Metabolic Syndrome and Atherosclerosis in South Asians

描述（由申请人提供）： Alka Kanaya是加州大学旧金山分校弗朗西斯科的医学助理教授。她的长期职业目标是开发一个基于南亚成年人的前瞻性人群队列，以检查导致这一研究不足的人群中发病率极高的临床心血管疾病的前驱因素。在Stephen Hulley博士和Morris Schambelan博士的指导下，Kanaya博士提出了一个全面的多学科职业发展计划，包括遗传流行病学和高级统计课程，葡萄糖和脂质代谢和遗传研究领域的两个独立的临床研究学徒，以及实际的队列管理经验。这项名为“生活在美国的南亚人的代谢综合征和动脉粥样硬化”（MASALA）的研究计划是一项对南亚人社区样本的横断面研究，以确定胰岛素抵抗、代谢综合征、体脂分布、脂肪细胞因子、脂质减少和血栓形成因素是否与亚临床动脉粥样硬化独立相关。本研究以正在进行的国家心肺和血液研究所研究（动脉粥样硬化的多种族研究）为模型，采用相同的采样方法，合格标准，实验室测定和动脉粥样硬化测量，以便在多个种族中进行有效比较。该研究将招募150名年龄在55岁至84岁之间的南亚人，他们没有心血管疾病。符合条件的受试者将前往综合临床研究中心进行6小时访视，接受空腹血液检查、频繁采样的静脉葡萄糖耐量试验、问卷调查、人体测量、血压、全身DEXA、颈动脉超声以及心脏和腹部CT扫描。本研究的目的是：（1）确定胰岛素抵抗（IR）、代谢综合征和动脉粥样硬化的患病率， 南亚人;（2）检验内脏肥胖和脂肪细胞因子与IR相关的假设，以及IR、脂质亚组分和血栓形成标志物与动脉粥样硬化相关的假设，而不依赖于传统的心脏危险因素;以及（3）检验南亚人与梅萨登记的其他种族群体相比具有更高的代谢特征和动脉粥样硬化患病率的假设，IR和代谢因素解释了南亚人动脉粥样硬化患病率的增加。 (End摘要）

DESCRIPTION (provided by applicant): Alka Kanaya is Assistant Professor of Medicine at the University of California, San Francisco, in the Division of General Internal Medicine. Her long-term career goal is to develop a prospective population-based cohort of South Asian adults to examine the antecedants of clinical cardiovascular disease responsible for the disparately high rates of disease in this understudied population. Under the mentorship of Drs. Stephen Hulley and Morris Schambelan, Dr. Kanaya proposes a comprehensive multidisciplinary career development plan composed of genetic epidemiology and advanced statistical coursework, two separate clinical research apprenticeships in the fields of glucose and lipid metabolism and genetic studies, and practical cohort management experience. The research plan, titled the Metabolic Syndrome and Atherosclerosis in South Asians Living in America (MASALA), is a cross-sectional study of a community-based sample of South Asians to determine whether insulin resistance, the metabolic syndrome, body fat distribution, adipocytokines, lipid subtractions, and thrombosis factors are independently associated with subclinical atherosclerosis. This study is modeled on an ongoing National Heart Lung and Blood Institute study (the Multi-Ethnic Study of Atherosclerosis) with identical sampling methods, eligibility criteria, lab assays and atherosclerosis measures to allow for efficient comparisons across multiple ethnic groups. The study will recruit 150 South Asians between the ages of 55 and 84 without cardiovascular disease. Eligible participants will attend a General Clinical Research Center for a 6-hour visit to undergo fasting blood tests, frequently sampled intravenous glucose tolerance test, questionnaire, body anthropometry, blood pressure, whole body DEXA, carotid ultrasound, and cardiac and abdominal CT scan. Objectives of this study are to: (1) determine the prevalence of insulin resistance (IR), the metabolic syndrome, and atherosclerosis among South Asians; (2) test the hypotheses that visceral adiposity and adipocytokines are associated with IR, and that IR, lipid subfractions, and a thrombosis marker are associated with atherosclerosis independent of traditional cardiac risk factors; and (3) test the hypotheses that South Asians have higher prevalence of metabolic features and atherosclerosis compared with other ethnic groups enrolled in MESA, and that IR and metabolic factors explain the increased prevalence of atherosclerosis in South Asians. (End of Abstract)