Vascular Dysfunction in Obesity and Metabolic Syndrome

肥胖和代谢综合征中的血管功能障碍

• 批准号: 7023644
• 负责人: Elaine Mott Urbina
• 金额: $ 12.8万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7023644
• 关键词: C reactive protein; adiponectin; adolescence (12-20); angiocardioultrasonography; biomarker; blood flow measurement; blood lipid; blood pressure; blood tests; body composition; cardiovascular disorder epidemiology; cardiovascular disorder risk; clinical research; diabetes risk; echocardiography; human subject; insulin sensitivity /resistance; metabolic syndrome; middle childhood (6-11); obesity; patient oriented research; pulse pressure wave; statistics /biometry

DESCRIPTION (provided by applicant): Candidate: During Pediatric Cardiology fellowship, I worked with Bogalusa Heart Study investigators and planned to continue a combined clinical/research career but personnel changes in my practice led to an increased clinical load frustrating my attempts to complete a Masters in Public Health. My goal of becoming an independent researcher in Pediatric CV disease epidemiology was left unfulfilled. When the chance came to join Cincinnati Children's Hospital, I embraced the challenge, eager to get my career back on track. This K23 award will be instrumental in providing me with the training I need to become an expert in Pediatric Vascular Function. Environment: Children's is the ideal environment for my transition back to a research career. My reduced clinical duties now focus on Preventive Cardiology, and I am enrolled in the Masters program at the University of Cincinnati. I have been provided up-to-date vascular equipment and numerous mentoring opportunities which have led to productive interdisciplinary relationships culminating in pilot data for 2 abstracts and in preparation of this K23 proposal. Research: Childhood obesity has increased dramatically in the U.S., and these children are at risk for target organ damage, adult diabetes, heart disease and stroke. One of the pathways by which obesity induces target organ damage may involve fat derived adiponectin's (APN) effect on vascular function. APN directly protects the vasculature and is reduced in obesity, its related inflammation and in coronary artery disease. Low levels are associated with insulin resistance and the dyslipidemia of metabolic syndrome. We propose a cross-sectional study of school-aged adolescents to study relationships between obesity and vascular function to determine if the mechanisms of dysfunction may relate to abnormal levels of CV risk factors, inflammation and APN. Brachial Artery Distensibility, BMI, BP, lipids, CRP, and APN will be measured in the ongoing Princeton Landmark Study (N=2000). A cohort sample (n=450) will also undergo brachial flow mediated dilatation, augmentation index and pulse wave velocity. Contrasts in laboratory & vascular measures will be made among normals, obese and obese-insulin-resistant subjects. Well-established and newer non-invasive methods of vascular function testing will be compared. Relevance: Showing that metabolic abnormalities related to overweight lead to blood vessel dysfunction in children will help doctors identify high-risk children for early treatment to prevent future heart attack and stroke.

描述（由申请人提供）： 候选人：在儿科心脏病学奖学金期间，我曾与Bogalusa心脏研究研究人员合作，并计划继续进行临床/研究职业的合并，但是我的实践中的人员变化导致了增加的临床负担，这使我无法完成公共卫生大师的尝试。我成为小儿CV疾病流行病学领域的独立研究人员的目标是无法实现的。当有机会加入辛辛那提儿童医院时，我接受了挑战，渴望使我的职业重回正轨。这项K23奖将有助于我为我成为小儿血管功能专家所需的培训。 环境：儿童是我过渡到研究职业的理想环境。我减少的临床职责现在集中在预防性心脏病学上，我正在辛辛那提大学的硕士课程中。我被提供了最新的血管设备和众多指导机会，这导致了富有生产力的跨学科关系，最终导致了2个摘要的试验数据，并准备了这项K23提案。 研究：在美国，儿童肥胖症急剧增加，这些儿童有靶心器官损害，成人糖尿病，心脏病和中风的风险。肥胖诱导靶器官损伤的途径之一可能涉及脂肪得出的脂联素（APN）对血管功能的影响。 APN直接保护脉管系统，并减少肥胖，其相关炎症和冠状动脉疾病。低水平与胰岛素抵抗和代谢综合征的血脂异常有关。我们建议对学龄前青少年进行横断面研究，以研究肥胖和血管功能之间的关系，以确定功能障碍的机制是否可能与CV风险因素，炎症和APN的异常水平有关。将在正在进行的普林斯顿地标研究（n = 2000）中测量臂动脉扩张，BMI，BP，脂质，CRP和APN。队列样品（n = 450）还将经历臂流介导的扩张，增强指数和脉冲波速度。实验室和血管措施的对比度将在正常，肥胖和肥胖的胰岛素耐药性受试者中进行。将比较建立良好和新的非侵入性血管功能测试方法。 相关性：表明与超重相关的代谢异常导致儿童血管功能障碍将帮助医生识别高危儿童早期治疗，以防止未来的心脏病发作和中风。