FAMILY PSYCHOPATHOLOGY IN CHILD BIPOLARITY

儿童双向情感障碍的家庭心理病理学

• 批准号: 6742124
• 负责人: BARBARA GELLER
• 金额: $ 6.31万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-02-01 至 2004-08-06
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6742124
• 关键词: adolescence (12-20); adult human (21+); attention deficit disorder; behavioral /social science research tag; bipolar depression; child mental disorders; clinical research; diagnosis design /evaluation; disease /disorder etiology; family structure /dynamics; human subject; mental disorder diagnosis; mental health epidemiology; middle childhood (6-11); pediatrics

Given mounting evidence for prepubertal-specific manifestations of DSM- IV mania, establishing continuities/discontinuities of bipolarity (BP) across the lifespan is crucial. Because family studies are paramount among validating methodologies, the paucity of family study data from prepubertal BP probands is striking. An especially compelling opportunity to fill this gap in family study knowledge exists in our research unit because of ongoing phenomenologic, naturalistic course, and molecular genetic investigations. These ongoing studies are conducted on a population of 270 non-adopted probands aged 7-16 years old at baseline entry into the phenomenology project. These 270 subjects comprise 90 with BP (with or without ADHD), 90 with ADHD (without BP or other major mood disorders), and 90 community controls (without BP, other major mood disorders or ADHD) who were ascertained to optimize future family genetic studies. Thus, the family study proposed in this application will use an already established pediatric aged proband population and will include probands' first degree relatives, who already participate in molecular genetic investigations. In the proposed work, first degree relatives (mothers, fathers and siblings aged seven or older) will be directly assessed by blind raters to establish DSM-IV diagnoses. Data on deceased or otherwise unavailable relatives will be obtained by family history from two informants, to increase caseness. Incorporation of the proposed family study with ongoing interrelated and interlocking phenomenology, naturalistic course, and molecular-genetic investigations will provide crucial data on differentiating prepubertal BP from ADHD and on establishing continuities/discontinuities between prepubertal versus adult onset mania. This application is a second revision to NIMH R01 MH57451.

给出了越来越多的DSM-前特异性表现的证据 IV躁狂症，建立双极性的连续性/不连续性（BP） 整个寿命至关重要。 因为家庭研究是最重要的 在验证方法中，家庭研究数据的匮乏 青春期前BP概率令人震惊。 一个特别引人注目的 在我们的家庭学习知识中填补这一空白的机会存在于我们的 研究部门由于持续的现象学，自然主义课程， 和分子遗传研究。 这些正在进行的研究是 以7-16岁的270个非预先概率的人口进行 基线进入现象学项目时的老式。 这270 受试者由BP组成90（有或没有多动症），为90，ADHD为90 （没有BP或其他主要情绪障碍）和90个社区控制 （没有BP，其他主要情绪障碍或多动症）被确定 优化未来的家庭遗传研究。因此，家庭研究 在本申请中提出的建议将使用已经建立的儿科 老化的概率和人口，将包括Probands的一级学位 亲戚，他们已经参与了分子遗传研究。 在拟议的工作中，一级亲戚（母亲，父亲和父亲 七岁或七岁以上的兄弟姐妹将直接评估盲人 建立DSM-IV诊断。 有关死者或其他的数据 家族史将从两个 线人，增加舱口。 将拟议的家庭研究纳入持续的相互关联和 互锁现象学，自然主义课程和分子遗传学 调查将提供有关区分青春期的关键数据 来自多动症的BP以及建立连续性/不连续性 青春期前与成人发作躁狂症。 这个应用程序是第二个 修订到NIMH R01 MH57451。