Indiana Core Center for Clinical Research in Musculoskeletal Health

印第安纳州肌肉骨骼健康临床研究核心中心

• 批准号: 10707138
• 负责人: Sharon M Moe
• 金额: $ 77.02万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-19 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10707138
• 关键词: Accounting; Affect; Age; Area; Autocrine Communication; Big Data; COVID-19; Caring; Chronic Disease; Classification; Clinical Investigator; Clinical Research; Clinical Trials; Communities; Community Health; Complex; Computers; DNA; Data; Data Analyses; Data Collection; Data Mart; Databases; Diabetes Mellitus; Diagnosis; Discipline; Disease; Disparity population; Dual-Energy X-Ray Absorptiometry; Electronic Health Record; Endocrine; Environmental Risk Factor; Ethnic Origin; Exercise; Food; Fostering; Fracture; Functional disorder; Funding; Genetic; Genomics; Goals; Government; Growth; Health; Health Care Visit; Image; Impairment; Indiana; Individual; Informatics; Injury; International; Interruption; Joints; Kidney Diseases; Link; Liver diseases; Longevity; Malignant neoplasm of liver; Manuscripts; Measures; Mechanics; Metabolic; Methodology; Minority Groups; Mission; Morphology; Motivation; Muscle; Musculoskeletal; Musculoskeletal Diseases; Neighborhood Health Center; Obesity; Participant; Patient Education; Patients; Pattern; Phenotype; Physical Function; Population; Population Heterogeneity; Prevention; Process Assessment; Publishing; Quality of life; Questionnaires; Race; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Sampling; Screening procedure; Secure; Services; Site; Standardization; Surveys; Techniques; Testing; Tissues; Training; United States National Institutes of Health; Walking; Work; aging population; biobank; bone; clinical center; community engagement; cost; data standards; dietary; disability; ethnic diversity; exome sequencing; falls; genomic data; improved; innovation; member; multiple data sources; next generation; novel; nutrition; programs; prospective; racial diversity; recruit; sarcopenia; sex; social determinants; structural health determinants; tissue resource

Advancements in the diagnosis and treatment of musculoskeletal disorders requires a robust clinical research infrastructure and improved classification of the various disorders. The overarching goal of the Indiana Core Center for Clinical Research (ICCCR) – the Indiana Center for Musculoskeletal Health Clinical Research Center (ICMH-CRC) is to provide the needed training and resources to enhance clinical research in musculoskeletal disorders to improve musculoskeletal health across a broad range of diseases and populations. In Aim 1 we will deploy the Administrative Core to facilitate cross disciplinary clinical research by connecting MSK researchers with investigators studying chronic disease, enhance work with the community to educate, inform, recruit and assess disadvantaged and minoritized populations, provide pilot funding, and train the next generation of musculoskeletal researchers. We will innovate through increased community engagement with racial and ethnically diverse populations to encourage participation in MSK research. In Aim 2, we will integrate and harmonize big data from multiple data sources in the Musculoskeletal Informatics Methodology (MIM) Core. We will develop a facile, secure and innovative MSK Data Mart that integrates and harmonizes 1) The state-wide “traditional” electronic health record (EHR), 2) Measures of social and structural determinants of health based on geocoding, 3) The prospective collection of data from the FIT Core, and 4) genomics and sample availability from the MSK Biobank. The Data Mart will expand our core linkage and maximize MSK assessment based on the computable (computer data derived) phenotypes developed and refined during our first P30. In Aim 3, we will foster growth of the Musculoskeletal Function, Imaging, and Tissue (FIT) Resource Core to provide standardized assessments of musculoskeletal health and expand the availability of biospecimens to facilitate exploration of musculoskeletal health and disease. We will innovate our resource Core (FIT Core) by taking the Core “on the road’ to the community health centers and organizations, diversifying our tested population to develop race and ethnicity specific Z scores. We will also perform whole exome sequencing on DNA collected from the participants to expand the utility of the MSK functional (physical function), morphologic (imaging), and computable (electronic health record) phenotypes by linking with genomic data. These goals will serve to promote and advance clinical research in MSK disorders leading to prevention, diagnosis, treatment and cure for ALL individuals.

