Nanostructured, Liquid Crystalline Dental Restoratives

纳米结构液晶牙科修复剂

• 批准号: 6608782
• 负责人: SCOTT R SCHRICKER
• 金额: $ 14.75万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-01 至 2005-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6608782
• 关键词: X ray crystallography; biomaterial development /preparation; biomaterial evaluation; biomaterial interface interaction; composite resins; crystallins; dental material wear; monomer; nanotechnology; oral facial restoration material; physical property; polymerization; polymers; restorative dentistry; tensile strength; transmission electron microscopy

DESCRIPTION: The goal of this application is to synthesize a nanostructured thermoset for use as a Dental restorative. A nanostructured thermoset will have superior properties to conventional composite materials. Bone and teeth are examples of nanostructured composites and our goal is to take advantage and mimic the nanoscale control found in these materials. Nanoscale building blocks will be synthesized and used to form nanostructured thermosets with superior mechanical properties. Simple modifications to the structure of the building blocks will affect the bulk properties of the thermosets. The molecular building blocks can act as a platform to develop a broad range of functional materials. Liquid crystalline organic-inorganic hybrids based on polyhedral silsesquioxane (POSS) will be used as the building blocks. POSS contains both organic and inorganic components so controlled composite structures can be formulated without the inherent problems of mixing. The liquid crystalline phase will impart nanoscale order to the liquid crystalline building blocks. To retain the nanoscale order, the liquid crystalline POSS will be made visible light curable with the addition of methacrylate groups. Irradiation with visible light will form a thermoset that will retain the nanoscale order of the liquid crystalline phase. The thermosets will be evaluated by X-ray diffraction and TEM to confirm their nanostructure. Conventional evaluations for clinical performance such as flexural strength, compressive strength, shrinkage and wear will be performed. This application represents a new methodology in the design of dental restoratives.

描述：此应用程序的目的是合成纳米结构的热固性用作牙科修复。纳米结构的热固性人员将具有与常规复合材料具有优越性的特性。骨骼和牙齿是纳米结构复合材料的例子，我们的目标是利用并模仿这些材料中发现的纳米级控制。纳米级的构建块将被合成，并用于形成具有出色机械性能的纳米结构热固性。对构建块结构的简单修改将影响热固件的批量特性。分子构建块可以充当开发各种功能材料的平台。基于多面体硅氧烷（POSS）的液晶有机无机杂种将用作构建块。 POSS包含有机和无机成分，因此可以制定受控的复合结构而没有固有的混合问题。液晶相将纳米级秩序施加到液晶构建块。为了保留纳米级阶，通过添加甲基丙烯酸酯基团可以使液晶可能可见。带有可见光的辐射将形成一个热固性，该热是将保留液晶相的纳米级顺序。热固性将通过X射线衍射和TEM评估以确认其纳米结构。将进行常规评估临床性能，例如弯曲强度，抗压强度，收缩和磨损。该应用程序代表了牙科修复设计设计的一种新方法。