Cardiac disease in children with chronic renal failure
慢性肾功能衰竭儿童的心脏病
基本信息
- 批准号:6770189
- 负责人:
- 金额:$ 12.5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2002
- 资助国家:美国
- 起止时间:2002-08-20 至 2007-06-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (provided by applicant):
Cardiovascular disease (CVD) is the leading cause of death in adult and pediatric patients with end-stage renal disease (ESRD). Cardiovascular changes are frequently present in children with advanced renal failure. Left ventricular hypertrophy (LVH) is already highly prevalent in children at the initiation of chronic dialysis therapy, and remains prevalent during long-term dialysis and after renal transplantation. Exactly when these abnormalities first appear in the course of renal failure is not known. The fact that LVH is already prevalent at the time of entry to chronic dialysis strongly indicates that LV abnormalities develop during early chronic renal insufficiency (CRI). We also postulate that in addition to LVH, pediatric patients with CRI develop abnormalities of LV function as well as vascular abnormalities. The hypothesis underlying the proposal is that cardiovascular changes occur in children with relatively mild CRI, and progress as end-stage disease approaches. To test this concept, we will assess cardiac and vascular abnormalities and identify risk factors for these abnormalities in pediatric patients with CRI. Specifically, we will examine: 1. Cardiac structure by evaluation of LV mass, LV geometry; 2. LV systolic and diastolic function using rest and stress echocardiography; 3. Vascular structure by assessment of carotid artery intima-media thickness (IMT); 4. Vascular function by assessment of endothelium-mediated vasodilatation of the brachial artery using high-resolution B-mode ultrasound. In addition, we will determine the role of blood pressure by ambulatory blood pressure monitoring, anemia, etiology and rate of progression of CRI, hyperlipidemia and hyper-homocysteinemia as possible risk factors for cardiac or vascular abnormalities and assess the changes of cardiovascular structure and function by repeating the evaluation 2 years after initial examination. Evaluation of the relationships between LV structure, LV function, carotid IMT and endothelial function will help to gather the important information needed for future mechanistic studies of development of cardiovascular disease in children with CRI. By understanding the risk factors and temporal evolution by which cardiovascular abnormalities develop in these patients, we may then be able to develop and test preventive interventions. It is possible that mild-to-moderate CRI is the optimal time during which identification of modifiable risk factors and early intervention might lead to elective treatment and even to prevention of cardiac disease over the long term. Thus, the long-term goal will be to decrease the incidence and prevalence of cardiovascular disease in young adults who developed chronic renal disease during childhood.
描述(由申请人提供):
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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MARK M. MITSNEFES其他文献
MARK M. MITSNEFES的其他文献
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{{ truncateString('MARK M. MITSNEFES', 18)}}的其他基金
Cardiovascular Disease in Children with Chronic Kidney Disease
慢性肾病儿童的心血管疾病
- 批准号:
8027221 - 财政年份:2011
- 资助金额:
$ 12.5万 - 项目类别:
Cardiovascular Disease in Children with Chronic Kidney Disease
慢性肾病儿童的心血管疾病
- 批准号:
8497681 - 财政年份:2011
- 资助金额:
$ 12.5万 - 项目类别:
Cardiovascular Disease in Children with Chronic Kidney Disease
慢性肾病儿童的心血管疾病
- 批准号:
8262680 - 财政年份:2011
- 资助金额:
$ 12.5万 - 项目类别:
Adiponectin and Cardiovascular Disease in the CKiD Children
CKiD 儿童的脂联素与心血管疾病
- 批准号:
7766717 - 财政年份:2007
- 资助金额:
$ 12.5万 - 项目类别:
Adiponectin and Cardiovascular Disease in the CKiD Children
CKiD 儿童的脂联素与心血管疾病
- 批准号:
7315923 - 财政年份:2007
- 资助金额:
$ 12.5万 - 项目类别:
Adiponectin and Cardiovascular Disease in the CKiD Children
CKiD 儿童的脂联素与心血管疾病
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7677309 - 财政年份:2007
- 资助金额:
$ 12.5万 - 项目类别:
ABPM AND END ORGAN DAMAGE IN CHILDREN WITH RENAL TRANSPLANTATION
肾移植儿童的动态血压监测和终末器官损伤
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7374523 - 财政年份:2005
- 资助金额:
$ 12.5万 - 项目类别:
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