Exercise in Patients with Advanced NSCLC: A Pilot Study

晚期非小细胞肺癌患者的运动：一项试点研究

• 批准号: 6840077
• 负责人: Jennifer Sue Temel
• 金额: $ 6.3万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-02 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6840077
• 关键词: aerobic exercise; clinical research; exercise; fatigue; functional ability; human subject; human therapy evaluation; nonsmall cell lung cancer; patient oriented research; quality of life

DESCRIPTION (provided by applicant): Fatigue is the most frequently reported symptom in advanced lung cancer patients with an estimated prevalence of approximately 80%. Studies have demonstrated that fatigue has a significant adverse impact on quality of life (QOL) of patients with advanced lung cancer as it negatively affects their functioning and mood. There is a growing body of literature supporting the use of exercise in the therapy of cancer-related fatigue. The primary goal of this pilot study is to assess the feasibility of a structured exercise-training program in patients with advanced non-small cell lung cancer (NSCLC), the most common form of lung cancer. Secondary goals include assessing the impact of an exercise program on symptom burden and functional capacity. Thirty patients with newly diagnosed advanced NSCLC will undergo a structured, yet individualized, eight-week exercise program consisting of aerobic conditioning and strength training under the supervision of a licensed physical therapist. The program's feasibility will be measured by the proportion of participants able to complete the entire exercise regimen. Fatigue and QOL will be assessed with the FACT-Fatigue Scale and FACT-Lung prior to and upon completion of the exercise program. Functional capacity will be assessed with the 6-minute walk test prior to and upon completion of the exercise program. If this study proves feasible, the data obtained from this pilot study will be used to design and implement a randomized controlled trial addressing the impact of exercise on clinical outcomes and QOL in advanced lung cancer patients.

描述（由申请人提供）： 疲劳是晚期肺癌患者中最常报告的症状，估计患病率约为80%。研究表明，疲劳对晚期肺癌患者的生活质量（QOL）有显著的不利影响，因为它会对他们的功能和情绪产生负面影响。有越来越多的文献支持使用运动治疗癌症相关的疲劳。这项试点研究的主要目标是评估结构化运动训练计划在晚期非小细胞肺癌（NSCLC）患者中的可行性，NSCLC是最常见的肺癌形式。次要目标包括评估运动计划对症状负担和功能能力的影响。30例新诊断的晚期NSCLC患者将在有执照的物理治疗师的监督下接受为期8周的结构化但个性化的运动计划，包括有氧训练和力量训练。该计划的可行性将通过参与者能够完成整个锻炼方案的比例来衡量。在运动计划之前和完成时，将使用FACT-Fatigue量表和FACT-Lung评估疲劳和QOL。在运动计划之前和完成后，将通过6分钟步行试验评估功能能力。如果这项研究证明是可行的，从这项初步研究中获得的数据将用于设计和实施一项随机对照试验，探讨运动对晚期肺癌患者临床结局和生活质量的影响。