EVOLUTIONARY GENETICS OF MALE REPRODUCTIVE TRAITS IN MUS

MUS 雄性生殖特征的进化遗传学

• 批准号: 6739141
• 负责人: MATTHEW D DEAN
• 金额: $ 4.11万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-05-17 至 2007-05-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6739141
• 关键词: Mus musculus; evolution; fertility; gene expression; genetic library; genetic polymorphism; genetics; genotype; male; natural selections; phenotype; postdoctoral investigator; reproduction; species difference; sperm

DESCRIPTION (provided by applicant): A major goal in evolutionary genetics is to connect genotypic and phenotypic variation both within and between species to better understand the functional consequences of molecular variation, and ultimately the genetic basis of traits that affect fitness. Several male reproductive traits in mammals are likely to play a key role in fitness. Recent work in a variety of species has shown that genes involved in male reproduction are often targets of natural selection. The three main objectives of this study are to: 1) Test the hypothesis that genes involved in male reproduction in house mice are subject to positive natural selection, both within and between species. Rates of divergence in candidate loci will be investigated among four closely related Mus lineages and Rattus rattus. Polymorphism will be investigated in a sample of 20 wild-derived M. domesticus sampled from its native range; 2) Document naturally occurring phenotypic variation in sperm competitive ability using these same 20 M. domesticus males. Males will compete against a common male genotype for fertilizations; 3) Connect phenotypic variation in sperm competitive ability to genotypic variation observed in candidate loci. These studies will help uncover the genetic basis of male reproductive fitness in a natural population of house mice.

描述（由申请人提供）：进化遗传学的一个主要目标是将物种内和物种间的基因型和表型变异联系起来，以更好地理解分子变异的功能后果，并最终理解影响适应性的性状的遗传基础。哺乳动物的几个雄性生殖特征可能在适应性中起关键作用。最近对各种物种的研究表明，与雄性生殖有关的基因往往是自然选择的目标。本研究的三个主要目的是：1）测试的假设，涉及在家鼠雄性生殖的基因受到积极的自然选择，无论是在物种内和物种之间。将在四个密切相关的小鼠谱系和大鼠之间研究候选基因座的分歧率。将在20个野生来源的M的样品中研究多态性。从其原生范围内取样的Escherichoticus; 2）使用这些相同的20 M记录精子竞争能力中自然发生的表型变异。雄性蜘蛛雄性将与共同的雄性基因型竞争受精; 3）将精子竞争能力的表型变异与候选基因座中观察到的基因型变异相关联。这些研究将有助于揭示家鼠自然种群中雄性生殖适应性的遗传基础。