Family Psychopathology in Child Bipolarity

儿童双相情感障碍的家庭精神病理学

• 批准号: 6788089
• 负责人: BARBARA GELLER
• 金额: $ 25.06万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-02-01 至 2005-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6788089
• 关键词: adolescence (12-20); attention deficit disorder; behavioral /social science research tag; bipolar depression; child mental disorders; clinical research; data collection methodology /evaluation; family structure /dynamics; human subject; interview; mental health epidemiology; middle childhood (6-11); psychopathology; statistics /biometry

DESCRIPTION (provided by applicant): This application is to complete data collection and to conduct statistical analyses for the ongoing study "Family Psychopathology in Child Bipolarity". The aim of this project is to perform direct interviews of the first degree relatives of three groups of probands (total N=263) who are participants in the ongoing parallel study "Phenomenology and Course of Pediatric Bipolar Disorder". Proband groups are: (1) 89 probands with a prepubertal and early adolescent bipolar disorder phenotype (PEA-BP). (2) 80 probands with attention-deficit hyperactivity disorder (ADHD) (hyperactive or combined types). (3) 94 probands who are normal community controls (CC). Merikangas et al (1989) criteria were used to design this family study, including that there were blind raters (no knowledge of the proband's group), rigorous assessment of the probands, longitudinal validation of the phenotype, no exclusions for psychopathology in the first degree relatives and control for specificity (ADHD control group). Ongoing data analysis supports the main study hypotheses. Specifically, there is significantly higher familial aggregation of bipolar disorders among the relatives of the PEA-BP compared to the ADHD and CC groups. Also, there is far greater familial aggregation of bipolar disorders among the relatives of the PEA-BP group compared to relatives of adult bipolar probands reported in the literature. Rates of mood disorders among the relatives of the CC group are similar to those reported in epidemiological samples, which provides reliability of the study methods. Validation of PEA-BP has been shown by reliable assessment, six-month stability, and one and two year diagnostic outcome. Support of the family study hypotheses will provide additional, important validation of the existence of prepubertal and early adolescent mania. Establishing high familial aggregation of bipolar disorders in relatives of PEA-BP probands will provide the basis for future genetic and genetic-environment interaction studies.

描述（由申请人提供）：此申请是为了完成数据收集并进行统计分析，以进行正在进行的研究“儿童双极性家庭心理病理学”。该项目的目的是对正在进行的平行研究“现象学和小儿双相情感障碍的过程”的参与者进行三组概率（总n = 263）的一级亲戚的直接访谈。概率组为：（1）具有青春期前和早期青少年躁郁症表型（PEA-BP）的89个概率。 （2）80个具有注意力缺陷多动障碍（ADHD）（多动或组合类型）的概率。 （3）94个是正常社区控制（CC）的概率。 Merikangas等人（1989年）用于设计这项家庭研究，包括有盲人评估者（对概率组不了解），对证据的严格评估，对表型的纵向验证，在第一级亲戚中对精神病理学的纵向验证和对特异性的控制性相关性（ADHD对照组）。正在进行的数据分析支持主要研究假设。具体而言，与ADHD和CC组相比，PEA-BP亲戚之间的双极疾病的家族性疾病的家族性疾病的家族性疾病的家族性疾病明显更高。同样，与文献中报道的成年双极探针的亲属相比，豌豆BP组亲属之间的双相疾病的家族性疾病的家族性疾病的家族性疾病更大。 CC组亲属之间的情绪障碍率与流行病学样本中报道的相似，该样本提供了研究方法的可靠性。 PEA-BP的验证已通过可靠的评估，六个月的稳定性以及一年和两年的诊断结果表明。家庭研究假设的支持将为青春期前和早期青少年躁狂症的存在提供其他重要的验证。在PEA-BP概率的亲属中建立高度家族性聚集，将为将来的遗传和遗传环境相互作用研究提供基础。

项目成果

Maternal iron deficiency and the risk of schizophrenia in offspring.

• DOI: 10.1001/archpsyc.65.10.1136
• 发表时间: 2008-10
• 期刊: ARCHIVES OF GENERAL PSYCHIATRY
• 作者: Insel, Beverly J.;Schaefer, Catherine A.;McKeague, Ian W.;Susser, Ezra S.;Brown, Alan S.
• 通讯作者: Brown, Alan S.