Diagnostic Technology Based on Acoustic Radiation Force

基于声辐射力的诊断技术

• 批准号: 6598974
• 负责人: Armen Sarvazyan
• 金额: $ 14.9万
• 依托单位: ARTANN LABORATORIES, INC.
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-01 至 2005-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6598974
• 关键词: biosensor device; bone imaging /visualization /scanning; clinical biomedical equipment; diagnosis design /evaluation; musculoskeletal imaging /visualization /scanning; musculoskeletal system; technology /technique development; telemetry

DESCRIPTION (provided by applicant): The goal of the project is development of a physical and technical foundation for novel medical diagnostic technologies based on the use of ultrasonic RF as a virtual finger for remote probing of internal tissues. The milestones of the project include development of an experimental system for RF generation in model objects, for testing and validation of RF transmitters operating over a wide range of frequencies, design of a Doppler system for remote detection of RF induced acoustic signals, comprehensive mathematical analysis of RF generation in biological tissues, and laboratory model studies on RF induced local and oscillations waves in bones and heterogeneous soft tissues. The project will culminate in analyzing the applications of RF based methods in areas of medical diagnostics where the proposed technology has advantages over conventional approaches such as brain assessment; evaluation of muscle dynamic characteristics, assessment of hip fragility and monitoring the growth and ossification of infant's bones. The project is based on several innovations in different areas of physical and medical acoustics, such as use of acoustic RF for remote assessment of bones, Shear Wave Elasticity Imaging, Time Reversal focusing of ultrasonic beams, and remote evaluation of soft tissue shear viscosity.

描述（由申请人提供）： 该项目的目标是为新型医疗诊断技术开发物理和技术基础，该技术基于使用超声波射频作为虚拟手指来远程探测内部组织。 该项目的里程碑包括开发模型对象中射频生成的实验系统，用于测试和验证在宽频率范围内运行的射频发射器，设计用于远程检测射频感应声信号的多普勒系统，对生物组织中射频生成的综合数学分析，以及对骨骼和异质软组织中射频感应局部波和振荡波的实验室模型研究。 该项目最终将分析基于射频的方法在医疗诊断领域的应用，其中所提出的技术比大脑评估等传统方法具有优势；评估肌肉动态特征、评估髋部脆弱性并监测婴儿骨骼的生长和骨化。 该项目基于物理和医学声学不同领域的多项创新，例如使用声学射频远程评估骨骼、剪切波弹性成像、超声波束时间反转聚焦以及软组织剪切粘度远程评估。