青春期前儿童。这项计划的设计有两个主要目标：(1)加强对该人群中阻塞性睡眠呼吸暂停综合征神经行为症状的存在、性质和可逆性的科学理解，以及(2)扩大该领域对广泛定义的睡眠病理学对儿童神经行为功能影响的理解。利用候选人可利用的独特资源组合，该项目将提供特殊的研究培训，将睡眠病理的生物过程与其神经行为表现联系起来，同时还将产生关于快速增长的、面临睡眠障碍和神经行为不良后果重大风险的人群的迫切需要的科学数据。