Nanostructured, Liquid Crystalline Dental Restoratives

描述：本应用程序的目的是合成一种纳米结构的热固性材料，用于牙科修复。纳米结构的热固性材料将比传统的复合材料具有更优越的性能。骨和牙齿是纳米结构复合材料的例子，我们的目标是利用和模仿这些材料中的纳米级控制。纳米级建筑模块将被合成并用于形成具有优异机械性能的纳米结构热固性材料。对构件结构的简单修改将影响热固性材料的整体性能。分子构建块可以作为开发各种功能材料的平台。基于多面体硅氧烷（POSS）的液晶有机-无机杂化物将被用作构建模块。POSS包含有机和无机成分，因此可以在没有混合固有问题的情况下制定可控的复合结构。液晶相将赋予液晶构建块纳米级的秩序。为了保持纳米级的秩序，液晶POSS将通过添加甲基丙烯酸酯基团使其在可见光下固化。用可见光照射将形成热固性材料，它将保持液晶相的纳米级秩序。热固性材料将通过x射线衍射和透射电镜进行鉴定，以确定其纳米结构。临床表现的常规评估，如抗弯强度，抗压强度，收缩和磨损将被执行。这一应用代表了一种新的方法，在牙科修复设计。

DESCRIPTION: The goal of this application is to synthesize a nanostructured thermoset for use as a Dental restorative. A nanostructured thermoset will have superior properties to conventional composite materials. Bone and teeth are examples of nanostructured composites and our goal is to take advantage and mimic the nanoscale control found in these materials. Nanoscale building blocks will be synthesized and used to form nanostructured thermosets with superior mechanical properties. Simple modifications to the structure of the building blocks will affect the bulk properties of the thermosets. The molecular building blocks can act as a platform to develop a broad range of functional materials. Liquid crystalline organic-inorganic hybrids based on polyhedral silsesquioxane (POSS) will be used as the building blocks. POSS contains both organic and inorganic components so controlled composite structures can be formulated without the inherent problems of mixing. The liquid crystalline phase will impart nanoscale order to the liquid crystalline building blocks. To retain the nanoscale order, the liquid crystalline POSS will be made visible light curable with the addition of methacrylate groups. Irradiation with visible light will form a thermoset that will retain the nanoscale order of the liquid crystalline phase. The thermosets will be evaluated by X-ray diffraction and TEM to confirm their nanostructure. Conventional evaluations for clinical performance such as flexural strength, compressive strength, shrinkage and wear will be performed. This application represents a new methodology in the design of dental restoratives.