Portable device for monitoring water balance in elderly

便携式老年人水平衡监测装置

• 批准号: 8371203
• 负责人: Armen Sarvazyan
• 金额: $ 14.7万
• 依托单位: ARTANN LABORATORIES, INC.
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8371203
• 关键词: Address; Affect; Anatomy; Binding; Blood; Blood Pressure; Body Water; Body Weight Changes; Body mass index; Body measure procedure; Caregivers; Caring; Clinical; Clinical Research; Cognitive; Data; Dehydration; Dementia; Detection; Development; Devices; Diagnosis; Diagnostic; Dizziness; Documentation; Elasticity; Elderly; Equilibrium; Esthesia; Fatty acid glycerol esters; Fluid Balance; Gender; Goals; Hand; Headache; Health; Health Professional; Health Promotion; Healthcare; Home environment; Hour; Hydration status; Impaired Renal Function; Individual; Laboratories; Legal patent; Life; Lightheadedness; Liquid substance; Magnetic Resonance Imaging; Measurement; Measures; Methods; Metric; Monitor; Morbidity - disease rate; Muscle; Nausea; Nursing Homes; Output; Patients; Personal Satisfaction; Phase; Physical Examination; Physiologic pulse; Psyche structure; Relative (related person); Reporting; Research; Risk; Sensory; Signs and Symptoms; Skin; Small Business Innovation Research Grant; Specific Gravity; Speed; Staging; Sweat; System; Technology; Testing; Thirst; Time; TimeLine; Tissues; Translational Research; Ultrasonics; Ultrasonography; Urine; Validity and Reliability; Variant; Water; Water Intoxication; Xerostomia; age related; aging population; animal tissue; base; cost; design; functional decline; high risk; mental state; monitoring device; mortality; motor impairment; new technology; novel; older patient; phase 1 study; prototype; soft tissue; success; tissue phantom; tool

DESCRIPTION (provided by applicant): Dehydration is a frequent cause of morbidity and mortality in the elderly. Identifying at risk individuals and maintaining adequate fluid balance is an essential component of health care in the aging population. Currently, there is no effective tool available to measure hydration status and distinguish those at risk. The reliability and validity of current hydration assessment methods and criteria such as thirst, skin turgor, blood pressure, pulse, urine output and specific gravity, MRI, dilution methods and bioimpedance, are limited, and the methods are inaccurate or expensive. Given that dehydration is both preventable and reversible, the need for an easy- to-perform method for the detection of water imbalance is of the utmost clinical importance. The goal of this project is to develop an inexpensive and easy-to-use device that monitors changes in hydration status and predict those at risk in home-bound and institutionalized elderly. We propose to develop the Hydration Monitor (HM) that can objectively quantify changes in the body water content and hydration status. The method implemented in the device is based on the experimental fact that ultrasound velocity through soft tissue is a linear function of the tissue water content. Because muscle provides the largest body reservoir for water, the assessment of water imbalance is conducted by measuring speed of ultrasound in muscle. Preliminary studies confirmed feasibility of Hydration Monitor, a compact hand-held device based on a proprietary ultrasonic technology developed in Artann Laboratories. The aims of this Phase I SBIR project include (1) designing and manufacturing of HM prototype, which will be tested for its ability of measuring ultrasound velocity in water as test medium with accuracy better than 1 m/s; (b) testing and validating HM prototype on tissue phantoms and excised animal tissues, demonstrating the sensitivity to water content changes should be better than 2%; and (3) designing the HM ¿-prototype and preparing documentation for building the HM ¿-prototype in Phase II of the project for clinical studies. PUBLIC HEALTH RELEVANCE: Currently, there is no effective tool available to measure body dehydration, which is a frequent cause of morbidity and mortality in the elderly. We propose to develop a compact hand-held Hydration Monitor that can objectively quantify changes in the body water content and assess hydration status. The device is based on a proprietary patented ultrasonic technology developed in Artann Laboratories.

描述（由适用提供）：脱水通常是古老的发病率和死亡率的原因。确定处于危险的人并维持足够的液体平衡是老龄化人群中医疗保健的重要组成部分。当前，尚无有效的工具来衡量水合状态并区分有风险的水平。当前水合评估方法和标准的可靠性和有效性，例如第三，皮肤繁琐，血压，脉搏，尿液输出和特定重力，MRI，稀释方法和生物阻抗有限，这些方法不准确或昂贵。鉴于脱水既可以预防又可逆，因此需要一种易于表现的方法来检测水不平衡是至关重要的。该项目的目的是开发一种廉价且易于使用的设备，该设备可以监视水合状态的变化，并预测家庭界和制度化的风险。老年。我们建议开发可以客观地量化身体水含量和水合状态的变化的水合监测仪（HM）。该设备中实现的方法是基于实验事实，即通过软组织的超声速度是组织水含量的线性函数。由于肌肉为水提供了最大的身体储层，因此通过测量肌肉超声速度来进行水不平衡评估。初步研究证实了水合监测仪的可行性，水合作用力是一种基于Artann Laboratore开发的专有超声技术的紧凑型手持设备。该阶段I SBIR项目的目的包括（1）HM原型的设计和制造，将测试其在水中测量超声速度作为测试培养基的能力，其精度优于1 m/s； （b）在组织幻像和出色的动物时机上测试和验证HM原型，证明对水含量变化的敏感性应大于2％； （3）设计HM�-型和准备文档，以在临床研究项目的第二阶段构建HM�-概况。 公共卫生相关性：目前，没有可用于测量人体脱水的有效工具，这通常是造成发病率和死亡率的原因。我们建议开发一个紧凑的手持水合监测仪，该监视器可以客观地量化体内水含量和评估水合状态的变化。该设备基于Artann实验室开发的专有专利的超声技术。