Development of New Reagents for Protein Chemistry

蛋白质化学新试剂的开发

• 批准号: 2284188
• 金额: --
• 依托单位: University of Southampton
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2284188
• 关键词: Development; New; Reagents; Protein; Chemistry

This multidisciplinary project will be at the interface of the chemical and biological sciences, and will combine state-of-the-art synthetic organic chemistry with biochemical, analytical and biophysical methods. The project will focus on the development of novel biocompatible reagents and methodologies for the controlled chemical modification of peptides and proteins, and employ these methodologies to study the properties and function of key protein post-translational modifications (PTMs) using biochemical/biophysical assays. We are particularly interested in a range of PTMs resulting from cellular oxidative stress, which are currently impossible to study using conventional techniques. On the longer term, the new reagents and methods will unlock exciting opportunities for studying the so far elusive function of these PTMs in human biology, with potential implications in drug discovery and the treatment of diseases resulting from unregulated cellular redox events.

这个多学科项目将处于化学和生物科学的交叉领域，并将最先进的合成有机化学与生物化学、分析和生物物理方法相结合。该项目将重点开发用于肽和蛋白质受控化学修饰的新型生物相容性试剂和方法，并利用这些方法通过生化/生物物理测定来研究关键蛋白质翻译后修饰（PTM）的特性和功能。我们对细胞氧化应激产生的一系列 PTM 特别感兴趣，目前无法使用传统技术进行研究。从长远来看，新的试剂和方法将为研究这些 PTM 在人类生物学中迄今为止难以捉摸的功能提供令人兴奋的机会，对药物发现和治疗因不受调控的细胞氧化还原事件引起的疾病具有潜在影响。