Diagnostic Technology Based on Acoustic Radiation Force

基于声辐射力的诊断技术

• 批准号: 6726860
• 负责人: Armen Sarvazyan
• 金额: $ 14.9万
• 依托单位: ARTANN LABORATORIES, INC.
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-01 至 2005-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6726860
• 关键词: biosensor device; bone imaging /visualization /scanning; clinical biomedical equipment; diagnosis design /evaluation; musculoskeletal imaging /visualization /scanning; musculoskeletal system; technology /technique development; telemetry

DESCRIPTION (provided by applicant): The goal of the project is development of a physical and technical foundation for novel medical diagnostic technologies based on the use of ultrasonic RF as a virtual finger for remote probing of internal tissues. The milestones of the project include development of an experimental system for RF generation in model objects, for testing and validation of RF transmitters operating over a wide range of frequencies, design of a Doppler system for remote detection of RF induced acoustic signals, comprehensive mathematical analysis of RF generation in biological tissues, and laboratory model studies on RF induced local and oscillations waves in bones and heterogeneous soft tissues. The project will culminate in analyzing the applications of RF based methods in areas of medical diagnostics where the proposed technology has advantages over conventional approaches such as brain assessment; evaluation of muscle dynamic characteristics, assessment of hip fragility and monitoring the growth and ossification of infant's bones. The project is based on several innovations in different areas of physical and medical acoustics, such as use of acoustic RF for remote assessment of bones, Shear Wave Elasticity Imaging, Time Reversal focusing of ultrasonic beams, and remote evaluation of soft tissue shear viscosity.

描述（由申请人提供）： 该项目的目的是基于使用超声RF作为虚拟手指来远程探测内部组织的新型医学诊断技术的物理和技术基础。 该项目的里程碑包括开发用于模型对象中RF生成的实验系统，用于测试和验证在广泛频率上运行的RF发射器，用于远程检测RF诱导的声学信号的设计，对生物组织中RF的全面数学分析以及对RF诱导的RF诱导的rofe soscils waves waves waves waves的设计全面检测。 该项目将最终在分析基于RF的方法在医学诊断领域的应用，在这些领域中，所提出的技术比大脑评估等传统方法具有优势；评估肌肉动态特征，评估髋关节脆弱性以及监测婴儿骨骼的生长和骨化。 该项目基于物理和医学声学不同领域的几项创新，例如使用声学RF远程评估骨骼，剪切波弹性成像，超声梁的时间逆转聚焦以及软组织剪切粘度的远程评估。