Indiana Core Center for Clinical Research in Musculoskeletal Health
印第安纳州肌肉骨骼健康临床研究核心中心
基本信息
- 批准号:10707138
- 负责人:
- 金额:$ 77.02万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-09-19 至 2027-07-31
- 项目状态:未结题
- 来源:
- 关键词:AccountingAffectAgeAreaAutocrine CommunicationBig DataCOVID-19CaringChronic DiseaseClassificationClinical InvestigatorClinical ResearchClinical TrialsCommunitiesCommunity HealthComplexComputersDNADataData AnalysesData CollectionData MartDatabasesDiabetes MellitusDiagnosisDisciplineDiseaseDisparity populationDual-Energy X-Ray AbsorptiometryElectronic Health RecordEndocrineEnvironmental Risk FactorEthnic OriginExerciseFoodFosteringFractureFunctional disorderFundingGeneticGenomicsGoalsGovernmentGrowthHealthHealth Care VisitImageImpairmentIndianaIndividualInformaticsInjuryInternationalInterruptionJointsKidney DiseasesLinkLiver diseasesLongevityMalignant neoplasm of liverManuscriptsMeasuresMechanicsMetabolicMethodologyMinority GroupsMissionMorphologyMotivationMuscleMusculoskeletalMusculoskeletal DiseasesNeighborhood Health CenterObesityParticipantPatient EducationPatientsPatternPhenotypePhysical FunctionPopulationPopulation HeterogeneityPreventionProcess AssessmentPublishingQuality of lifeQuestionnairesRaceResearchResearch InfrastructureResearch PersonnelResearch Project GrantsResourcesSamplingScreening procedureSecureServicesSiteStandardizationSurveysTechniquesTestingTissuesTrainingUnited States National Institutes of HealthWalkingWorkaging populationbiobankboneclinical centercommunity engagementcostdata standardsdietarydisabilityethnic diversityexome sequencingfallsgenomic dataimprovedinnovationmembermultiple data sourcesnext generationnovelnutritionprogramsprospectiveracial diversityrecruitsarcopeniasexsocial determinantsstructural health determinantstissue resource
项目摘要
Advancements in the diagnosis and treatment of musculoskeletal disorders requires a robust
clinical research infrastructure and improved classification of the various disorders. The
overarching goal of the Indiana Core Center for Clinical Research (ICCCR) – the Indiana Center
for Musculoskeletal Health Clinical Research Center (ICMH-CRC) is to provide the needed
training and resources to enhance clinical research in musculoskeletal disorders to improve
musculoskeletal health across a broad range of diseases and populations. In Aim 1 we will deploy
the Administrative Core to facilitate cross disciplinary clinical research by connecting MSK
researchers with investigators studying chronic disease, enhance work with the community to
educate, inform, recruit and assess disadvantaged and minoritized populations, provide pilot
funding, and train the next generation of musculoskeletal researchers. We will innovate through
increased community engagement with racial and ethnically diverse populations to encourage
participation in MSK research. In Aim 2, we will integrate and harmonize big data from multiple
data sources in the Musculoskeletal Informatics Methodology (MIM) Core. We will develop a
facile, secure and innovative MSK Data Mart that integrates and harmonizes 1) The state-wide
“traditional” electronic health record (EHR), 2) Measures of social and structural determinants of
health based on geocoding, 3) The prospective collection of data from the FIT Core, and 4)
genomics and sample availability from the MSK Biobank. The Data Mart will expand our core
linkage and maximize MSK assessment based on the computable (computer data derived)
phenotypes developed and refined during our first P30. In Aim 3, we will foster growth of the
Musculoskeletal Function, Imaging, and Tissue (FIT) Resource Core to provide standardized
assessments of musculoskeletal health and expand the availability of biospecimens to facilitate
exploration of musculoskeletal health and disease. We will innovate our resource Core (FIT Core)
by taking the Core “on the road’ to the community health centers and organizations, diversifying
our tested population to develop race and ethnicity specific Z scores. We will also perform whole
exome sequencing on DNA collected from the participants to expand the utility of the MSK
functional (physical function), morphologic (imaging), and computable (electronic health record)
phenotypes by linking with genomic data. These goals will serve to promote and advance clinical
research in MSK disorders leading to prevention, diagnosis, treatment and cure for ALL
individuals.
