Muscle viscosity as a protective mechanism for absorbing mechanical shock

肌肉粘度作为吸收机械冲击的保护机制

• 批准号: 8734322
• 负责人: Armen Sarvazyan
• 金额: $ 19.28万
• 依托单位: ARTANN LABORATORIES, INC.
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-13 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8734322
• 关键词: Acoustics; Aging; Back; Beginning of Life; Binding; Binding Sites; Biological; Biomechanics; Bone Density; Bursitis; Calibration; Cartilage; Characteristics; Contracts; Data; Degenerative polyarthritis; Development; Devices; Disease; Disinfection; Effectiveness; Elderly; Elements; Environment; Evaluation; Evolution; Filament; Fingers; Floor; Fracture; Gerontology; Goals; Hand; Head; Human; Individual; Inflammatory; Joints; Life; Light; Literature; Measures; Mechanics; Medical; Metabolic; Methods; Microfilaments; Modeling; Molecular; Monitor; Motor Neuron Disease; Muscle; Muscle Contraction; Muscular Dystrophies; Musculoskeletal System; Myopathy; Myosin ATPase; Occupational Medicine; Oceans; Osteoporosis; Performance; Phase; Physical Medicine; Physical activity; Pilot Projects; Play; Probability; Property; Publishing; Radiation; Real-Time Systems; Relaxation; Reproducibility; Resolution; Role; Running; Safety; Shock; Skeletal Muscle; Slide; Soccer; Sports Medicine; Stress; System; Technology; Tendinitis; Testing; Time; Tissues; Ultrasonography; Validation; Viscosity; Walking; Wrestling; absorption; age related; arthropathies; base; bone; clinical application; design; in vivo; instrument; mathematical model; muscle form; physical model; prophylactic; prototype; public health relevance; skeletal unloading; soft tissue; theories; tool; viscoelasticity

DESCRIPTION (provided by applicant): The ability of muscle to redistribute the energy of mechanical shock in time and space and unload skeletal joints is of key importance in physical activities, such as running and jumping, playing soccer, wrestling, etc. The impacts that occur during such activities may exceed the level that can be tolerated by cartilage pads between joints which cushion the moderate impacts accompanying mundane activities such as walking. We hypothesize that dissipation of mechanical energy of external impacts to absorb mechanical shock is a fundamental function of skeletal muscle and the viscosity of the skeletal muscle is a variable parameter which can be voluntarily controlled by changing the tension of the contracting muscle. We further hypothesize that an ability of muscle to absorb shock had been developed in the course of biological evolution, allowing the life to move from the ocean to land, from hydrodynamic to aerodynamic environment with dramatically different loading conditions for musculoskeletal system. To date there are no available practical tools for assessment of muscle dynamic viscosity. We propose to develop a compact and easy-to-use instrument for assessment of viscoelastic properties of skeletal muscle in vivo that can be used in exploring the mechanism and the ability of muscle in reducing the harmful effect of external impacts on bones and joints. The device will be based on the use of an acoustic radiation force impulse to generate localized displacements in tissue and the resulting displacements will be tracked during relaxation using cross-correlation based methods. The goals of this project include bench-testing of the developed device on muscle phantoms and conducting preliminary pilot study on a limited group of athletes demonstrating feasibility of the proposed technology. Experimental data obtained in vivo will be compared with theoretical predictions of the mathematical model for the molecular mechanism of the muscle viscosity. Quantitative assessment of muscle viscosity may shed light to many problems of medical biomechanics and sports medicine. The list of muscle disorders that can be assessed by a device for quantitative assessment of muscle viscoelasticity includes muscle dystrophy, motor neuron diseases, inflammatory and metabolic myopathies and many more. Monitoring muscle viscosity could help in anticipating joint diseases, such as tendonitis, bursitis and osteoarthritis and decreasing the probability of osteoporotic bone fracture. The fields of potential applications of such device include general clinical applications; rehabilitation and occupational medicine; sports medicine: assessment of muscle condition and performance in athletes; gerontology: assessment of muscle changes in aging, particularly following total weakening of musculoskeletal system during osteoporosis and osteoarthritis, and estimation of the prophylactics efficacy.

描述（由申请人提供）：肌肉在时间和空间和卸载骨骼关节上重新分配机械冲击能量的能力在体育活动中至关重要，例如跑步和跳跃，踢足球，摔跤等。在这种活动中发生的影响可能超过可以超过的水平，这些水平可以通过伴随中心的关节造成的软骨垫，而伴随着伴随的辅助效果。我们假设外部影响的机械能量吸收机械休克的耗散是骨骼肌的基本功能，而骨骼肌的粘度是可变参数，可以通过改变合同肌肉的张力来自愿控制。我们进一步假设，在生物进化过程中，已经发展了肌肉吸收冲击的能力，从而使生命从海洋转变为陆地，从流体动力学到空气动力学环境，具有巨大不同的肌肉骨骼系统的负载条件。迄今为止，还没有可用的实用工具来评估肌肉动态粘度。我们建议开发一种易于使用的仪器，以评估体内骨骼肌的粘弹性特性，可用于探索肌肉减少对骨骼和关节外部影响的有害影响的机制和能力。该设备将基于使用声辐射力脉冲来产生组织中的局部位移，并在使用基于互相关的方法的情况下跟踪所得的位移。该项目的目标包括对开发的肌肉幻像进行的台式测试以及对有限的运动员进行初步试点研究，以证明拟议技术的可行性。在体内获得的实验数据将与肌肉粘度分子机制的数学模型的理论预测进行比较。肌肉粘度的定量评估可能会使医学生物力学和运动医学的许多问题阐明。可以通过设备进行评估以评估肌肉粘弹性的肌肉疾病清单包括肌肉营养不良，运动神经元疾病，炎症和代谢肌病等。监测肌肉粘度可以帮助预测关节疾病，例如肌腱炎，囊炎和骨关节炎，并降低骨质疏松性骨折的可能性。这种设备的潜在应用领域包括一般临床应用；康复和职业医学；运动医学：评估运动员的肌肉状况和表现；老年学：评估衰老的肌肉变化，尤其是在骨质疏松和骨关节炎期间肌肉骨骼系统的总弱化之后，并估计了预防性功效。