Respirable ciprofloxacin aerosol for inhaled anthrax

用于吸入炭疽的可吸入环丙沙星气雾剂

• 批准号: 6823407
• 负责人: BROOKS MICHAEL HYBERTSON
• 金额: $ 7.7万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6823407
• 关键词: Bacillus anthracis; alveolar macrophages; anthrax; bioterrorism /chemical warfare; carbon dioxide; ciprofloxacin; drug design /synthesis /production; inhalation drug administration; laboratory rat; lymph nodes; particle; pharmacokinetics; respiratory infections; tissue /cell culture

DESCRIPTION (provided by applicant): Pulmonary delivery of solid ciprofloxacin aerosol particles is an attractive possibility for chasing anthrax spores into the thoracic lymph nodes and killing the bacteria when the spores germinate. The overall goal of this project is to develop a method in which inhaled micron-sized particles of ciprofloxacin can be used to benefit victims of inhalational anthrax. We hypothesize that aerosol administered particles of Upophilic ciprofloxacin will be taken up by alveolar macrophages and transported to the thoracic lymph nodes where inhaled anthrax spores vegetate into active bacteria. Our strategy is intended to put the antibiotic at high and sustained concentrations within alveolar macrophages in lung and lymph locations. We anticipate that as the ciprofloxacin particles dissolve, the drug may be released within alveolar macrophages that contain or are near to other cells that contain spores, and be able to kill the bacteria when they germinate. Although several water-soluble antibiotics, including tobramycin, have been formulated for pulmonary delivery as inhaled aerosols, respirable particles of highly lipophilic antibiotics like ciprofloxacin have not, although others are examining the formation of liposomal ciprofloxacin. We have developed an effective method for aerosol delivery of lipophilic drugs based on the use of supercritical carbon dioxide as solvent and propellant. Our goals for this pilot project are to determine whether supercritical fluid drug aerosolization will allow inhalation delivery of ciprofloxacin to the lungs, to determine the uptake and dissolution properties of ciprofloxacin particles in cultured alveolar macrophages, to investigate ciprofloxacin particle translocation to the thoracic lymph nodes, and to determine the pharmacokinetic parameters. Our overall goal is to create a new tool for targeted treatment or prophylaxis for victims of anthrax spore inhalation.

描述（由申请人提供）：肺输送固体环丙沙星气溶胶颗粒是一种有吸引力的可能性，可以将炭疽孢子追赶到胸部淋巴结并在孢子萌发时杀死细菌。