肌肉骨骼疾病的诊断和治疗的进步需要一个强大的
临床研究基础设施和改善各种疾病的分类。的
印第安纳州临床研究核心中心(ICCCR)的总体目标-印第安纳州中心
肌肉骨骼健康临床研究中心(ICMH-CRC)是提供所需的
培训和资源,以加强肌肉骨骼疾病的临床研究,
肌肉骨骼健康在广泛的疾病和人群。在目标1中,我们将部署
行政核心,通过连接MSK促进跨学科临床研究
研究人员与研究慢性病的研究人员,加强与社区的合作,
教育、宣传、招募和评估弱势群体和少数群体,
资助,并培养下一代肌肉骨骼研究人员。我们将通过创新
增加社区与不同种族和族裔人口的接触,以鼓励
参与MSK研究。在目标2中,我们将整合和协调来自多个
数据来源于肌肉骨骼信息学方法(MIM)核心。我们将开发一个
方便,安全和创新的MSK数据集市,集成和协调1)全州范围内
“传统”电子健康记录(EHR),2)社会和结构决定因素的措施,
基于地理编码的健康,3)FIT核心数据的前瞻性收集,以及4)
基因组学和来自MSK生物库的样本可用性。数据集市将扩大我们的核心
联系和最大化MSK评估的基础上可计算的(计算机数据得出)
在我们第一个P30期间开发和完善的表型。在目标3中,我们将促进
肌肉骨骼功能、成像和组织(FIT)资源核心,
评估肌肉骨骼健康,并扩大生物标本的供应,
探索肌肉骨骼健康和疾病。我们将创新我们的资源核心(FIT核心)
通过将核心“在路上”带到社区卫生中心和组织,
我们的测试人群开发种族和民族特定的Z分数。我们还将全面执行
对从参与者收集的DNA进行外显子组测序,以扩大MSK的实用性
功能(身体功能)、形态(成像)和可计算(电子健康记录)
通过与基因组数据相关联的表型。这些目标将有助于促进和推进临床
MSK疾病的研究导致ALL的预防、诊断、治疗和治愈
个体
项目成果
期刊论文数量(13)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Prevalence of Nephrocalcinosis in Pseudohypoparathyroidism: Is Screening Necessary?
- DOI:10.1016/j.jpeds.2018.03.003
- 发表时间:2018-08-01
- 期刊:
- 影响因子:5.1
- 作者:Hansen, David W.;Nebesio, Todd D.;Imel, Erik A.
- 通讯作者:Imel, Erik A.
Mobility Impairment in Patients New to Dialysis.
- DOI:10.1159/000509225
- 发表时间:2020
- 期刊:
- 影响因子:4.2
- 作者:Moorthi RN;Fadel WF;Cranor A;Hindi J;Avin KG;Lane KA;Thadhani RI;Moe SM
- 通讯作者:Moe SM
Immediate and Delayed Effects of Joint Loading Activities on Knee and Hip Cartilage: A Systematic Review and Meta-analysis.
- DOI:10.1186/s40798-023-00602-7
- 发表时间:2023-07-14
- 期刊:
- 影响因子:4.6
- 作者:Coburn, Sally L. L.;Crossley, Kay M. M.;Kemp, Joanne L. L.;Warden, Stuart J. J.;West, Tom J. J.;Bruder, Andrea M. M.;Mentiplay, Benjamin F. F.;Culvenor, Adam G. G.
- 通讯作者:Culvenor, Adam G. G.
Bone Microarchitecture and Strength Adaptation to Physical Activity: A Within-Subject Controlled HRpQCT Study.
