Clinical Research Education in Genome Science (CREiGS)

基因组科学临床研究教育 (CREiGS)

• 批准号: 10359733
• 负责人: Emma Katherine Tara Benn
• 金额: $ 16.2万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10359733
• 关键词: Area; Biomedical Research; Cells; Clinical; Clinical Data; Clinical Research; Communities; Competence; Complex; Critical Thinking; Data; Data Analyses; Development; Educational Curriculum; Educational process of instructing; Ensure; Exercise; Faculty; Foundations; Future; Gene Expression; Genetic; Genomic medicine; Genomics; Goals; Health; Hour; Human; Hybrids; Institution; Knowledge; Logistics; Machine Learning; Medical; Methodology; Methods; Mission; National Human Genome Research Institute; Outcome; Participant; Patient Care; Patients; Persons; Phase; Phenotype; Play; Postdoctoral Fellow; Problem Solving; Proteomics; Provider; Recruitment Activity; Reproducibility; Research; Research Methodology; Research Personnel; Resources; Role; Single Nucleotide Polymorphism; Solid; Statistical Methods; Students; Technology; Tissues; Training; Translational Research; Treatment outcome; Underrepresented Minority; Underserved Population; Update; cancer therapy; clinical care; computerized tools; data integration; data management; disease phenotype; disorder subtype; doctoral student; education research; efficacy evaluation; genetic analysis; genome sciences; genomic data; grasp; health disparity; improved; individual patient; innovation; lectures; machine learning method; operation; personalized medicine; precision medicine; programs; recruit; response; statistical and machine learning; success; theories; therapy development; tool; transcriptomics; treatment optimization; virtual

Project Summary/Abstract The sensitivity and availability of omic technologies have enabled the genomic, transcriptomic and proteomic characterization of disease phenotypes, at the tissue and even the single cell level. This has allowed development of treatments that target specific disease subtypes, most notably in cancer treatment, and thus opened up opportunities for the development of precision/personalized medicine strategies for optimizing treatments for individual patients. Thus, new genomic science educational initiatives need to be continually updated to educate the clinical and translational workforce on how to effectively interpret and apply the findings from genomics studies. Patients of providers who have participated in these educational initiatives also benefit as it allows for more rapid integration of genomic study findings into the clinical care setting. Thus, in response to PAR-19-185, we propose to develop and implement the Clinical Research Education in Genome Science (CREiGS) program that will not only focus on the analysis of genomic data, but also on gene-expression data, the integration of these two data types, as well as introductory theory and application of statistical and machine learning methods. Specifically we propose to accomplish the following specific aims: 1. Develop and successfully implement the online and in-person phases of CREiGS to increase the methodologic ingenuity by which researchers tackle important genomics-related clinical problems. 2. Establish a Diversity Recruitment External Advisory Board to ensure that the most effective strategies are employed to recruit URM doctoral students, postdoctoral fellows, and faculty from academic institutions nationwide into CREiGS. 3. Enhance the dissemination phase of CREiGS by packaging and uploading the asynchronous lectures and the online critical thinking/problem solving assessments with solutions for publicly available, online teaching resources. 4. Implement effective methods to evaluate the efficacy of CREiGS by examining:1) the participants' grasp of the CREiGS core competencies, 2) the clarity and quality of the curriculum, 3) program logistics and operation, and 4) the participants' short-term and long-term success attributed to participation in CREiGS. In summary, we posit that CREiGS will provide participants with a solid foundation in genomics science to answer complex, clinical questions. We believe that CREiGS supports the mission of the NHGRI by providing researchers with rigorous training to “accelerate medical breakthroughs that improve human health.”

项目总结/摘要 组学技术的敏感性和可用性使基因组学、转录组学和基因组学成为可能。 以及疾病表型的蛋白质组学表征，在组织甚至单细胞水平上。这 允许开发针对特定疾病亚型的治疗方法，特别是癌症 治疗，从而为精确/个性化医疗的发展开辟了机会 为个体患者优化治疗的策略。因此，新的基因组科学教育计划 需要不断更新，以教育临床和翻译工作人员如何有效地 解释和应用基因组学研究的结果。参与这些活动的提供者的患者 教育计划也受益，因为它允许更快地将基因组研究结果整合到 临床护理设置。因此，为了响应PAR-19-185，我们建议开发和实施 基因组科学的临床研究教育（CREIGS）计划，将不仅专注于 分析基因组数据，也分析基因表达数据，这两种数据类型的整合，以及 作为统计和机器学习方法的入门理论和应用。另外还 建议实现以下具体目标： 1.开发并成功实施CREiGS的在线和面对面阶段，以增加 研究人员解决重要的基因组学相关临床问题的方法创新。 2.建立多元化招聘外部咨询委员会，以确保最有效的战略 聘请URM博士生，博士后研究员和学术机构的教师 全国范围内的CREIGS。 3.通过打包和上传异步讲座，加强CREiGS的传播阶段 以及在线批判性思维/问题解决评估， 教学资源 4.实施有效的方法来评估CREiGS的有效性，通过检查：1）参与者的掌握 CREIGS的核心竞争力，2）课程的清晰度和质量，3）计划物流和 4）参与者的短期和长期成功归因于参与CREiGS。 总之，我们认为CREiGS将为参与者提供基因组学科学的坚实基础， 回答复杂的临床问题我们相信，CREIGS支持NHGRI的使命，提供 研究人员接受严格的培训，以“加速改善人类健康的医学突破”。