诊断和治疗肌肉骨骼疾病的进步需要强大 临床研究基础设施和改善各种疾病的分类。这 印第安纳州临床研究中心（ICCCR）的总体目标 - 印第安纳州中心 对于肌肉骨骼健康临床研究中心（ICMH-CRC），将提供所需的 培训和资源以增强肌肉骨骼疾病的临床研究以改善 各种疾病和人群的肌肉骨骼健康。在AIM 1中，我们将部署 通过连接MSK来促进跨学科临床研究的行政核心 研究人员正在研究慢性病，增强与社区的工作 教育，告知，招募和评估灾难性的和少数的人口，向飞行员提供 资金，并培训下一代肌肉骨骼研究人员。我们将通过 增加社区参与种族和种族多样性的人群，以鼓励 参与MSK研究。在AIM 2中，我们将整合和协调来自多个的大数据 肌肉骨骼信息学方法（MIM）核心中的数据源。我们将发展一个 简化，安全和创新的MSK Data Mart，整合和协调1）全州范围内 “传统”电子健康记录（EHR），2）衡量社会和结构决定者的衡量标准 基于地理编码的健康，3）FIT核心的预期数据，4） 来自MSK生物库的基因组学和样本可用性。数据集市将扩大我们的核心 基于可计算的（计算机数据）的链接和最大MSK评估 表型在我们的第一个P30中开发和完善。在AIM 3中，我们将促进 肌肉骨骼功能，成像和组织（拟合）资源核心提供标准化 评估肌肉骨骼健康并扩大生物测量的可用性以促进 探索肌肉骨骼健康和疾病。我们将创新我们的资源核心（拟合核心） 通过将核心“在道路上”带到社区卫生中心和组织，使其多样化 我们测试的人群发展了种族和种族特定的Z分数。我们还将表演完整 从参与者收集的DNA上的外显子组测序以扩展MSK的效用 功能（身体功能），形态学（成像）和可计算（电子健康记录） 通过与基因组数据链接的表型。这些目标将有助于促进和推进临床 MSK疾病的研究导致所有人预防，诊断，治疗和治愈 个人。

项目成果

Prevalence of Nephrocalcinosis in Pseudohypoparathyroidism: Is Screening Necessary?

• DOI: 10.1016/j.jpeds.2018.03.003
• 发表时间: 2018-08-01
• 期刊: JOURNAL OF PEDIATRICS
• 影响因子: 5.1
• 作者: Hansen, David W.;Nebesio, Todd D.;Imel, Erik A.
• 通讯作者: Imel, Erik A.

Bone Microarchitecture and Strength Adaptation to Physical Activity: A Within-Subject Controlled HRpQCT Study.

骨微结构和对身体活动的强度适应：受试者内控制的 HRpQCT 研究。

• DOI: 10.1249/mss.0000000000002571
• 发表时间: 2021
• 期刊: Medicine and science in sports and exercise
• 影响因子: 4.1
• 作者: Warden,StuartJ;Wright,ChristianS;Fuchs,RobynK
• 通讯作者: Fuchs,RobynK

Mobility Impairment in Patients New to Dialysis.

• DOI: 10.1159/000509225
• 发表时间: 2020
• 期刊: American journal of nephrology
• 影响因子: 4.2
• 作者: Moorthi RN;Fadel WF;Cranor A;Hindi J;Avin KG;Lane KA;Thadhani RI;Moe SM
• 通讯作者: Moe SM

Immediate and Delayed Effects of Joint Loading Activities on Knee and Hip Cartilage: A Systematic Review and Meta-analysis.

• DOI: 10.1186/s40798-023-00602-7
• 发表时间: 2023-07-14
• 期刊: SPORTS MEDICINE-OPEN
• 影响因子: 4.6
• 作者: Coburn, Sally L. L.;Crossley, Kay M. M.;Kemp, Joanne L. L.;Warden, Stuart J. J.;West, Tom J. J.;Bruder, Andrea M. M.;Mentiplay, Benjamin F. F.;Culvenor, Adam G. G.
• 通讯作者: Culvenor, Adam G. G.