Nanostructured, Liquid Crystalline Dental Restoratives

纳米结构液晶牙科修复剂

• 批准号: 6721465
• 负责人: SCOTT R SCHRICKER
• 金额: $ 14.75万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6721465
• 关键词: X ray crystallography; biomaterial development /preparation; biomaterial evaluation; biomaterial interface interaction; composite resins; crystallins; dental material wear; monomer; nanotechnology; oral facial restoration material; physical property; polymerization; polymers; restorative dentistry; tensile strength; transmission electron microscopy

DESCRIPTION: The goal of this application is to synthesize a nanostructured thermoset for use as a Dental restorative. A nanostructured thermoset will have superior properties to conventional composite materials. Bone and teeth are examples of nanostructured composites and our goal is to take advantage and mimic the nanoscale control found in these materials. Nanoscale building blocks will be synthesized and used to form nanostructured thermosets with superior mechanical properties. Simple modifications to the structure of the building blocks will affect the bulk properties of the thermosets. The molecular building blocks can act as a platform to develop a broad range of functional materials. Liquid crystalline organic-inorganic hybrids based on polyhedral silsesquioxane (POSS) will be used as the building blocks. POSS contains both organic and inorganic components so controlled composite structures can be formulated without the inherent problems of mixing. The liquid crystalline phase will impart nanoscale order to the liquid crystalline building blocks. To retain the nanoscale order, the liquid crystalline POSS will be made visible light curable with the addition of methacrylate groups. Irradiation with visible light will form a thermoset that will retain the nanoscale order of the liquid crystalline phase. The thermosets will be evaluated by X-ray diffraction and TEM to confirm their nanostructure. Conventional evaluations for clinical performance such as flexural strength, compressive strength, shrinkage and wear will be performed. This application represents a new methodology in the design of dental restoratives.

描述：本申请的目标是合成一种纳米结构的热固性材料，用作牙科修复材料。纳米结构的热固性材料将具有比常规复合材料优越的上级性能。骨骼和牙齿是纳米结构复合材料的例子，我们的目标是利用和模仿在这些材料中发现的纳米级控制。纳米尺度的建筑块将被合成并用于形成具有上级机械性能的纳米结构热固性材料。对结构单元结构的简单修改将影响热固性材料的整体性能。分子构建块可以作为开发各种功能材料的平台。基于多面体倍半硅氧烷（POSS）的液晶有机-无机杂化物将被用作构建块。POSS含有有机和无机成分，因此可以配制受控的复合结构，而没有混合的固有问题。液晶相将赋予液晶结构单元纳米级顺序。为了保持纳米级，液晶POSS将通过添加甲基丙烯酸酯基团而被制成可见光固化的。用可见光照射将形成热固性材料，其将保持液晶相的纳米级。将通过X射线衍射和TEM对热固性材料进行评估，以确认其纳米结构。将对临床性能进行常规评价，如弯曲强度、压缩强度、收缩和磨损。该应用代表了牙科替代品设计的新方法。