骨微结构和对身体活动的强度适应:受试者内控制的 HRpQCT 研究。
- DOI:10.1249/mss.0000000000002571
- 发表时间:2021
- 期刊:
- 影响因子:4.1
- 作者:Warden,StuartJ;Wright,ChristianS;Fuchs,RobynK
- 通讯作者:Fuchs,RobynK
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Sharon M Moe其他文献
You are what you eat—should it be all meat?: Impact of the carnivore diet on the risk of kidney stone development
人如其食——难道该全吃肉吗?:纯肉食饮食对肾结石发病风险的影响
- DOI:
10.1016/j.ajcnut.2024.11.024 - 发表时间:
2025-02-01 - 期刊:
- 影响因子:6.900
- 作者:
Hannah E Wilson;Sharon M Moe - 通讯作者:
Sharon M Moe
Sharon M Moe的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Sharon M Moe', 18)}}的其他基金
2023 Physiology, Biology and Pathology of Phosphate GRC
2023年磷酸盐GRC的生理学、生物学和病理学
- 批准号:
10608802 - 财政年份:2023
- 资助金额:
$ 77.02万 - 项目类别:
Indiana Clinical and Translational Sciences Institute
印第安纳临床与转化科学研究所
- 批准号:
10622172 - 财政年份:2023
- 资助金额:
$ 77.02万 - 项目类别:
Indiana University Kidney Training Program (IU-KTP)
印第安纳大学肾脏训练计划 (IU-KTP)
- 批准号:
10660956 - 财政年份:2019
- 资助金额:
$ 77.02万 - 项目类别:
Indiana University Kidney Training Program (IU-KTP)
印第安纳大学肾脏训练计划 (IU-KTP)
- 批准号:
9913535 - 财政年份:2019
- 资助金额:
$ 77.02万 - 项目类别:
Indiana University Kidney Training Program (IU-KTP)
印第安纳大学肾脏训练计划 (IU-KTP)
- 批准号:
10203951 - 财政年份:2019
- 资助金额:
$ 77.02万 - 项目类别:
Indiana University Kidney Training Program (IU-KTP)
印第安纳大学肾脏训练计划 (IU-KTP)
- 批准号:
10438786 - 财政年份:2019
- 资助金额:
$ 77.02万 - 项目类别:
Indiana Clinical and Translational Sciences Institute
印第安纳临床与转化科学研究所
- 批准号:
10401490 - 财政年份:2018
- 资助金额:
$ 77.02万 - 项目类别:
Indiana Clinical and Translational Sciences Institute
印第安纳临床与转化科学研究所
- 批准号:
10153909 - 财政年份:2018
- 资助金额:
$ 77.02万 - 项目类别:
Indiana Clinical and Translational Sciences Institute
印第安纳临床与转化科学研究所
- 批准号:
10000218 - 财政年份:2018
- 资助金额:
$ 77.02万 - 项目类别:
Indiana Core Center for Clinical Research in Musculoskeletal Health
印第安纳州肌肉骨骼健康临床研究核心中心
- 批准号:
10248402 - 财政年份:2017
- 资助金额:
$ 77.02万 - 项目类别:
相似海外基金
Hormone therapy, age of menopause, previous parity, and APOE genotype affect cognition in aging humans.
激素治疗、绝经年龄、既往产次和 APOE 基因型会影响老年人的认知。
- 批准号:
495182 - 财政年份:2023
- 资助金额:
$ 77.02万 - 项目类别:
Investigating how alternative splicing processes affect cartilage biology from development to old age
研究选择性剪接过程如何影响从发育到老年的软骨生物学
- 批准号:
2601817 - 财政年份:2021
- 资助金额:
$ 77.02万 - 项目类别:
Studentship
RAPID: Coronavirus Risk Communication: How Age and Communication Format Affect Risk Perception and Behaviors
RAPID:冠状病毒风险沟通:年龄和沟通方式如何影响风险认知和行为
- 批准号:
2029039 - 财政年份:2020
- 资助金额:
$ 77.02万 - 项目类别:
Standard Grant
Neighborhood and Parent Variables Affect Low-Income Preschool Age Child Physical Activity
社区和家长变量影响低收入学龄前儿童的身体活动
- 批准号:
9888417 - 财政年份:2019
- 资助金额:
$ 77.02万 - 项目类别:
The affect of Age related hearing loss for cognitive function
年龄相关性听力损失对认知功能的影响
- 批准号:
17K11318 - 财政年份:2017
- 资助金额:
$ 77.02万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Affect regulation and Beta Amyloid: Maturational Factors in Aging and Age-Related Pathology
影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
- 批准号:
9320090 - 财政年份:2017
- 资助金额:
$ 77.02万 - 项目类别:
Affect regulation and Beta Amyloid: Maturational Factors in Aging and Age-Related Pathology
影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
- 批准号:
10166936 - 财政年份:2017
- 资助金额:
$ 77.02万 - 项目类别:
Affect regulation and Beta Amyloid: Maturational Factors in Aging and Age-Related Pathology
影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
- 批准号:
9761593 - 财政年份:2017
- 资助金额:
$ 77.02万 - 项目类别:
How age dependent molecular changes in T follicular helper cells affect their function
滤泡辅助 T 细胞的年龄依赖性分子变化如何影响其功能
- 批准号:
BB/M50306X/1 - 财政年份:2014
- 资助金额:
$ 77.02万 - 项目类别:
Training Grant
Inflamm-aging: What do we know about the effect of inflammation on HIV treatment and disease as we age, and how does this affect our search for a Cure?
炎症衰老:随着年龄的增长,我们对炎症对艾滋病毒治疗和疾病的影响了解多少?这对我们寻找治愈方法有何影响?
- 批准号:
288272 - 财政年份:2013
- 资助金额:
$ 77.02万 - 项目类别:
Miscellaneous Programs