Escape from BRAF-induced human melanocyte senescence in the genesis of melanoma

在黑色素瘤的发生过程中逃避 BRAF 诱导的人类黑色素细胞衰老

• 批准号: nhmrc : 512318
• 负责人: Prof Helen Rizos
• 金额: $ 40.13万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/escape-braf-induced-genesis-melanoma/99070
• 关键词: Escape; BRAF; induced; human; melanocyte

Melanoma is the most lethal form of skin cancer and activation of the MAPK growth pathway is a crucial step in the initiation of this cancer, but alone is insufficient, as most melanocytes with active MAPK exist in a growth arrested state. The mechanisms responsible for arresting melanocytes in the presence of active MAPK will be investigated. This project will discover why some melanocytes develop into melanomas whereas most do not.

黑色素瘤是最致命的皮肤癌，MAPK 生长途径的激活是这种癌症发生的关键步骤，但仅激活 MAPK 生长途径还不够，因为大多数具有活跃 MAPK 的黑素细胞都处于生长停滞状态。将研究在活性 MAPK 存在的情况下阻止黑素细胞的机制。该项目将发现为什么一些黑色素细胞会发展成黑色素瘤，而大多数则不会。