Training Program in Host Pathogen Interactions

描述(由申请人提供)：拟议的培训计划将为博士后学员提供严格的分子发病机制实验室经验，强调宿主与病原体的相互作用。培训将主要以实验室为基础，但也将包括由培训教师教授的宿主-寄生虫相互作用的必修学期课程。对于医学博士实习生(估计有一半)，在分配到实验室之前将进行实验室实习。最近的教师招聘努力已经导致在微生物发病机制的广泛领域形成了一大批成熟的研究人员，因此，本申请建议为博士后学员建立一个宿主-病原体相互作用的综合培训计划。除了他们共同的研究兴趣之外，这些教员中的许多人已经有了合作互动的证据。教师的研究兴趣包括毒力基因表达的调控、宿主与病原体的相互作用、分子免疫学和免疫防御、分子病毒学和生物信息学。该项目由12名教职员工组成，他们都持有NIH的补助金，作为一个整体，他们都有丰富的培训历史。作为一个整体，这一群体在各自的领域获得了国内和国际的认可。培训教师代表了广泛的系属关系，包括波士顿大学医学院的医学系和微生物学系，以及波士顿大学的生物医学工程部。该计划的主要目标是：1)招募和招收包括未被充分代表的少数族裔在内的最高素质的受训人员；2)为这些受训人员提供多学科的分子发病学背景，并在一个重点研究宿主与寄生虫相互作用的项目中进行密集的实验室培训(S)；3)教会受训人员批判性思考和提出相关和可行的研究问题；4)向这些受训人员灌输道德行为意识；5)帮助培养受训人员之间有效的书面和口头沟通技能；以及6)促进宿主与病原体相互作用培训计划的学生和教职员工之间的合作互动。

DESCRIPTION (provided by applicant): The proposed training program will provide postdoctoral trainees with a rigorous laboratory experience in molecular pathogenesis, emphasizing host-pathogen interactions. Training will be primarily laboratory based, but will also include a required semester course in host-parasite interactions taught by the training faculty. For MD trainees (estimated to be half) a laboratory practicum will precede their assignment to laboratories. Recent faculty recruitment efforts have resulted in the formation of a critical mass of established investigators in the broad area of microbial pathogenesis and accordingly this application proposes to establish an integrated training program for post doctoral trainees in host-pathogen interactions. In addition to their common research interests, many of these faculty already have evidence of collaborative interactions. Faculty research interests encompass areas that include regulation of virulence gene expression, host- pathogen interactions, molecular immunology and immune defense, molecular virology and bioinformatics. The program consists of 12 faculty, all of whom hold NIH grants and who, as a group, have had a substantial training history. As a whole, this group has earned national and international recognition in their respective fields. The training faculty represents a broad range of departmental affiliations, including the Departments of Medicine and Microbiology at Boston University School of Medicine, and the Division of Biomedical Engineering at Boston University. The major goal of the program will be to: 1) recruit and enroll trainees of the highest quality including underrepresented minorities; 2) provide these trainees with a multidisciplinary background in molecular pathogenesis coupled with intensive laboratory training in a focused project that examines a host-parasite interaction(s); 3) to teach trainees to think critically and to ask relevant and feasible research questions; 4) to instill these trainees with a sense of ethical behavior; 5) to help develop effective written and oral communication skills among the trainees; and 6) to facilitate collaborative interactions among both students and faculty of the host-pathogen interaction training Program.