A Cancer Study Among Female Veterans in Texas, 1979-2001

1979-2001 年德克萨斯州女性退伍军人癌症研究

• 批准号: 6889360
• 负责人: SALLY W. VERNON
• 金额: $ 7.36万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6889360
• 关键词: breast neoplasms; cancer risk; cervix neoplasms; clinical research; female; human data; longitudinal human study; military personnel; neoplasm /cancer epidemiology; occupational hazard; ovary neoplasms; racial /ethnic difference; uterus neoplasms; veterans

DESCRIPTION (provided by applicant): This population-based, occupational cohort study will examine the association of military service with cancer risk in the U.S. female veteran population in Texas. Characteristics related to veteran status may predispose this cohort to gender-specific health problems. Potential risk factors include environmental exposures during wartime service, traumatic events associated with military service, and hormone-dependent factors associated with reproductive history. Previous research reports gynecologic cancers as the leading type of cancer among women veterans. The primary study aim is to examine breast, uterine corpus, cervical and ovarian cancer incidence (1995 to 2001) and mortality (1979 to 2001) rates among female veterans residing in Texas. The Department of Veterans Affairs' National Registry of Women Veterans (NRVW), a database of over 1.4 million women veterans who served during the period 1946 to 1995 will be cross-linked using probabilistic linking techniques with Texas vital statistics (mortality study) and Texas Cancer Registry (incidence study). A secondary study aim is to examine mortality and incidence of all other cancers. Potential explanatory variables to be examined are rank, branch of service, length of service, military pay grade, service in the Vietnam or Persian Gulf War theaters, military occupational status and military era served. Age- and race- standardized incidence ratios (SIRs), mortality ratios (SMRs), and proportional mortality ratios (SPMRs) will be computed using cancer rates in the Texas female population as the external standard for comparison. All potential explanatory variables will be considered simultaneously using Poisson regression. SIRs and proportional mortality ratios will be calculated using current age-, state-, and military-specific denominator data. The proposed study population is racially diverse and represents multiple generations and eras of military service. This study will provide pilot data as a basis for more extensive analytic, population-based cancer research aimed at veteran women. The linkage methodology uses an existing and underused database, contributing new information to the sparse body of research on women veterans and serving as a potential model for future gender-specific veteran health research. This research will further knowledge of the health needs of women veterans, serving to identify needed health services and to guide health policy, and will provide a basis for research agendas aimed at this growing occupational cohort.

描述(由申请人提供)： 这项以人群为基础的职业队列研究将在德克萨斯州的美国女性退伍军人群体中调查服兵役与癌症风险的关系。与退伍军人身份相关的特征可能会使这一群体容易出现性别特有的健康问题。潜在的危险因素包括战时服役期间的环境暴露，与服兵役有关的创伤事件，以及与生育史有关的激素依赖因素。此前的研究报告称，妇科癌症是退伍军人中的主要癌症类型。主要研究目的是调查居住在德克萨斯州的女性退伍军人的乳腺癌、子宫体、宫颈癌和卵巢癌发病率(1995年至2001年)和死亡率(1979年至2001年)。退伍军人事务部的全国女退伍军人登记处(NRVW)是一个数据库，其中包括1946年至1995年期间服役的140多万名女退伍军人，它将利用概率链接技术与德克萨斯州生命统计(死亡率研究)和德克萨斯州癌症登记处(发病率研究)相关联。第二项研究的目的是检查所有其他癌症的死亡率和发病率。需要研究的潜在解释变量包括军衔、军种、服役年限、军人薪级、在越南或波斯湾战争战场的服役情况、军事职业地位和服役时间。年龄和种族标准化发病率(SIRS)、死亡率(SMR)和比例死亡率(SPMR)将使用德克萨斯州女性人口的癌症发病率作为比较的外部标准来计算。所有潜在的解释变量将使用泊松回归同时考虑。SIRS和比例死亡率将使用当前特定年龄、州和军队的分母数据来计算。拟议的研究人群是种族多样化的，代表了多代人和多个时代的服兵役。这项研究将提供试点数据，作为针对退伍军人的更广泛的分析性、基于人群的癌症研究的基础。这种联系方法使用了一个现有的、未得到充分利用的数据库，为关于女退伍军人的稀少研究提供了新的信息，并成为未来针对性别的退伍军人健康研究的潜在模式。这项研究将进一步了解女退伍军人的保健需求，有助于确定所需的保健服务和指导保健政策，并将为针对这一日益增长的职业群体的研究议程提供基础。